Firazyr (icatibant) is a brand-name liquid for injection prescribed for acute attacks of hereditary angioedema in adults. Its cost with and without insurance can depend on several factors, such as whether it has a savings program.

As with all medications, the cost of Firazyr can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • whether Firazyr has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Firazyr will be for you, talk with your doctor, pharmacist, or insurance provider. If you’d like other information about Firazyr, refer to this article.

The active ingredient of Firazyr is icatibant. It’s available as the generic drug icatibant. A generic drug is considered to be as safe and effective as the original drug. And generics tend to cost less than brand-name drugs.

If your doctor has prescribed Firazyr and you’re interested in using the icatibant injection generic instead, talk with your doctor. They may have a preference for one version or the other. You’ll also need to check with your insurance provider, as it may only cover one or the other.

To find out the cost of icatibant injections compared with the cost of Firazyr, talk with your doctor, pharmacist, or insurance provider.


Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions.

This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

If you take Firazyr long term, you may be able to lower its cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of Firazyr. If your insurance company approves this, it could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

If you need financial support to pay for Firazyr, or if you need help understanding your insurance coverage, help is available. For example:

  • A program called OnePath is available for Firazyr. To learn more and determine whether you’re eligible for support, call 1-866-888-0660 or visit the program website.
  • If you’re interested in a Firazyr copay program or want to inquire about the availability of Firazyr copay cards, you can find additional information on the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Here are answers to some frequently asked questions about drug cost and Firazyr.

How does the cost of Firazyr compare with the cost of Takhzyro, Haegarda, or Orladeyo?

The price you would pay for Firazyr versus that of lanadelumab-flyo (Takhzyro), C1 esterase inhibitor for subcutaneous injection (Haegarda), or berotralstat (Orladeyo) depends on various factors.

For instance, the drug’s form may affect its price. Firazyr, Takhzyro, and Haegarda are all subcutaneous injections, whereas Orladeyo is an oral capsule. Oral capsules are typically less expensive than injections.

There are additional factors that can affect your prescription cost, including:

  • the length of your treatment
  • how often you administer or take your dose
  • whether there are payment assistance programs for your prescribed treatment
  • whether you’re paying out of pocket or have insurance

To learn more about the cost of Firazyr compared with other treatments for your condition, talk with your doctor, pharmacist, or insurance provider.

How much does Firazyr cost with insurance vs. without it?

The cost of Firazyr if you have insurance compared with the cost without it depends on several factors.

Factors that could affect what you pay for this drug without insurance include:

  • whether you apply and qualify for any available savings programs
  • your dosage and treatment plan
  • the pharmacy you use

These same factors may affect the price of Firazyr if you have insurance. But the price you pay with insurance will also depend on:

  • your specific plan benefits
  • any prior authorization requirements you have for drug coverage

To learn more about what you’d pay for Firazyr with or without insurance, talk with your doctor, pharmacist, or insurance provider (if you have one).

Below is information you may want to consider if you have insurance and receive Firazyr.

If you have insurance, your insurance company may require prior authorization before it covers Firazyr. This means the company and your doctor will discuss Firazyr in regard to your treatment. The insurance company will then determine whether the medication is covered.

If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Firazyr requires prior authorization.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.