Daytrana (methylphenidate)

Daytrana generic

Daytrana is a brand-name drug that contains the active drug methylphenidate. This active drug is also available as a generic medication. A generic drug is an exact copy of the active drug in a brand-name medication.

The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.

If you’re interested in the generic form of Daytrana, talk with your doctor. They can tell you whether it comes in forms and strengths that could work for your condition.

Daytrana side effects

Daytrana can cause mild or serious side effects. The following lists contain some of the key side effects that may occur with Daytrana. These lists do not include all possible side effects.

For more information about the possible side effects of Daytrana, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect of Daytrana, you can do so through MedWatch.

Mild side effects

Below is a partial list of mild side effects of Daytrana. To learn about other mild side effects, talk with your doctor or pharmacist, or view Daytrana’s prescribing information.

Mild side effects of Daytrana can include:

• decreased appetite or loss of appetite
• trouble sleeping
• nausea
• vomiting
• weight loss
• tics
• labile affect (changes in mood and emotional responses that are different or more intense than expected)
• dizziness
• abdominal pain
• headache
• mild skin reaction where the patch was applied, such as itching, small bumps, or discoloration
• mild allergic reaction*

Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.

* For more information about allergic reaction and Daytrana, see “Allergic reaction” below.

Serious side effects

Serious side effects from Daytrana aren’t common. However, they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects that occurred in Daytrana’s clinical trials include:

• Increased heart rate. Symptoms may include:
  • rapid heart rate
  • dizziness
  • feeling as though your heart is pounding
• Mania (extremely heightened energy or dramatic changes in behavior and thoughts). Symptoms can include:
  • being very talkative or speaking very quickly
  • racing thoughts
  • having extremely high energy
  • feelings of euphoria or invincibility
• Psychosis (losing touch with reality). Symptoms can include:
  • feeling suspicious or uneasy around others
  • hearing voices that aren’t actually there
  • lacking emotions or having trouble regulating them
  • a noticeable drop in school or work performance
• Seizure. Symptoms can include:
  • jerky movements or muscle spasms
  • loss of response or awareness
  • staring into space
  • a dazed or confused state
  • shaking or twitching
• Priapism (a prolonged, painful erection that doesn’t go away). Symptoms can include:
  • penile pain that worsens with time
  • an erection that doesn’t go away
• Blood vessel problems, including Raynaud’s disease. Symptoms can include:
  • fingers or toes that are cold or numb
  • fingers or toes that turn white then blue
  • experiencing a numb, stinging, or prickly sensation when warming your fingers or toes
• High pressure in your eye or angle-closure glaucoma. Symptoms can include:
  • severe pain in one eye
  • blurred vision
  • headache
  • nausea
  • vomiting
• Increased blood pressure. This may not cause noticeable symptoms unless it becomes severe. Possible severe symptoms can include:
  • headache
  • nausea and vomiting
  • blurred vision
  • dizziness
• Slowed growth rate (a child not gaining the expected weight or height for their age).
• Long-term changes in or loss of skin pigment, including at skin sites where Daytrana is not applied.
• Risk of misuse and addiction.*
• Severe allergic reaction, including serious skin reaction.†

* Daytrana has boxed warnings about this. Boxed warnings are the most serious warnings from the FDA. To learn more, see the “Daytrana precautions” section below.
† For details about allergic reaction and Daytrana, see “Allergic reaction” below.

ALLERGIC REACTION

As with most drugs, some people can have an allergic reaction after applying Daytrana. This was a very rare side effect in clinical trials of this drug.

Symptoms of a mild allergic reaction can include:

• skin rash
• itchiness
• flushing

A more severe allergic reaction is rare. However, it is possible. Symptoms of a severe allergic reaction can include:

• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your tongue, mouth, or throat
• trouble breathing

Call your doctor right away if you have an allergic reaction to Daytrana, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Daytrana dosage

The Daytrana dosage the doctor prescribes will depend on the severity of your attention deficit hyperactivity disorder (ADHD) and how your symptoms respond to Daytrana.

Typically, your doctor will start by prescribing a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly prescribed or recommended. However, be sure to follow the dosage your doctor prescribes for you. Your doctor will determine the best dosage schedule to fit your needs.

Drug forms and strengths

Daytrana comes as a transdermal patch that you apply to your skin. (Transdermal means the active drug is absorbed through your skin.) The patch provides a steady amount of the drug for up to a 9-hour period.

Daytrana comes in four strengths, all of which release the drug over a 9-hour period:

• 10 milligrams (mg)
• 15 mg
• 20 mg
• 30 mg

Dosage for ADHD

Your doctor will likely prescribe the 10-mg Daytrana patch to start. This is the typical starting dose regardless of whether you’ve taken other drugs containing methylphenidate in the past. (Methylphenidate is the active drug in Daytrana. This active drug is also available in other forms and brands.)

You’ll apply one patch to your skin and leave it in place for up to 9 hours, according to your doctor’s instructions.

Your doctor may increase your dose each week until they determine the amount that’s right for you. The maximum dosage is the 30-mg patch, applied to the skin for up to 9 hours.

For more details about Daytrana’s dosage, you can refer to this article.

What if I miss a dose?

Typically, you’ll apply Daytrana early in the morning, about 2 hours before you go to school. (Daytrana is prescribed to treat ADHD in children and adolescents ages 6 to 17 years.) The patch is left in place for up to 9 hours, according to the doctor’s instructions. Daytrana comes with a 9-hour dosing chart that shows what time you’d usually remove Daytrana, based on when you apply the patch.

If you forget to apply Daytrana at the regular time, it can be applied as soon as you remember, before going to school. Even if you apply the patch later than usual, it should still come off at the regular time. Leaving the patch on too late in the day can increase the risk of bothersome side effects, such as trouble sleeping.

If you forget to apply Daytrana in the morning or before going to school, do not apply it when you get home. This is because the patch takes about 2 hours to start working, and wearing the patch too late in the day can lead to trouble sleeping. Instead, apply the Daytrana patch at the regular time the next morning, about 2 hours before going to school.

Talk with the doctor or pharmacist if you have questions about what to do about missing a dose of Daytrana.

To help make sure you don’t miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

Will I need to apply Daytrana patches long term?

Daytrana is meant to be a long-term treatment. If you and your doctor determine that Daytrana is safe and effective, you’ll likely apply the patches long term.

Daytrana cost and savings

As with all medications, the cost of Daytrana can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Drug coupons. You can visit Optum Perks for price estimates of Daytrana. These estimates are based on the use of Optum Perks coupons. Note: Optum Perks coupons cannot be used with insurance copays or benefits.

Financial and insurance assistance. If you need financial support to pay for Daytrana, or if you need help understanding your insurance coverage, help is available.

Daytrana has a copay program that can help with the cost of the drug with or without insurance. For more information and to find out whether you’re eligible for support, call 833-483-2178 or visit the program website.

Generic version. Daytrana is available in a generic form called methylphenidate transdermal patch. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. And generics tend to cost less than brand-name drugs. To find out how the cost of the methylphenidate transdermal patch compares to the cost of Daytrana, talk with your doctor or pharmacist.

To learn more about saving money on prescriptions, check out this article.

Save on your Daytrana prescription

Save on Daytrana without insurance.

Enter your information:

Location

47201

Dosage

30 methylphenidate hcl (2 Boxes)

Save money without using insurance

Simply show the Optum Perks coupon at your preferred pharmacy or order online and instantly save up to 80% without using insurance. The coupon doesn't expire, so be sure to save it for refills.

Find your pharmacy

SEARCH

advertisement

SEE MORE RESULTS

Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

Optum Perks and Healthline are subsidiaries of RVO Health.

Pricing source:Perks.optum.com

---

Was this helpful?

Common questions about Daytrana

Here are answers to some frequently asked questions about Daytrana.

Is Daytrana prescribed for adults?

Daytrana is only approved by the Food and Drug Administration (FDA) to treat attention deficit hyperactivity disorder (ADHD) in children and adolescents ages 6 to 17 years. It isn’t approved for use in adults with ADHD.

Other medications that contain methylphenidate are approved for treating ADHD in adults, such as Ritalin and Concerta. For adults interested in a patch form of an ADHD medication, a brand-name medication called Xelstrym is available. It contains the active drug dextroamphetamine and is approved to treat ADHD in adults and some children.

Doctors might prescribe Daytrana for adults. However, this is an off-label use. (Off-label use is when a drug is prescribed for a purpose other than its FDA-approved uses.) Talk with your doctor if you have questions about Daytrana’s effectiveness or side effects in adults with ADHD.

Can I apply the Daytrana patch on my shoulder?

It’s not recommended. Daytrana should only be applied to the skin of the hip area.

Application sites other than the hips might cause differences in absorption and could change the drug’s expected effects in the body. Only the hip area was studied and found to be safe and effective in the drug’s clinical trials for ADHD. Placing the Daytrana patch on any location other than your hip could also cause side effects, including:

• mild skin reaction where the patch was applied, such as itching, small bumps, or discoloration
• long-term changes in or loss of skin pigment

If you have questions about where to place your Daytrana patch, talk with your doctor or pharmacist.

Could Daytrana make you feel ‘high’?

Daytrana should not make you feel “high” if you apply it according to your doctor’s instructions. However, an overdose of Daytrana could make you feel high, among other symptoms, some of which can be serious.

For more information about overdoses of Daytrana, see the “Daytrana overdose” section below.

Is Daytrana a stimulant?

Yes, Daytrana is a stimulant. It belongs to a drug class called central nervous system (CNS) stimulants. Stimulants work by increasing the activity of the CNS, which includes the brain and nerves.

Some examples of other ADHD medications that are stimulants include amphetamine/dextroamphetamine (Adderall) and dexmethylphenidate (Focalin). Other stimulants include caffeine, nicotine, and cocaine.

If you have additional questions about Daytrana, talk with your doctor or pharmacist.

Alternatives to Daytrana

Other drugs are available that can treat your condition. Some may be a better fit for you than others. If you’re interested in finding an alternative to Daytrana, talk with your doctor. They can tell you about other medications that may work well for you.

Note: Some of the drugs listed here are prescribed off-label to treat these specific conditions. Off-label drug use is when a drug that’s approved by the Food and Drug Administration (FDA) is prescribed for a purpose other than what it’s approved for.

Daytrana is a transdermal patch that contains the active drug methylphenidate. This active drug is available in several other forms and brands, such as:

• an immediate-release oral tablet (Ritalin)
• an extended-release oral tablet (Concerta)
• an extended-release oral capsule (Jornay PM, Metadate CD, Ritalin LA)
• an oral solution (Methylin)
• an oral liquid suspension (Quillivant XR)
• a chewable extended-release tablet (Quillichew ER)
• an orally dissolving tablet (Cotempla XR-ODT)

Examples of other drugs that may be used to treat attention deficit hyperactivity disorder (ADHD) include:

• amphetamine (Evekeo, Dyanavel XR)
• amphetamine/dextroamphetamine (Adderall, Adderall XR, Mydayis)
• atomoxetine (Strattera)
• clonidine (Kapvay)
• dexmethylphenidate (Focalin, Focalin XR)
• dextroamphetamine (Dexedrine)
• lisdexamfetamine (Vyvanse)
• viloxazine (Qelbree)

Daytrana uses

The Food and Drug Administration (FDA) approves prescription drugs such as Daytrana to treat certain conditions. Daytrana may also be prescribed off-label for other conditions. Off-label drug use is when an FDA-approved drug is prescribed for a purpose other than what it’s approved for.

Daytrana for attention deficit hyperactivity disorder (ADHD)

Daytrana is FDA-approved to treat ADHD in children and adolescents ages 6 to 17 years.

ADHD explained

ADHD is a mental health condition that commonly affects children. ADHD can affect a child’s behavior, social skills, and academic performance.

Symptoms of ADHD may include:

• difficulty focusing on a task
• being easily distracted
• losing or forgetting things often
• difficulty sitting still
• difficulty being patient
• impulsivity (acting without thinking about the possible consequences)
• difficulty getting organized and meeting deadlines

You can learn more about your condition in our ADHD hub and mental health hub.

Effectiveness for ADHD

Daytrana has been shown to be an effective treatment for ADHD in children and adolescents ages 6 to 17 years. The American Academy of Pediatrics includes methylphenidate (the active drug in Daytrana) as a treatment option in their guidelines for ADHD treatment in children and adolescents.

For details on how Daytrana performed in clinical trials, see the drug’s prescribing information.

How Daytrana works

Daytrana is prescribed to treat attention deficit hyperactivity disorder (ADHD) in children and adolescents ages 6 to 17 years. It’s a stimulant drug that works by increasing the activity of the central nervous system.

Stimulants are thought to increase the levels of norepinephrine and dopamine in the brain. Both of these chemicals are involved in focus and attention. It’s thought that Daytrana helps improve focus and other symptoms of ADHD by increasing levels of norepinephrine and dopamine in your brain.

How long does it take to work?

Daytrana takes about 2 hours to start working after you apply the patch to the skin of the hip area. The drug lasts for up to 9 hours. The patch should be removed no longer than 9 hours after the time you applied it to your skin.

How to apply Daytrana

You should apply Daytrana according to the instructions your doctor gives you.

You’ll apply a Daytrana patch to the skin of the hip area. Choose an area of skin that’s clean and dry and won’t rub against clothing.

Here are the basic steps for applying and removing Daytrana:

1. Remove the patch from its pouch and gently peel back half of the protective liner. Try to avoid touching the sticky side of the patch.
2. Place the sticky side of the patch on the hip and smooth it down. Using the palm of your hand, press the patch firmly into place for about 30 seconds. Be sure to alternate hips each day.
3. Note the time that you apply the Daytrana patch so that you can remove it 9 hours later (or however long your doctor prescribes).
4. After 9 hours (or less), remove the Daytrana patch by peeling it off slowly. If it’s stuck, try spreading an oil-based product, such as petroleum jelly, to the patch edges to help loosen it. Once it’s removed, fold the patch in half and dispose of it.

Wash your hands after applying and removing a Daytrana patch.

Detailed instructions are also enclosed in the drug’s packaging and on the manufacturer’s website. Parents or caregivers should assist young children in applying Daytrana.

When to apply

Typically, you’ll apply Daytrana early in the morning, about 2 hours before going to school. (Daytrana is prescribed to treat attention deficit hyperactivity disorder (ADHD) in children and adolescents ages 6 to 17 years.) You’ll leave it in place for up to 9 hours, according to your doctor’s instructions.

Daytrana comes with a 9-hour dosing chart that shows what time you should remove Daytrana, based on when you apply the patch.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Accessible labels and containers

Some pharmacies offer labels that have large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist may be able to direct you to one that does.

Daytrana and alcohol

Daytrana isn’t known to interact with alcohol. However, drinking alcohol is not recommended during Daytrana treatment.

Daytrana is prescribed for children and adolescents ages 6 to 17 years with attention deficit hyperactivity disorder (ADHD). Alcohol should not be consumed before age 21 years in the United States.

Heavy alcohol use can lead to alcohol use disorder. And Daytrana typically isn’t prescribed to people with dependence or substance use disorder, including alcohol use disorder. This is because Daytrana has boxed warnings* about a high risk of misuse and addiction.

If you have questions about drinking alcohol during Daytrana treatment, talk with your doctor or pharmacist.

* Boxed warnings are the most serious warnings from the Food and Drug Administration (FDA). To learn more about this, see the “Daytrana withdrawal and dependence” section below.

Daytrana interactions

Daytrana can interact with several other medications and certain supplements.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Drug-condition interactions can also cause certain effects. For information about these interactions, see the “Daytrana precautions” section below.

Daytrana and other medications

Below is a list of medications that can interact with Daytrana. This list does not contain all drugs that may interact with Daytrana.

Before starting treatment with Daytrana, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also, tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

Similar to other stimulants, Daytrana may cause increases in heart rate and blood pressure. Due to this risk, doctors do not prescribe Daytrana with medications from a drug class called monoamine oxidase inhibitors (MAOIs). Also, doctors will not prescribe Daytrana if you’ve stopped taking an MAOI within the past 14 days. Taking these drugs together (or within 14 days of each other) could cause dangerously high blood pressure. This may result in stroke, heart attack, or other life threatening complications.

Examples of MAOIs include:

• tranylcypromine (Parnate)
• selegiline (Emsam, Zelapar)
• phenelzine (Nardil)
• linezolid (Zyvox)
• isocarboxazid (Marplan)

In addition, Daytrana can make blood pressure medications less effective at managing blood pressure. This is because Daytrana may increase blood pressure. If your doctor prescribes Daytrana and you’re also taking blood pressure medication, they may have you check your blood pressure at home to make sure it isn’t worsening.

Examples of blood pressure medications include:

• beta-blockers, such as metoprolol (Toprol XL, Lopressor)
• angiotensin converting enzyme inhibitors, such as lisinopril (Zestril)
• angiotensin receptor blockers, such as valsartan (Diovan)
• diuretics, such as hydrochlorothiazide (Microzide)
• calcium channel blockers, such as verapamil (Verelan)

Daytrana may also affect how the body metabolizes (breaks down) certain other medications. This could lead to increased severity or frequency of side effects from these other medications. Your doctor may adjust or decrease your dosage if they prescribe any of the following types of medication for you during your Daytrana treatment:

• warfarin (Jantoven)
• anticonvulsants (also known as antiepileptic drugs), such as phenobarbital, phenytoin (Dilantin), and primidone (Mysoline)
• selective serotonin reuptake inhibitors, such as fluoxetine (Prozac) and sertraline (Zoloft)
• risperidone (Risperdal)

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Daytrana and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Daytrana. However, you should still check with your doctor or pharmacist before using any of these products during treatment with Daytrana.

Daytrana and foods

Daytrana is a patch that delivers medication through your skin. This medication isn’t expected to be affected by food.

No foods have been reported to interact with Daytrana. If you have any questions about eating certain foods with Daytrana, talk with your doctor.

Daytrana and pregnancy

It’s not known whether Daytrana treatment is safe during pregnancy. The drug’s effects haven’t been clinically studied in people who are pregnant.

In animal studies, the drug caused harmful effects in pregnant animals and their fetuses. Keep in mind that the findings of animal studies don’t always predict what will happen in humans.

However, because of the risk of harm, it’s likely that your doctor will not prescribe Daytrana if you’re pregnant. And they’ll likely have you stop treatment with Daytrana if you become pregnant during treatment.

Talk with your doctor if you have additional questions about Daytrana during pregnancy.

Pregnancy registry

There is a pregnancy registry that monitors pregnancy outcomes of people who use Daytrana while pregnant. This registry helps doctors and consumers learn more about possible drug effects during pregnancy. If you become pregnant during Daytrana treatment, your doctor may encourage you to visit the website or call 866-961-2388.

Daytrana and birth control

It’s not known whether Daytrana treatment is safe during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs during Daytrana treatment.

For more information about Daytrana treatment during pregnancy, see the “Daytrana and pregnancy” section above.

Daytrana and breastfeeding

It’s not known whether Daytrana treatment is safe while breastfeeding. The drug’s use hasn’t been formally clinically studied in people who are breastfeeding.

A limited number of reports have found that the drug passes into breast milk. It’s possible that a child may be exposed to the drug if they are breastfed by a person being treated with Daytrana. This could lead to side effects in the child, such as trouble sleeping, agitation, loss of appetite, and not gaining weight as expected.

If you’re breastfeeding or considering it, talk with your doctor before starting Daytrana. They’ll help you weigh the risks and benefits and advise you on safe ways to feed your child.

Daytrana precautions

This drug comes with several precautions. These are known as drug-condition interactions.

FDA warning: Risk of misuse (also called abuse) and addiction

This drug has boxed warnings about a high risk of misuse and addiction. Boxed warnings are serious warnings from the Food and Drug Administration (FDA). They alert doctors and patients about drug effects that may be dangerous.

With misuse, a drug is used differently than how it’s prescribed. (For example, Daytrana might be applied more often or for longer than prescribed.) With addiction or a substance use disorder, a drug is used even if it causes harmful outcomes. Misuse and addiction increase the risk of overdose and even death.

Episodes of psychosis (loss of touch with reality) have occurred in people who have misused methylphenidate (the active drug in Daytrana) by injecting it. Also, stopping Daytrana after misusing it may lead to severe depression in some people.

Due to these risks, Daytrana is a controlled substance. Controlled substances are strictly regulated by the government. Specifically, Daytrana is a Schedule II controlled substance. Drugs in this category have an accepted medical use. However, they also carry a high risk of physical or psychological dependence. Because of this, the government has passed strict laws that regulate how Schedule II drugs are prescribed and dispensed. Your doctor or pharmacist can tell you more about this.

Because of these boxed warnings, doctors will likely not prescribe Daytrana to treat conditions in people with a history of dependence or substance use disorder.

Before prescribing Daytrana, you and your doctor will discuss the risks of Daytrana treatment. While you’re using Daytrana, they may evaluate you for any signs of misuse or addiction.

You should store Daytrana in a safe place and only use the drug as your doctor prescribes it. Do not give Daytrana to anyone else. See “Daytrana expiration, storage, and disposal” below for details about how to safely store and dispose of the drug.

Other precautions

Before starting Daytrana, talk with your doctor about your health history. Daytrana may not be right for you if you have certain medical conditions or other factors affecting your health. These include:

• History of substance use disorder or drug misuse. If you have a history of substance use disorder or drug misuse, your doctor may not prescribe Daytrana for you. This is due to Daytrana’s high risk of misuse and addiction, which the drug has boxed warnings for (see above). Your doctor might recommend a different treatment instead of Daytrana. If they do prescribe Daytrana, they’ll likely monitor you frequently for any signs of misuse or addiction.
• Serious heart problems. If you have serious heart problems, your doctor may not prescribe Daytrana. Sudden death has been reported in people with serious heart problems who took central nervous system (CNS) stimulants such as Daytrana. These heart problems included abnormal heart structure, serious arrhythmia, coronary artery disease, and cardiomyopathy.
• Severe anxiety, agitation, or tension. Having severe anxiety, agitation, or tension could prevent your doctor from prescribing Daytrana due to a risk of harm. If you have any of these conditions, talk with your doctor before starting treatment with Daytrana.
• Tourette syndrome or tics. Daytrana may cause tics as a side effect. If you already have tics or Tourette syndrome, Daytrana may worsen your symptoms. Doctors typically will not prescribe Daytrana to people with this condition due to a risk of harm. Be sure to tell your doctor if you have a family history of Tourette syndrome or tics.
• Heart or blood pressure problems. Daytrana may increase heart rate or blood pressure. If you have a heart or blood pressure condition that could be worsened by these side effects, your doctor may not prescribe Daytrana. If they do, they may have you check your blood pressure at home to make sure it isn’t increasing. High blood pressure could lead to serious cardiovascular events such as heart attack or stroke.
• Glaucoma or high eye pressure. If you have glaucoma or high pressure in your eye, Daytrana may make this condition worse. Due to this risk, doctors typically will not prescribe Daytrana to people with glaucoma. And if you have an increased risk of angle-closure glaucoma (such as if you have severe farsightedness), you may need to be evaluated by an eye doctor before starting Daytrana treatment.
• Bipolar disorder or other mental health conditions. If you have bipolar disorder or other mental health conditions, or if you experience psychosis or mania, treatment with Daytrana may worsen your condition. If your doctor prescribes Daytrana for you, they’ll likely monitor you closely for unusual patterns in your mood or behavior.
• Seizures. Daytrana may cause seizures. If you have epilepsy (seizure disorder) or another condition that increases the risk of seizure, Daytrana may not be safe for you. Your doctor can help determine the attention deficit hyperactivity disorder (ADHD) treatment that is right for you.
• Blood circulation problems, such as Raynaud’s disease. Daytrana may cause problems with circulation in your blood vessels, including Raynaud’s disease. If you have a blood circulation problem, Daytrana treatment could worsen your condition. Ask your doctor whether other medications may be better options for you. If Daytrana is prescribed to you, your doctor will closely monitor your circulation problems during treatment.
• Allergic reaction. If you’ve had an allergic reaction to Daytrana or any of its ingredients, your doctor will not prescribe Daytrana. Ask your doctor what other medications may be better options for you.
• Pregnancy. It’s not known whether Daytrana treatment is safe during pregnancy. For more information, see the “Daytrana and pregnancy” section above.
• Breastfeeding. It’s not known whether Daytrana treatment is safe while breastfeeding. For more information, see the “Daytrana and breastfeeding” section above.

Note: For more information about the potential negative effects of Daytrana, see the “Daytrana side effects” section above.

Daytrana overdose

Applying more than the recommended dosage of Daytrana can lead to serious side effects. Do not apply more Daytrana than your doctor recommends. (For information on the recommended dosages of Daytrana, see the “Daytrana dosage” section above.)

While wearing the Daytrana patch, it’s important to avoid exposing the application site to sources of heat. Examples include heating pads, hair dryers, and electric blankets. Heat exposure can increase or even double the amount of the medication that absorbs into your body from the Daytrana patch. This can lead to overdose.

Overdose symptoms

Symptoms of an overdose can include:

• vomiting
• agitation (feeling annoyed or restless)
• tremors
• muscle twitching
• convulsions
• coma
• euphoria (feeling “high”)
• confusion
• hallucinations
• sweating
• flushing
• changes in heart rate or rhythm
• high blood pressure
• rhabdomyolysis (muscle breakdown that can lead to kidney damage)

What to do in case of overdose

If you think you’ve received too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.

Daytrana withdrawal and dependence

Daytrana can cause drug dependence. With dependence, your body needs the drug to feel as you typically would. In some cases, dependence can lead to misuse (using a drug differently than how it’s prescribed) and addiction (using the drug even if it causes harmful outcomes). Daytrana has a boxed warning* about a high risk of misuse and addiction.

Daytrana should be prescribed with caution to people with a history of dependence or substance use disorder. Regular Daytrana treatment can lead to tolerance and dependence. (With tolerance, you may no longer respond to the typical dose of a drug, and a higher dose may be needed to have an effect.)

If there is a history of dependence or substance use disorder and a doctor prescribes Daytrana, they may monitor the person frequently during Daytrana treatment.

It’s possible to experience withdrawal after stopping Daytrana treatment. Withdrawal refers to negative effects that can occur when you stop taking a drug your body has become dependent on. Withdrawal symptoms can include mood changes, unusual dreams, increased appetite, slow movements, and sleeping too much or too little. To help avoid withdrawal symptoms when stopping Daytrana treatment, a doctor may reduce the dosage of Daytrana gradually over time.

It’s also important to note that symptoms of ADHD may return or worsen after stopping Daytrana. If you stop Daytrana treatment, talk with your doctor about other treatment options.

* This is a serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous. See the “Daytrana precautions” section above for details.