Entresto is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to:

  • decrease the risk of serious heart problems, which can be life threatening, in adults with chronic heart failure
  • treat a type of heart failure called systemic left ventricular systolic dysfunction in children ages 1 year and older

For more information about Entresto’s uses, refer to this article.

Drug details

Here are some details about Entresto:

  • Drug form: oral tablet
  • Generic version: not currently available

The two active drug ingredients in Entresto are sacubitril and valsartan. Sacubitril is a type of drug called a neprilysin inhibitor. Valsartan is a type of drug called an angiotensin II receptor blocker.

Read on to learn about Entresto and cost, as well as how to save money on prescriptions.

As with all medications, the cost of Entresto can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • your location (for example, the cost of Entresto may be different in the United States than in other countries)
  • whether Entresto has a savings program (see the “Financial and insurance assistance” section below)
  • your dose of Entresto (for example, the price of Entresto 49/51 milligrams [mg] may be different from Entresto 97/103 mg)

To find out what the cost of Entresto will be for you, talk with your doctor, pharmacist, or insurance provider.

Note: If you have insurance, your insurance company may require prior authorization before it covers Entresto. This means the company and your doctor will discuss Entresto in regard to your treatment. The insurance company will then determine whether the medication is covered. If a drug requires prior authorization and you start treatment without the prior approval, you could pay the full cost of the medication.

You can ask your insurance company whether Entresto requires prior authorization.

Here are answers to some frequently asked questions about drug cost and Entresto.

Is there a $10 copay card for Entresto?

Yes, the manufacturer offers an Entresto copay savings card, where your copay may be $10 per month. This copay card, which may also be called an Entresto coupon card, can be used if you have commercial or private insurance and you’re taking Entresto. To sign up for the Entresto copay card, visit its website or call 888-368-7378 for more information.

Entresto also has a program where you may be able to receive a 30-day supply of Entresto for free. This program is called a free trial offer and is available to anyone, regardless of insurance. For more information on this offer, visit Entresto’s website or call 888-368-7378.

In addition, if you need help with the cost of Entresto, you may qualify to receive free medication through the manufacturer. This program is called the Novartis Patient Assistance Foundation. For more information on this program, call 800-277-2254 or go to Entresto’s website.

What’s the cost of Entresto with and without insurance?

The cost of Entresto with and without insurance depends on many factors, including your pharmacy, your insurance coverage, and your dose of medication. However, if you don’t have insurance coverage, you may pay more for Entresto than someone who has insurance coverage.

Entresto has a program where you may be able to receive a 30-day supply of Entresto for free. This program is available to anyone, regardless of if you have insurance or not. For more information on this offer, visit Entresto’s website or call 888-368-7378.

If you need additional help paying for your medication, you may qualify to receive free medication through the manufacturer. This program is called the Novartis Patient Assistance Foundation. For more information on this program, call 800-277-2254 or go to the manufacturer’s website.

To find out what your cost of Entresto will be, talk with your doctor or pharmacist.

How can I figure out the cost of Entresto per month?

The best way to figure out the cost of Entresto for you is to talk with your pharmacist. They can determine how much Entresto may cost you per month based on many factors such as your dose and your insurance plan.

If you need help paying for Entresto, see the sections above regarding a copay card and manufacturer assistance programs.

Entresto is only available as a brand-name drug. It doesn’t come in a generic version. A generic drug is an exact copy of the active drug in a brand-name medication.

Generics tend to cost less than brand-name drugs.

Why are costs different for brand-name drugs vs. generic drugs?

Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions. This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

If you take Entresto long term, you may be able to lower its cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of Entresto. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

Using a mail-order pharmacy

Entresto may be available through a mail-order pharmacy. Using this type of service may help lower the drug’s cost and allow you to receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug via mail order.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need financial support to pay for Entresto, or if you need help understanding your insurance coverage, help is available. For example:

  • A program called the Enspire Program is available for Entresto. For more information and to find out if you’re eligible for support, call 888-368-7378 or visit the program website. In addition, a 30-day free trial program and a manufacturer assistance program are available. For more information, see the “Frequently Asked Questions” section above.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Now that you’ve learned about cost and Entresto, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Entresto. However, if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for Entresto.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.