Glucagon-like peptide-1 (GLP-1) receptor agonists were originally prescribed for type 2 diabetes (T2D), but several are now specifically approved for long-term weight management.
Comparing how well they promote weight loss may help you decide which one is right for you. Here, we look at data from clinical trials and discuss other factors to consider when choosing a GLP-1 medication.
In a 2026 review of 16 clinical trials, about 78.5% of people taking GLP-1 medications achieved weight loss, compared with only 26.5% of those taking a placebo.
The researchers found that some GLP-1 medications are more effective at helping people lose weight than others. Tirzepatide (Mounjaro, Zepbound) and semaglutide (Ozempic, Wegovy) are currently the top-performing options.
The table below compares the average body weight loss reported in clinical trials.
It’s important to note that weight loss varies depending on a person’s starting weight, the condition they’re treating, and the duration of GLP-1 use, which the data below do not show. Still, you can use this table as a rough guide.
| GLP-1 medication | % of body weight lost |
|---|---|
| tirzepatide (Mounjaro, Zepbound) | 15% to 21% |
| semaglutide (Ozempic, Wegovy) | 10% to 15% |
| liraglutide (Saxenda, Victoza) | 12.4% |
| orforglipron (Foundayo) | 11.2% |
| dulaglutide (Trulicity) | 2.6% to 5.8% |
There may be other GLP-1 medications available soon that are even more effective at helping people lose weight. New “multi-receptor” agonists are still in development and show great potential. Examples include:
- Mazdutide: This targets GLP-1 and glucagon receptors.
- Retatrutide: This targets receptors of GLP-1, gastric inhibitory polypeptide (GIP), and glucagon.
- CagriSema: This combines semaglutide (a GLP-1 receptor agonist) and cagrilintide (a long-acting amylin analog).
If you’re considering trying a GLP-1 medication for weight loss, talk with your doctor about your options. A drug’s side effect profile, method of delivery, and cost may also be important variables.
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