Humira (adalimumab) is a prescription brand-name medication. It’s approved by the Food and Drug Administration (FDA) to treat moderate to severe chronic (long-term) plaque psoriasis in certain adults.

With plaque psoriasis, your immune system mistakenly attacks your body’s skin cells. This causes your body to rapidly make new skin cells. These cells pile up on the surface of your skin, forming scaly patches called plaques.

Here are the basics on Humira:

Read on for more information on Humira and its use in treating plaque psoriasis. You can also refer to this article for a comprehensive look at Humira and its other uses.

* The FDA has approved biosimilar forms of adalimumab, but it isn’t known when they’ll become available to the public for use.

To treat plaque psoriasis, your first dose of Humira will likely be given at your doctor’s office. Humira is given as a subcutaneous injection. The first dose is typically one 80-milligram (mg) injection. A healthcare professional may show you how to give yourself injections at home.

One week after your first dose, you’ll likely start a dosage of 40 mg every other week.

Your doctor may adjust your dosage based on certain factors, including your age and other medical conditions you have. It’s important to take the dosage your doctor prescribes for you.

Note: In addition to treating plaque psoriasis, Humira has other uses. Keep in mind that the drug’s dosage may differ with these other uses. To learn more, you can see this article or talk with your doctor.

Humira is a liquid solution that’s injected subcutaneously. You’ll most likely get your first Humira injection at your doctor’s office. You may be able to give yourself Humira injections at home, after your doctor shows you the proper technique.

How to use

Humira injections can be given into your thigh or abdomen (belly). You should use a different spot each time. It’s best to avoid any areas where your skin is bruised or tender.

You’ll inject the drug using a prefilled pen or a prefilled syringe. You can view video instructions about how to inject Humira on the manufacturer’s website.

How often to use

Humira is typically given every other week. If you miss a dose of Humira, you should inject it as soon as possible or reschedule your appointment.

If you have any questions about using Humira, talk with your doctor or pharmacist.

Below are answers to some commonly asked questions about Humira for plaque psoriasis.

How long does it take for Humira to work for plaque psoriasis?

It can vary. Some people notice Humira working as soon as 2 weeks after starting treatment. But some people take Humira for 4 months or longer before they notice significantly clearer skin.

If you’re not seeing any improvement in your symptoms after a few months of Humira treatment, talk with your doctor. They can recommend if you should continue with Humira treatment.

How does Humira compare to Enbrel?

Humira (adalimumab) and Enbrel (etanercept) are very similar drugs. But how people respond to either drug can vary.

Both medications belong to the same class of drugs,* called tumor necrosis factor (TNF) blockers. They’re both approved to treat plaque psoriasis, and both are given by subcutaneous injection. Humira is injected every other week. Enbrel is injected once per week.

Humira and Enbrel can cause many of the same side effects. In a clinical study that compared the two drugs, Humira was shown to cause worse injection site side effects than Enbrel. These effects included stinging and burning at the injection site.

However, a newer formulation of Humira may cause injection site reactions less often. It’s called Humira Citrate-free. You and your doctor can discuss your treatment options and decide which drug is best for you.

* A drug class is a group of medications that work in a similar way.

How long do people take Humira for plaque psoriasis?

In clinical trials, Humira was used to treat plaque psoriasis for up to 12 months. If you and your doctor decide that Humira is an effective treatment, and you don’t develop any serious or bothersome side effects, it’s likely that you’ll continue taking it long term.

If you have questions about how long you’ll need to take Humira, talk with your doctor.

Can Humira cause plaque psoriasis?

No. Humira has been shown in clinical studies to be an effective treatment for moderate to severe plaque psoriasis in adults. It isn’t known to cause plaque psoriasis or make it worse.

The cause of plaque psoriasis isn’t fully understood, but it may be related to genetics and your immune system. Your doctor can provide more information.

The use of Humira for plaque psoriasis* may cause side effects that are mild or serious. The lists below include some of the main side effects that have been reported with Humira use. For information on other potential side effects of the drug, talk with your doctor or pharmacist. You can also see our article on Humira side effects or refer to Humira’s medication guide.

Note: After the Food and Drug Administration (FDA) approves a medication, it tracks and reviews side effects of the drug. If you develop a side effect while taking Humira and would like to inform the FDA, visit MedWatch.

* Humira is also used to treat other conditions. The side effects for other conditions are similar to those for plaque psoriasis.

Mild side effects

Humira may cause mild side effects in some people. These side effects may be temporary, lasting a few days or weeks. But if they last longer, or if they bother you or become severe, it’s important to talk with your doctor or pharmacist.

More common but mild side effects of Humira can include:

  • infections, such as colds or sinus infections
  • skin reactions at the injection site, such as reddening or discoloration, bleeding, or pain
  • headache
  • rash

Serious side effects

Serious side effects can occur with Humira treatment. Call your doctor right away if you develop serious side effects while using Humira. If the side effects seem life threatening or you think you’re having a medical emergency, call 911 or your local emergency number immediately.

Less common but serious side effects of Humira may include:

* Humira has a boxed warning for this side effect. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Before using Humira” section below.

With plaque psoriasis, your immune system attacks your body’s skin cells. This causes your body to rapidly make new skin cells. These cells pile up on the surface of the skin, forming discolored, scaly patches called plaques. Plaques most commonly appear on the elbows, knees, scalp, and lower back.

Why plaque psoriasis happens isn’t fully known, but your immune system and genetics are involved. It’s typically a lifelong condition, and the symptoms usually come and go.

Triggers can cause symptoms to flare up (suddenly get worse). Triggers may include stress, infections, cold weather, skin injuries, or certain drugs.

Symptoms of plaque psoriasis

In addition to plaques (which may appear red or silvery), symptoms may include:

  • intense itchiness
  • feeling like your skin is burning, tight, or painful

Who Humira is prescribed for

Humira is not for everyone with plaque psoriasis. Your doctor may suggest it as a treatment for you if:

  • you’re an adult with chronic (long-term) plaque psoriasis, and
  • your plaque psoriasis is moderate to severe, and
  • you’re eligible for phototherapy (light therapy) or systemic therapy (medications that work throughout your entire body) to treat plaque psoriasis, and
  • your plaque psoriasis would benefit more from Humira than it would from other systemic therapies, or
  • you cannot use other systemic therapies

Your doctor can give you more information about phototherapy and other systemic therapies. They’ll guide you on which treatments are likely to work best for you.

Humira works to treat plaque psoriasis by decreasing certain actions in your immune system.

The way Humira works

Humira blocks a protein called tumor necrosis factor (TNF). In a healthy immune system, TNF helps the body fight off infections. TNF functions by triggering an inflammatory reaction in response to a germ, such as a virus.

But in people with plaque psoriasis (or other autoimmune diseases), high levels of TNF can build up in the blood. This causes excessive inflammation, which causes symptoms to flare up (suddenly get worse).

Humira blocks TNF from causing an inflammatory reaction. This can lead to fewer flare-ups and less severe skin plaques.

Clinical studies have shown that Humira is an effective treatment for moderate to severe plaque psoriasis in certain adults.

Current treatment guidelines recommend adalimumab as monotherapy (single-drug treatment) for plaque psoriasis in adults. Adalimumab is the active drug in Humira.

If you’re wondering whether Humira may be effective for your plaque psoriasis, talk with your doctor.

Before you use Humira, there’s some important information to keep in mind. The drug may not be a safe option for you if you have certain medical conditions or other factors that affect your health. Some of these are mentioned below.

Boxed warnings

This drug has boxed warnings. These are the most serious warnings from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous.

Risk of serious infections. Taking Humira can increase your risk for severe infections. These infections may lead to a hospital stay or, in rare cases, death. They include sepsis (a type of blood infection), tuberculosis (TB), and histoplasmosis (a fungal infection that’s similar to pneumonia).

During Humira treatment, your doctor will monitor you for infection symptoms. If you develop a serious infection, they’ll likely have you stop taking the drug.

Your doctor will also test you for certain infections, such as TB, before you start treatment. If you have an infection, they’ll treat you for it before starting Humira.

Cancer risk. Taking Humira may increase your risk for developing cancer. Cancers, including lymphomas (cancers that affect white blood cells), have occurred in people who took Humira, including children. In some cases, these cancers led to death.

A rare type of lymphoma, hepatosplenic T-cell lymphoma, has been reported mainly in adolescent and young adult males who had inflammatory bowel disease (IBD). Their IBD may have included Crohn’s disease or ulcerative colitis. (Humira is also used to treat these conditions.)

Other warnings

In addition to boxed warnings, Humira has other warnings.

If any of the following medical conditions or other health factors are relevant to you, talk with your doctor before using Humira:

  • if you currently have an infection
  • if you have cancer
  • if you have or have had problems with your liver, heart, or nerves
  • if you have or have had hepatitis B
  • if you’re pregnant or thinking of becoming pregnant
  • if you’re breastfeeding or planning to breastfeed
  • if you’ve had an allergic reaction to Humira, rubber, latex, or any of Humira’s other ingredients

How much Humira costs is based on several factors. These can include your prescribed treatment plan, your insurance coverage, the pharmacy you use, and your location. If you receive Humira injections from a healthcare professional, the price is also based on the cost of the appointment. For estimates of how much Humira pens (or other forms) cost, see GoodRx.com.

Humira is a brand-name biologic medication. The FDA has approved biosimilar versions of the drug, but it’s not known when they’ll become available for use. Biologic drugs usually cost more than biosimilar versions. To learn more, talk with your doctor or pharmacist.

Now that you’ve learned about Humira for plaque psoriasis, you may still have some questions. Talk with your doctor or pharmacist, who can advise you on whether Humira might be right for you.

Here are some other helpful references:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.