Ajovy (fremanezumab-vfrm) is a brand-name solution for subcutaneous injection. It’s prescribed for the prevention of migraine episodes in adults. As with other drugs, Ajovy can cause side effects, such as injection site reactions.

Read on to learn about potential common, mild, and serious side effects. For a general overview of Ajovy, see this article.

Ajovy can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few hours to days. But if they last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

The most common side effects reported by people who took Ajovy in clinical trials were injection site reactions. For more information, see the “Side effect specifics” section below.

Mild side effects can occur with Ajovy use. This section may not include all possible mild side effects of the drug. For more information, you can refer to Ajovy’s prescribing information.

Mild side effects that have been reported with Ajovy include reactions at the injection site. For more information, see the “Side effect specifics” section below.

These side effects are usually temporary, lasting a few hours to days. But if they last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect while using Ajovy and want to tell the FDA about it, visit MedWatch.

It’s rare for Ajovy to cause serious side effects. The main serious side effect reported with Ajovy was severe allergic reaction. For more information, see the “Side effect specifics” section below.

To learn more about the possible side effects of Ajovy, you can refer to the drug’s prescribing information.

If you develop serious side effects while using Ajovy, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Here are some frequently asked questions about Ajovy’s side effects and their answers.

Are there reviews from people who had side effects from Ajovy?

It’s possible to find online reviews and testimonials from people who have used Ajovy. However, it’s important to keep in mind that these may not be reliable sources of information about the drug. Each person using Ajovy may have a different experience with the medication due to their individual health history.

Many factors may influence the way your body responds to Ajovy. These include other conditions you might have and other medications you might take. So your experience with Ajovy may be different from that of other people.

The manufacturer of Ajovy has stories from people who have used this medication to help prevent migraine episodes. But the best source of information about the medication is your doctor. They can give you more details about how the drug affected people in clinical trials. And based on your health history, your doctor can help you decide whether Ajovy is a good option for you.

Is hair loss a side effect of Ajovy?

Hair loss is not known to be a side effect of Ajovy. Hair loss wasn’t reported in clinical trials of the drug.

Hair loss has been reported with certain other medications used to help prevent migraine episodes, such as Depakote (divalproex) and Topamax (topiramate). Your doctor might prescribe Ajovy with other preventive drugs such as these.

If you’re concerned about hair loss, talk with your doctor. They may be able to suggest ways to help prevent or treat it.

If I stop using Ajovy, could I develop withdrawal symptoms?

It’s not likely. Withdrawal symptoms are side effects that you may have if you stop taking a drug that your body is dependent on. (With dependence, your body needs the drug to feel like it usually does.) Ajovy doesn’t cause dependence, and withdrawal symptoms haven’t been reported in people who stop using this medication.

However, if you have fewer and less severe migraine episodes with Ajovy, stopping treatment could cause them to return or worsen.

If you’re concerned about stopping Ajovy treatment, talk with your doctor. They can advise you on whether ending your treatment is a good option. If you do stop using the medication, your doctor may recommend switching to a different drug to help prevent migraine episodes.

Does Ajovy cause depression?

No, depression is not a known side effect of Ajovy. Depression wasn’t reported in clinical trials of the medication.

It’s important to note that depression has been reported with certain other drugs used to help prevent migraine episodes, such as divalproex and topiramate. Your doctor might prescribe Ajovy with other preventive medications such as these.

Keep in mind that people who have migraine may have a slightly increased risk of developing mental health conditions, such as depression or anxiety. Also, migraine is more common in people with depression than those without depression.

If you have symptoms of new or worsening depression or other unusual changes in your mood or behavior, talk with your doctor. They can investigate possible causes and recommend suitable treatments.

Should I expect joint pain during Ajovy treatment?

Joint pain is not a known side effect of Ajovy. It wasn’t reported in clinical trials of this medication.

Joint pain has been reported with other drugs used to help prevent migraine episodes, including divalproex and topiramate. Your doctor might prescribe Ajovy with other preventive medications such as these.

If you have joint pain, talk with your doctor. They can look into possible causes and recommend treatments that may help.

Learn more about some of the side effects that Ajovy may cause.

Reactions at the injection site

You will receive Ajovy as a subcutaneous injection, and it’s possible to have skin reactions around the area where the shot is given. These are known as injection site reactions. In clinical trials, injection site reactions were the most common side effects reported with Ajovy.

Injection site reactions may include:

  • pain or tenderness
  • hardening of the skin
  • redness or other temporary changes in skin color
  • itching
  • rash

Injection site reactions are usually mild and temporary. They tend to ease in a few hours to days.

What you can do

To help prevent injection site reactions, you can try using a different site each time you inject Ajovy. Sites you can use for your injection are:

  • your abdomen (at least 2 inches from your belly button)
  • front of your thighs (at least 2 inches above your knee and at least 2 inches below your groin)
  • back of your upper arms (if you have a caregiver who gives you injections)

Your doctor may recommend that you receive Ajovy as one injection once every month. Or they may have you receive it as three injections at the same time once every 3 months. If you need three injections for your dose, you can use the same injection site, such as your abdomen. However, you should use a slightly different spot for each injection.

To help prevent injection site reactions, it’s also important to carefully follow the instructions for using Ajovy. Here are some key points:

  • Before giving yourself an injection, allow Ajovy to reach room temperature after you take it out of the refrigerator. You should not warm up the medication by heating it, such as with hot water or a microwave.
  • You should avoid injecting Ajovy into areas of skin that are tender, discolored, bruised, or hard. And you should not inject the medication into areas that have tattoos, scars, or stretch marks.
  • If you inject other medications, choose different spots for injection than where you inject Ajovy.
  • After injecting Ajovy, press gently on the injection site with a clean cotton ball or gauze pad for a few seconds.
  • Try not to rub the injection site.

If you have an injection site reaction that bothers you, it may help to apply an ice pack to the affected area. If the reaction is severe or lasts longer than a few days, be sure to talk with your doctor or pharmacist. They can recommend possible treatments for injection site reactions.

Allergic reaction

As with most drugs, Ajovy can cause an allergic reaction in some people. But these reactions aren’t common. When they do occur, they’re typically mild or moderate. Serious allergic reactions are rare.

Allergic reactions can occur within hours after receiving Ajovy. They can also happen up to a month after having an injection.

Symptoms of mild or serious allergic reactions can include:

  • skin rash
  • itching
  • flushing
  • swelling under your skin, typically in your lips, eyelids, feet, or hands
  • swelling of your mouth, tongue, or throat, which can make it hard to breathe

What you can do

For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should keep using Ajovy.

But if your symptoms are serious and you think you’re having a medical emergency, immediately call 911 or your local emergency number. You may need treatment with medications such as corticosteroids. If you have a serious allergic reaction, your doctor will likely recommend that you stop using Ajovy.

Be sure to talk with your doctor about your health history before you use Ajovy. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. The conditions and factors to consider include:

Allergic reaction: If you’ve had an allergic reaction to Ajovy or any of its ingredients, your doctor will likely not prescribe Ajovy. Ask your doctor about other medications that may be better options for you.

Alcohol use with Ajovy

Alcohol is not known to affect Ajovy. However, alcohol can be a trigger for migraine episodes in some people.

If you’re not sure what triggers your migraine episodes, it’s useful to keep a migraine diary. It can help you determine whether your episodes are linked to certain drinks, foods, or situations. (For tips on keeping a migraine diary, see this article.)

If you notice that alcohol triggers your migraine episodes or makes them worse, it may help to avoid drinking alcohol. You can talk with your doctor to learn more.

Pregnancy and breastfeeding while using Ajovy

It is unknown whether Ajovy is safe to use during pregnancy or breastfeeding.

Pregnancy. Ajovy hasn’t been studied in pregnant people. In animal studies, no negative effects were seen when Ajovy was given to pregnant animals. But keep in mind that studies in animals don’t always predict what will happen in humans. If you’re pregnant or plan to become pregnant, talk with your doctor about the possible risks and benefits of using Ajovy.

If you decide to use Ajovy during pregnancy, consider enrolling in the drug’s pregnancy registry. This registry collects information about the safety of Ajovy when used during pregnancy. For more information, visit the registry’s website or call 833-927-2605.

Breastfeeding: It is unknown whether Ajovy passes into breast milk or whether it can affect a child who is breastfed. If you’re breastfeeding or plan to breastfeed, talk with your doctor about the pros and cons of Ajovy treatment.

Ajovy causes very few side effects. Most side effects are mild and temporary and generally don’t require medical attention.

Some serious side effects are also possible, although these are rare. Talk with your doctor right away if you experience symptoms of an allergic reaction with Ajovy. This could be serious and may need emergency medical treatment.

If you’d like to learn more about Ajovy, talk with your doctor or pharmacist. They can help answer any questions you have about side effects from using the drug.

Besides talking with your doctor or pharmacist, you can do some research on your own. These articles might help:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.