Augtyro (repotrectinib) is a brand-name drug prescribed for a specific kind of lung cancer. Augtyro comes as an oral capsule that’s typically taken once or twice per day. The dosage can vary based on certain factors.

Augtyro is approved by the Food and Drug Administration (FDA) to treat non-small cell lung cancer (NSCLC) in adults. Doctors may prescribe the drug specifically for NSCLC that has both:

Augtyro belongs to a drug class called kinase inhibitors. It’s not available in a generic version.

Keep reading for specific information about the dosage of Augtyro, including its strength and how to take the medication. For a comprehensive look at Augtyro, see this article.

Note: This article describes the typical dosage for Augtyro provided by the drug’s manufacturer. When taking Augtyro, always follow the dosage prescribed by your doctor.

Below is information about Augtyro’s form, strength, and dosage.

Augtyro form

Augtyro comes as an oral capsule.

Augtyro strength

Augtyro comes in one strength of 40 milligrams (mg).

Typical dosages

Typically, your doctor will prescribe a low dosage to start. Then they’ll adjust it over time to reach the amount that’s right for you.

The following information describes dosages that are commonly prescribed or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those shown below.

Dosage for ROS1-positive NSCLC

Doctors may prescribe Augtyro to treat certain cases of ROS1-positive NSCLC. The recommended starting dose is 160 mg taken once daily. After 14 days, your doctor will usually increase your dosage to 160 mg twice daily. This is the typically recommended dosage for your condition.

Your doctor may pause or stop Augtyro if you develop certain side effects from the drug. If they restart Augtyro, they may lower your dose.

For more information about your specific dosage, talk with your doctor.

How to take Augtyro

Augtyro comes as a capsule that you swallow whole. Do not open, dissolve, break, crush, or chew the capsule. Also, discard any damaged or cracked capsules.

You’ll take your dose with water, with or without food. However, your doctor may advise you to avoid grapefruit and grapefruit juice during Augtyro treatment. This is because the drug may interact with grapefruit.

It’s best to take Augtyro around the same time each day. This helps keep a steady level of the drug in your body so it can work effectively. If you miss a dose, skip it and take your next dose at your usual time. Follow this same guidance if you vomit your dose. Do not take another dose to make up for a missed or lost dose.

Be sure to store Augtyro at room temperature, away from children.

If you have trouble swallowing capsules, see this article for tips, or consult your doctor or pharmacist. For questions on how to take Augtyro, talk with your doctor or pharmacist. You can also refer to the Augtyro patient information.

Note: Tell your doctor right away about any side effects you experience while taking Augtyro. (For details about these, see the “Side effects” section of this article.) In addition, your doctor may advise you not to drive or use machinery until you know how Augtyro affects you.

Long-term treatment

Augtyro is meant to be a long-term treatment. However, certain factors may limit the length of treatment. Your doctor may stop Augtyro if your cancer worsens or certain side effects occur. If you and your doctor determine that Augtyro is safe and effective for you, you may take it long term.

Before you start taking Augtyro, your doctor will discuss your treatment plan with you. Talk with your doctor if you have questions about how long you can expect to take Augtyro.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Augtyro in an easy-open container. They also may recommend tools that can make it easier to open bottles.

It’s important that you do not take more Augtyro than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects, harmful effects, or overdose.

If you take more than the recommended amount of Augtyro

Call your doctor right away if you believe you’ve taken too much Augtyro. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.