Auvi-Q is a brand-name injection that’s prescribed for severe allergic reactions. Auvi-Q contains the active drug epinephrine, which is also called adrenaline.

Auvi-Q is FDA-approved for the emergency treatment of severe allergic reactions, such as anaphylaxis, in adults and children.

If you’re at risk of severe allergic reactions, your doctor may prescribe Auvi-Q to keep with you at all times.

Drug details

Auvi-Q comes as an autoinjector containing a single dose of the medication. The autoinjector is used to administer the medication by injection into the thigh. You can self-administer Auvi-Q, or someone else can do it for you.

Auvi-Q comes in three strengths:

  • 0.1 milligrams epinephrine in 0.1 milliliters liquid solution (0.1 mg/0.1 mL)
  • 0.15 mg/0.15 mL
  • 0.3 mg/0.3 mL

Effectiveness

For information about the effectiveness of Auvi-Q, see the “Auvi-Q uses” section below.

Auvi-Q is a brand-name drug that contains the active drug epinephrine. This active drug is also available as a generic medication. A generic drug is an exact copy of the active drug in a brand-name medication.

The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.

If you’re interested in using the generic form of Auvi-Q, talk with your doctor. They can tell you if it comes in forms and strengths that can be used for your condition.

Here are answers to some frequently asked questions about Auvi-Q.

How does Auvi-Q compare to EpiPen? What’s the cost of Auvi-Q vs. EpiPen?

Auvi-Q and EpiPen are very similar medications. They’re both used to treat severe allergic reactions. They both contain a single dose of the active drug epinephrine. And both come as an autoinjector that’s used to give the medication by injection into the thigh. These drugs can also cause the same side effects.

There are some differences between these medications:

  • Size and shape. Auvi-Q is a rectangular device about the size of a credit card and the thickness of a cell phone. This device gives electronic voice instructions to guide you through the injection process, even if you’ve not had training. EpiPen is a pen device. It doesn’t give voice instructions.
  • Strength. EpiPen comes in two forms, EpiPen and EpiPen Jr (junior), which contain different strengths of epinephrine. The junior form is suitable for children weighing at least 15 kilograms (kg)*, which is about 33 pounds (lb). Auvi-Q comes in the same strengths as EpiPen and EpiPen Jr. However, it’s also available in a lower strength that’s suitable for infants and toddlers weighing at least 7.5 kg (about 16.5 lb).

The cost of Auvi-Q and EpiPen depends on your insurance plan, as well as your location, and the pharmacy you use. To find out more about how the cost of Auvi-Q compares with EpiPen, talk with your insurance company or pharmacist.

* One kg equals about 2.2 lb.

How much does Auvi-Q cost with insurance?

The cost of Auvi-Q with insurance depends on your insurance plan, your location, and the pharmacy you use.

To find out more about the cost of Auvi-Q, talk with your insurance company or pharmacist.

Do I need to get emergency medical help after using Auvi-Q, even if I feel better?

Yes, you should still get emergency medical help after using Auvi-Q, even if you feel better. Symptoms of the allergic reaction could return, and you may need further treatment for the allergic reaction.

If you have additional questions about using Auvi-Q, talk with your doctor or pharmacist.

As with all medications, the cost of Auvi-Q can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Before approving coverage for Auvi-Q, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered.

If you’re not sure whether you’ll need to get prior authorization for Auvi-Q, contact your insurance company.

Financial and insurance assistance

If you need financial support to pay for Auvi-Q or help understanding your insurance coverage, help is available.

A savings program and a patient assistance program are available for Auvi-Q. For more information and to find out if you’re eligible for support, call 877-30-AUVIQ (877-302-8847) or visit the drug manufacturer’s website.

To learn more about saving money on prescriptions, check out this article.

Mail-order pharmacies

Auvi-Q may be available through a mail-order pharmacy. Using this service may help lower the drug’s cost and allow you to get your medication without leaving home.

If you’re interested in this option, check with your doctor, pharmacist, or insurance company. Some Medicare plans may help cover the cost of mail-order medications.

Auvi-Q’s manufacturer also offers to ship Auvi-Q directly to your home if prescribed by your doctor. Bring this form to your doctor to learn more.

If you don’t have insurance, you can ask your doctor or pharmacist about online pharmacy options.

Generic version

Auvi-Q is available in a generic form called epinephrine. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. And generics tend to cost less than brand-name drugs.

If your doctor has prescribed Auvi-Q and you’re interested in using epinephrine instead, talk with them. They may have a preference for one version or the other. You’ll also need to check your insurance plan, as it may only cover one or the other.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosing to fit your needs.

Drug forms and strengths

Auvi-Q comes as an autoinjector that contains a single dose of the medication. The autoinjector is used to administer the medication by injection into your thigh. You can self-administer the injection, or someone else can do it for you. Your healthcare professional can teach you or your caregiver how to use Auvi-Q.

Auvi-Q comes in three strengths:

  • 0.1 milligrams epinephrine in 0.1 milliliters liquid solution (0.1 mg/0.1 mL)
  • 0.15 mg/0.15 mL
  • 0.3 mg/0.3 mL

Dosage for allergic reaction

The dose of Auvi-Q your doctor prescribes depends on your body weight, as shown in the dosage chart below:

Body weightRecommended dose
30 kg* (about 66 lb) or more0.3 mg
15 kg to 30 kg (about 33 lb to 66 lb)0.15 mg
7.5 kg to 15 kg (about 16.5 lb to 33 lb)0.1 mg

* One kg equals about 2.2 lb.

For example, if you weigh 55 kg (about 122 lb), the recommended dose to treat a severe allergic reaction is 0.3 mg. Your doctor will prescribe the 0.3 mg/0.3 mL strength of Auvi-Q autoinjector. This delivers an injection of 0.3 mg as a single dose. You should keep your Auvi-Q autoinjector with you at all times in case you need to treat an allergic reaction.

If you have symptoms of a severe allergic reaction, use the Auvi-Q autoinjector you’ve been prescribed. If your symptoms continue or come back after using one autoinjector, you can use a second autoinjector if it’s available. However, no more than two doses should be used without medical supervision.

After administering Auvi-Q, you should get emergency medical help right away. You may need further treatment for the allergic reaction.

Children’s dosage

Auvi-Q can be used to treat severe allergic reactions in children weighing at least 7.5 kg (about 16.5 lb). The dose your child’s doctor prescribes will depend on the child’s body weight. This is described above.

Auvi-Q is not suitable for infants weighing less than 7.5 kg (about 16.5 lb).

Will I need to use this drug long term?

If you and your doctor determine that Auvi-Q is safe and effective for you, you’ll likely use it whenever you need to treat a severe allergic reaction.

When you get Auvi-Q from the pharmacy, the pharmacist will add an expiration date to the label on the packaging. This date is typically 1 year from the date they dispensed the medication.

The expiration date helps guarantee that the medication is effective during this time. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. If you have unused medication that’s past the expiration date, ask your pharmacist how to correctly dispose of it.

Storage

How long a medication remains good to use can depend on many factors, including how and where you store the medication.

Auvi-Q autoinjector should be stored at room temperature. Keep it in the outer case it’s supplied in to protect it from light.

Disposal

After you’ve used an autoinjector, dispose of it immediately in an FDA-approved sharps disposal container. This helps prevent others, including children and pets, from taking the drug by accident or harming themselves with the needle. You can buy a sharps container online or ask your doctor, pharmacist, or health insurance company where to get one.

This article provides several useful tips on medication disposal. You can also ask your pharmacist for information about how to dispose of your medication.

Auvi-Q can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Auvi-Q. These lists do not include all possible side effects.

For more information about the possible side effects of Auvi-Q, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you’d like to notify the FDA about a side effect you’ve had with Auvi-Q, you can do so through MedWatch.

Mild side effects

Below is a partial list of mild side effects of Auvi-Q. To learn about other mild side effects, talk with your doctor or pharmacist, or view Auvi-Q’s prescribing information.

Mild side effects of Auvi-Q can include:

Most of these side effects may go away within a few minutes or hours. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.

* For more information about allergic reaction and Auvi-Q, see “Allergic reaction” below.

Serious side effects

Serious side effects from Auvi-Q aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

  • Serious skin and soft tissue infections at the injection site. Symptoms can include:
    • redness or discoloration at the injection site that doesn’t get better
    • warmth, swelling, or tenderness at the injection site that doesn’t get better
  • Severe allergic reaction.*

* For details about allergic reaction and Auvi-Q, see “Allergic reaction” below.

ALLERGIC REACTION

Even though Auvi-Q is used to treat severe allergic reactions, as with most drugs, some people can have an allergic reaction after taking Auvi-Q. Auvi-Q contains an inactive ingredient called sodium bisulfite, which can cause allergic reactions in some people. It’s not known how often this occurs.

Symptoms of a mild allergic reaction can include:

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under your skin, typically in your eyelids, lips, hands, or feet
  • swelling of your tongue, mouth, or throat
  • trouble breathing

Call your doctor right away if you have an allergic reaction to Auvi-Q, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

The Food and Drug Administration (FDA) approves prescription drugs such as Auvi-Q to treat certain conditions.

Auvi-Q for allergic reaction

Auvi-Q is FDA-approved for the emergency treatment of severe allergic reactions, including anaphylaxis.

If you’re at risk for severe allergic reactions, your doctor may prescribe Auvi-Q to keep with you at all times in case you have a severe allergic reaction.

Auvi-Q comes in strengths that are suitable for treating severe allergic reactions in adults, children, and infants weighing at least 7.5 kilograms* (about 16.5 lb).

* One kilogram (kg) equals about 2.2 pounds (lb).

Allergic reaction explained

An allergic reaction occurs when your immune system overreacts to a substance that it sees as harmful. Substances that cause allergic reactions are called allergens.

Examples of allergens that can cause allergic reactions include:

  • insect venom, for example, from bee or wasp stings or ant bites
  • foods, for example, nuts, shellfish, or eggs
  • latex
  • medications

Some allergic reactions can be severe or even life threatening. Anaphylaxis is a severe allergic reaction that comes on quickly. It can affect several parts of your body and can be life threatening if not treated.

Anaphylaxis is usually triggered by being exposed to an allergen. In some people, it can be triggered by vigorous exercise. More rarely, some people may have an anaphylactic reaction without obvious exposure to a trigger. If an allergy specialist can’t determine what causes you to have an anaphylactic reaction, this is called idiopathic anaphylaxis.

Symptoms of anaphylaxis can include:

  • itching or swelling of the lips, mouth, tongue, or throat
  • skin rash, swelling, or itching
  • swelling of the hands or feet
  • abdominal pain or cramps
  • nausea and vomiting
  • diarrhea
  • anxiety or a feeling of impending doom
  • dizziness
  • trouble swallowing
  • trouble breathing, shortness of breath, or wheezing
  • chest pain
  • weak pulse
  • loss of consciousness

If you’ve had a severe allergic reaction such as anaphylaxis, you’re at risk of having another. Auvi-Q is an injection that you can self-administer if you feel the symptoms of a severe allergic reaction coming on. Another person can also administer Auvi-Q for you.

Your healthcare professional can teach you how to use Auvi-Q. The device also gives electronic voice instructions in case it needs to be used by someone who hasn’t been trained on how to use it.

You should get emergency medical help immediately after using Auvi-Q. The allergic reaction could come back, and you may need further treatment.

You can learn more about allergic reactions by referring to our asthma and allergies hub.

Effectiveness for allergic reaction

Auvi-Q is an effective treatment for severe allergic reactions such as anaphylaxis.

The Asthma and Allergy Foundation of America (AAFA) notes that epinephrine is the most effective treatment for anaphylaxis. Auvi-Q is a self-injectable epinephrine medication. The AAFA recommends using a self-injectable epinephrine medication as soon as possible if you think you’re having an anaphylactic reaction.

Auvi-Q and children

Auvi-Q is FDA-approved to treat severe allergic reactions, including anaphylaxis, in children and infants weighing at least 7.5 kg (about 16.5 lb).

To read more about this use, see just above.

If you’ve been drinking alcohol, you can still use Auvi-Q to treat a severe allergic reaction. Auvi-Q doesn’t interact with alcohol.

Auvi-Q can interact with several other medications.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Drug-condition interactions can also cause certain effects. For information about these interactions, see the “Auvi-Q precautions” section below.

Auvi-Q and other medications

Below is a list of medications that can interact with Auvi-Q. This list doesn’t contain all drugs that may interact with Auvi-Q.

Before taking Auvi-Q, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Note that possible drug interactions shouldn’t stop you from using Auvi-Q to treat a severe allergic reaction. This is an emergency that can be life threatening. Always get emergency medical help immediately after using Auvi-Q.

Examples of drugs that can interact with Auvi-Q include:

  • Digoxin (Lanoxin). Digoxin is a heart medication. If you’re taking digoxin, you may have a raised risk for irregular heart rhythms with Auvi-Q.
  • Diuretics. Diuretics are drugs used to treat high blood pressure and fluid retention. If you’re taking a diuretic drug, you may have an increased risk for irregular heart rhythms with Auvi-Q. Examples of these drugs include:
  • Anti-arrhythmics. Anti-arrhythmics are drugs used to treat irregular heart rhythms. If you’re taking an anti-arrhythmic, you may have a raised risk for irregular heart rhythms with Auvi-Q. Examples of these drugs include:
    • amiodarone (Pacerone)
    • flecainide
  • Tricyclic antidepressants. Tricyclics are a type of antidepressant drug. If you’re taking a tricyclic antidepressant, you may have an increased risk for side effects with Auvi-Q. Examples of these drugs include:
  • Monoamine oxidase inhibitors (MAOIs). MAOIs are a type of antidepressant drug. If you’re taking an MAOI, you may have a raised risk for side effects with Auvi-Q. Examples of these drugs include:
    • phenelzine (Nardil)
    • tranylcypromine (Parnate)
  • Certain antihistamines. Antihistamines are drugs used to treat allergic reactions. If you’re taking an antihistamine, you may have an increased risk for irregular heart rhythms with Auvi-Q. Examples of these drugs include:
    • chlorpheniramine
    • diphenhydramine (Benadryl)
  • Levothyroxine (Synthroid). Levothyroxine is used to treat hypothyroidism (underactive thyroid gland). If you’re taking levothyroxine, you may have a raised risk for side effects with Auvi-Q.
  • Beta-blockers. These drugs are used to treat high blood pressure and angina. If you’re taking a beta-blocker, Auvi-Q may be less effective than usual. Examples of these drugs include:
  • Alpha-blockers. These drugs are used to treat high blood pressure. If you’re taking an alpha-blocker, Auvi-Q may be less effective than usual. Examples of these drugs include:
    • doxazosin (Cardura)
    • prazosin (Minipress)

Auvi-Q and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Auvi-Q. However, you should still check with your doctor or pharmacist before using any of these products.

Auvi-Q and foods

There aren’t any foods that have been specifically reported to interact with Auvi-Q. If you have any questions about eating certain foods, talk with your doctor.

You should take Auvi-Q according to the instructions your doctor gives you.

Auvi-Q comes as an autoinjector that contains a single dose of the medication. The autoinjector is used to administer the medication by injection into your thigh. You can self-administer Auvi-Q, or someone else can do it for you.

Your healthcare professional can teach you how to use Auvi-Q. The device also gives electronic voice instructions in case it needs to be used by someone who hasn’t been trained on how to use it.

Instructions for using Auvi-Q are provided with the medication. You can also find written instructions along with instruction videos on the manufacturer’s website.

Some key points to note include:

  • Auvi-Q should be administered in the middle of the outer thigh. The injection can be administered through clothes.
  • If you’re giving Auvi-Q to a young child, it’s important to hold their leg firmly during the injection to avoid injury. Your healthcare professional can show you how to do this.
  • Do not administer Auvi-Q into the buttock. It may not work to treat the allergic reaction if administered into the buttock.
  • Do not administer Auvi-Q into the fingers, toes, hands, or feet. Injecting the medication in these locations can stop blood flow to the injected area. If you accidentally inject Auvi-Q in these places, get emergency medical care right away.
  • Do not administer Auvi-Q into a vein. This could cause a sudden increase in blood pressure that causes bleeding in the brain. This could be life threatening.
  • You should get emergency medical help immediately after using Auvi-Q because the allergic reaction could return.

When to use

Talk with your doctor about when you should use Auvi-Q. Typically, you should use it as soon as you feel the symptoms of a severe allergic reaction coming on. Examples of these symptoms are listed in the “Auvi-Q uses” section above.

You should keep Auvi-Q with you at all times in case you need to treat an allergic reaction.

Accessible labels and containers

If your prescription label is hard to read, talk with your doctor or pharmacist. Some pharmacies offer labels that have large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist may be able to direct you to one that does.

Auvi-Q is used for the emergency treatment of severe allergic reactions, such as anaphylaxis.

What happens with severe allergic reactions

A severe allergic reaction occurs when your immune system overreacts to a substance that it sees as harmful. In this situation, your immune system releases large amounts of signaling molecules, such as histamine. These molecules produce inflammatory responses that aim to isolate the substance or remove it from your body.

These responses may cause:

  • leaking from blood vessels, which causes swelling in your mouth, tongue, throat, hands, feet, or skin
  • narrowing of your airways, which can cause trouble breathing
  • rash or itching
  • vomiting or diarrhea
  • abdominal pain or cramps
  • dilation (widening) of blood vessels, which lowers your blood pressure, causing dizziness or fainting
  • a weak, rapid pulse
  • shock (a condition where your heart can’t effectively pump blood around your body)

A severe allergic reaction can be life threatening if it’s not treated.

What Auvi-Q does

Auvi-Q contains the active drug epinephrine, which is also called adrenaline. Epinephrine is a hormone and neurotransmitter that’s found naturally in your body. (Neurotransmitters are chemicals that pass messages between nerves and other tissues in your body.) Epinephrine is responsible for producing your body’s natural “fight or flight” response.

Epinephrine causes the following effects, which help reverse the symptoms of severe allergic reactions:

  • narrowing of your blood vessels, which stops them from leaking and increases your blood pressure
  • increased rate and strength of your heartbeat, which helps it pump blood around your body effectively
  • widening of your airways, which helps you breathe
  • relaxing of the muscles in your stomach and intestine, which relieves cramps, vomiting, and diarrhea

How long does it take to work?

Auvi-Q usually works within a few minutes of using the injection. If one dose doesn’t work or your symptoms come back, a second dose can be used if available.

It’s important to get emergency medical help immediately after using Auvi-Q because the allergic reaction could return. You may need further treatment.

Auvi-Q hasn’t been studied during pregnancy. However, Auvi-Q is used for emergency treatment of severe allergic reactions, such as anaphylaxis.

An anaphylactic reaction during pregnancy can be life threatening for the pregnant person and the fetus. For this reason, Auvi-Q can be used to treat severe allergic reactions that happen during pregnancy. Its benefits usually outweigh any risks.

If you’re pregnant, be sure to talk with your doctor about when you should use Auvi-Q. Always get emergency medical help immediately after using Auvi-Q.

Auvi-Q can be used to treat severe allergic reactions that occur during pregnancy. However, an anaphylactic reaction during pregnancy could be life threatening for the pregnant person and the fetus.

If you’re at risk of anaphylactic reactions, you’re sexually active, and you or your partner can become pregnant, talk with your doctor about your birth control needs.

For more information about taking Auvi-Q during pregnancy, see the “Auvi-Q and pregnancy” section above.

It’s not known if Auvi-Q passes into breast milk. However, Auvi-Q is used for emergency treatment of severe allergic reactions, which can be life threatening. For this reason, Auvi-Q can be used by people who are breastfeeding.

Auvi-Q is rapidly removed from your body. If you’re breastfeeding and take a dose of Auvi-Q, talk with your doctor about when you can safely breastfeed afterward.

This drug comes with several precautions. These are considered drug-condition interactions.

Before taking Auvi-Q, talk with your doctor about your health history. Auvi-Q may not be right for you if you have certain medical conditions or other factors affecting your health. However, Auvi-Q is used for emergency treatment of severe allergic reactions, which can be life threatening. So, its benefits usually outweigh its risks. Factors that should be considered include:

  • Allergic reaction. If you’ve had an allergic reaction to Auvi-Q or any of its ingredients, your doctor may not prescribe Auvi-Q. Ask your doctor if other medications may be better options for you. However, in most instances, the benefits of using Auvi-Q to treat a life threatening allergic reaction outweigh the risks, even if you’re allergic to certain ingredients in Auvi-Q. Always seek emergency medical help immediately after using Auvi-Q.
  • Heart disease or high blood pressure. Auvi-Q increases your heart rate and blood pressure. If you have heart disease or high blood pressure, Auvi-Q could cause chest pain or irregular heartbeats. Due to this risk, it’s important to only use Auvi-Q if you’re having a life threatening allergic reaction. Talk with your doctor about when you should use Auvi-Q. Always get emergency medical help immediately after using Auvi-Q.
  • Hyperthyroidism. If you have hyperthyroidism (high levels of thyroid hormones), Auvi-Q could temporarily worsen your symptoms. Always get emergency medical help immediately after using Auvi-Q.
  • Diabetes. If you have diabetes, Auvi-Q could temporarily make your symptoms worse. Always get emergency medical help immediately after using Auvi-Q. If you have diabetes, talk with your doctor about when you should use Auvi-Q.
  • Parkinson’s disease. If you have Parkinson’s disease, Auvi-Q could temporarily worsen your symptoms. Always get emergency medical help immediately after using Auvi-Q. If you have Parkinson’s disease, talk with your doctor about when you should use Auvi-Q.
  • Pregnancy. Auvi-Q can be used during pregnancy. Always get emergency medical help immediately after using Auvi-Q. For more information, see the “Auvi-Q and pregnancy” section above.
  • Breastfeeding. It’s not known if Auvi-Q passes into breast milk. However, Auvi-Q can be used by people who are breastfeeding. For more information, see the “Auvi-Q and breastfeeding” section above.

Note: For more information about the potential negative effects of Auvi-Q, see the “Auvi-Q side effects” section above.

Using more than the recommended dosage of Auvi-Q can lead to serious side effects. Do not use more Auvi-Q than your doctor recommends. (For information on the recommended dosages of Auvi-Q, see the “Auvi-Q dosage” section above.)

Overdose symptoms

Symptoms of an overdose can include:

What to do in case of overdose

If you think you’ve used too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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