- A new study investigated a potential role of bacteria and fungi in head and neck cancers.
- In particular, the scientists focused on the actions of metabolites that these microorganisms produce.
- The researchers showed that biofilms formed by fungi and bacteria can activate genes associated with these cancer types.
Globally, there were approximately 890,000 new cases of HNSCC and 450,000 associated deaths in 2018.
Researchers at São Paulo State University (UNESP) in Araraquara, Brazil, hope that learning more about
The researchers conducted a laboratory study that showed how fungi and bacteria can activate genes associated with head and neck tumors. The study appears in Frontiers in Cellular and Infection Microbiology.
The researchers’ work suggests that the metabolism of biofilms stimulates tumor cells by favoring cell signaling pathways that are required for tumor development. Biofilms occur when bacteria congregate and form a community.
Specifically, the study details how biofilms secrete metabolites, which are the intermediate or end product of metabolism. These metabolites can modify the expression of genes that experts associate with tumor cell growth.
“It was very exciting for us that we found a relationship between the metabolites of these microbes [and cell behavior],” Dr. Paula Aboud Barbugli, a professor at UNESP’s Araraquara Dental School and co-leader of the study, told Medical News Today.
The researchers introduced metabolites from biofilms to healthy oral epithelial cells and HNSCC cells. Specifically, they used metabolites produced by Candida albicans (C. albicans), a
The scientists stimulated both healthy and neoplastic cells for either 4 or 24 hours with single and dual biofilms of C. albicans and S. aureus.
They found that the biofilms promoted changes in cell gene expression in both normal and neoplastic oral epithelial cell lines. “They are exerting some effect on cellular behavior,” Dr. Barbugli explained to MNT.
Another key finding of the study is that molecules secreted by these microorganisms in biofilms may modify host cell activities far away from the primary infection site. “Our patients who wear [dentures], they have lots of C. albicans,” Dr. Barbugli said. “It may influence some cancers of the esophagus or [cancer in some other location of the body].”
The microorganisms used by the researchers were not selected at random. Authors of a 2005 study foundC. albicans isolated in 66.7% of studied dentures, and S. aureus — in 49.5%.
“Control of biofilms, including denture and oral cavity hygiene, is extremely important to minimize inflammatory processes, as shown by our prior research and the study just published, which points to interference with the expression of genes associated with tumor progression,” said Dr. Carlos Eduardo Vergani, a professor at UNESP’s Araraquara Dental School and principal investigator of the research.
Dr. Barbugli told MNT that she would like to see more dentists and doctors work together to study the oral microbiome, which consists of more than
Next, the UNESP researchers plan to study the prevalence of C. albicans and S. aureus biofilms in the dentures and oral cavities of people with HNSCC in Brazil to get an idea about whether those biofilms influence a person’s prognosis.
Dr. Barbugli is particularly interested in studying patients with HPV-negative HNSCC, which generally has a