Dificid (fidaxomicin) is a brand-name drug prescribed for diarrhea caused by Clostridioides difficile (C. diff). It’s available as an oral tablet and oral liquid suspension. The cost of Dificid with and without insurance can depend on several factors.

Specifically, the Food and Drug Administration (FDA) has approved Dificid for C. diff-associated diarrhea in adults and children ages 6 months and older.

Dificid retail price
$4981
Save up to $153 per fill off of the retail price
The retail price of Dificid is $4981. Save up to $153 per fill off of the retail price.

As with all medications, the cost of Dificid can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • whether Dificid has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Dificid will be for you, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your Dificid prescription, explore these Optum Perks coupons.

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Dificid is only available as a brand-name drug. It doesn’t come in a generic version. A generic drug is an exact copy of the active drug in a brand-name medication.

Generics tend to cost less than brand-name drugs.

WHY ARE COSTS DIFFERENT FOR BRAND-NAME DRUGS VS. GENERIC DRUGS?

Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions. This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

If you need financial support to pay for Dificid, or if you need help understanding your insurance coverage, help is available. For example:

  • A coupon is available for Dificid. For more information and to find out whether you’re eligible for support, call 877-264-2454 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Here are answers to some frequently asked questions about drug cost and Dificid.

How much does Dificid cost with insurance vs. without it?

What you pay for Dificid if you have insurance compared with what you’d pay without it depends on several factors.

Factors that could affect what you pay for this drug without insurance include:

  • whether you apply and qualify for any available savings programs
  • your dosage and treatment plan
  • the pharmacy you use
  • the form of the drug you’re prescribed (such as the oral tablet or liquid suspension)

These same factors may affect your price for Dificid if you have insurance. But the price you pay with insurance will also depend on:

  • your specific plan benefits
  • any prior authorization requirements you have for drug coverage

To learn more about what you’d pay for Dificid with or without insurance, talk with your doctor, pharmacist, or insurance provider (if you have one).

You can also visit Optum Perks* for price estimates for this drug when using coupons from their site. However, Optum Perks coupons cannot be used with insurance benefits or copays.

* Optum Perks is a sister site of Medical News Today.

Is Dificid covered by Medicare?

It may be. You can call your Medicare plan provider to learn whether your particular plan covers the cost of this drug. There are many types of Medicare plans, so your coverage and what you pay for prescriptions will be based on your particular plan’s benefits.

You may also need to obtain prior authorization before your plan will cover the cost of this medication.

Your doctor may also be able to provide information about your cost for Dificid if you have Medicare.

Below is information you may want to consider if you have insurance and are prescribed Dificid.

If you have insurance, your insurance company may require prior authorization before it covers Dificid. This means the company and your doctor will discuss Dificid in regard to your treatment. The insurance company will then determine whether the medication is covered.

If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Dificid requires prior authorization.

Now that you’ve learned about cost and Dificid, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Dificid. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for Dificid.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.