Kynmobi (apomorphine)

What is Kynmobi?

Kynmobi is a brand-name prescription medication. It’s FDA-approved to treat off episodes in adults with Parkinson’s disease (PD).

PD is a movement disorder that affects your nervous system. An off episode refers to a period of time in which your PD symptoms get worse. Kynmobi is an acute (short-term) treatment that’s used as needed.

Drug details

The active drug in Kynmobi is apomorphine. Apomorphine belongs to a class of medications known as dopamine agonists. A medication class is a group of drugs that work in a similar way.

Kynmobi comes as a sublingual film (a film that you place under your tongue). The film dissolves in about 3 minutes and releases the medication. Kynmobi comes in the following strengths:

• 10 milligrams (mg)
• 15 mg
• 20 mg
• 25 mg
• 30 mg

Effectiveness

For information about the effectiveness of Kynmobi, see the “Kynmobi uses” section below.

Kynmobi generic

Kynmobi is available only as a brand-name medication. It’s not currently available in generic form.

A generic drug is an exact copy of the active drug in a brand-name medication. Generics usually cost less than brand-name drugs.

Kynmobi cost

As with all medications, the cost of Kynmobi can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

It’s important to note that you’ll have to get Kynmobi at a specialty pharmacy. This type of pharmacy is authorized to carry specialty medications. These are drugs that may be expensive or may require help from healthcare professionals to be used safely and effectively.

Before approving coverage for Kynmobi, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered.

If you’re not sure if you’ll need to get prior authorization for Kynmobi, contact your insurance company.

Financial and insurance assistance

If you need financial support to pay for Kynmobi, or if you need help understanding your insurance coverage, help is available.

Sunovion Pharmaceuticals Inc., the manufacturer of Kynmobi, offers a program called Kynmobi Kynnect. Through this program, you can find information about copay assistance, insurance coverage, and more.

For more information and to find out if you’re eligible for support, call 844-KYNMOBI (844-596-6624) or visit the program website.

Generic version

Kynmobi isn’t available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs.

Kynmobi side effects

Kynmobi can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Kynmobi. These lists do not include all possible side effects.

For more information about the possible side effects of Kynmobi, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be concerning or bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Kynmobi, you can do so through MedWatch.

Mild side effects

Mild side effects* of Kynmobi can include:

• mild dizziness
• nausea
• pain or swelling in your mouth
• mild sleepiness†

Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

* This is a partial list of mild side effects from Kynmobi. To learn about other mild side effects, talk with your doctor or pharmacist, or view Kynmobi’s patient information.
† For more information about this side effect, see “Side effect details” below.

Serious side effects

Serious side effects from Kynmobi aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

• New or uncontrollable strong urges. Symptoms can include:
  • gambling
  • compulsive shopping
  • increased sexual urges
• High fever and confusion when your Kynmobi dosage is changed or when you stop taking Kynmobi. Symptoms can include:
  • changes in your breathing and heart rhythm
  • confusion
  • stiff muscles
  • very high fever
• Heart problems, including changes in your heart rhythm such as long QT syndrome. Symptoms can include:
  • chest pain
  • fast heart rate
  • feeling faint
  • shortness of breath
• Nausea and vomiting.*
• Severe sleepiness.*
• Low blood pressure.*
• Allergic reaction.*
• Sores or bleeding in your mouth, gums, tongue, or lips.†
• Priapism (prolonged, painful erection).‡

* For more information about this side effect, see “Side effect details” below.
† Your doctor will likely have you stop taking Kynmobi if this side effect occurs.
‡ If you experience priapism, get medical help immediately. Call your doctor or go to the nearest emergency room.

Side effect details

Here’s some detail on certain side effects this drug may cause.

Nausea and vomiting

It’s possible to have nausea and vomiting as a side effect of Kynmobi.

Nausea was the most common side effect reported in a clinical study of Kynmobi. Vomiting also occurred, but it was less common than nausea. A few people in the study stopped taking Kynmobi due to nausea or vomiting.

It’s typically recommended that you start taking an antiemetic drug (a type of drug that helps prevent nausea and vomiting) 3 days before you start taking Kynmobi. You’ll take the antiemetic only for as long as needed to manage your nausea and vomiting. See the “Kynmobi use with other drugs” section below for details.

If you experience nausea or vomiting while taking Kynmobi, talk with your doctor. They may recommend an antiemetic such as trimethobenzamide (Tigan) to help treat this side effect. If your nausea or vomiting is severe or interfering with your daily life, your doctor may recommend stopping Kynmobi.

Sleepiness

Sleepiness is a potential side effect of Kynmobi. Mild sleepiness was one of the more common side effects reported by people who took the drug in a clinical study.

Kynmobi can also cause serious daytime sleepiness. In some cases, people taking Kynmobi have fallen asleep during daily activities, including while driving a car. While some people “sensed” when this was about to happen, other people reported feeling alert just before falling asleep in the middle of an activity.

Before you start taking Kynmobi, you and doctor will discuss your risks for sleepiness. You should avoid driving a car, operating machinery, and engaging in other potentially dangerous activities until you know how Kynmobi affects you.

If Kynmobi causes daytime sleepiness that interferes with your daily activities, your doctor will likely recommend that you stop taking the medication. If there aren’t any other treatment options, your doctor may have you continue taking Kynmobi while avoiding driving and engaging in other potentially dangerous activities.

Low blood pressure

It’s possible to experience low blood pressure as a side effect of Kynmobi. Low blood pressure may also be called hypotension. Although not common, this side effect was reported by people taking the drug in a clinical study.

Low blood pressure caused by Kynmobi is typically mild, and it usually doesn’t cause noticeable symptoms. In rare cases, this side effect may be severe, and some people may experience severe orthostatic hypotension. This is low blood pressure that occurs when getting up from a sitting or lying position. This may occur with other symptoms, such as:

• nausea
• sweating
• dizziness
• fainting

Sometimes these side effects can cause you to fall, which can be serious.

You and your doctor should review your risks for low blood pressure before you begin taking Kynmobi. Certain conditions (such as heart disease) and certain medications (such as drugs for high blood pressure) can increase your risk for this side effect. For more information, see the “Kynmobi interactions” section below.

You should also avoid drinking alcohol while taking Kynmobi, since doing so can increase your risk for low blood pressure. For more information, see the “Kynmobi and alcohol” section below.

If you experience low blood pressure, fainting, or falls while taking Kynmobi, talk with your doctor. They can review your health history to see if there are other factors that could be causing your symptoms. If they determine that Kynmobi is the likely cause of your symptoms, they’ll probably suggest stopping the medication and discussing other treatment options.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Kynmobi.

Symptoms of a mild allergic reaction can include:

• skin rash
• itchiness
• flushing (temporary warmth, redness, or deepening of skin color)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your tongue, mouth, or throat
• trouble breathing

Call your doctor right away if you have an allergic reaction to Kynmobi, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Kynmobi dosage

The Kynmobi dosage your doctor prescribes will depend on several factors. These include:

• the type and severity of the symptoms you’re using Kynmobi to treat
• how your body responds to Kynmobi, such as any side effects that you experience
• other medical conditions you may have

Typically, your doctor will start you on a low dosage. Then, they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Kynmobi comes as a sublingual film, which you place under your tongue. The film dissolves in about 3 minutes and releases the medication. The drug comes in the following strengths:

• 10 milligrams (mg)
• 15 mg
• 20 mg
• 25 mg
• 30 mg

Dosage for off episodes of Parkinson’s disease

The recommended starting dosage of Kynmobi is 10 mg, taken as needed when symptoms of an off episode start. An off episode refers to a period of time in which your Parkinson’s disease (PD) symptoms get worse.

Your first dose should be taken at your doctor’s office or clinic while you’re experiencing an off episode. This is done so that your doctor can monitor your heart rate and blood pressure after your first dose. Your doctor may recommend not taking any other medications you use to treat your PD before your first dose. This is to ensure that you’re experiencing an off episode.

After your first dose, you’ll use Kynmobi only as needed. If the first 10-mg dose works well for treating your off episodes, your doctor will recommend that you continue to use this dosage as needed. If 10 mg doesn’t reduce your symptoms, your doctor may increase your dose in amounts of 5 mg, as needed.

You should not take more than 5 doses of Kynmobi in 24 hours. Doses should be separated by at least 2 hours.

Note: Kynmobi is often prescribed with a drug to treat or prevent nausea and vomiting, which are possible side effects of Kynmobi. For more information, see the “Kynmobi use with other drugs” section below.

What if I miss a dose?

Kynmobi is only used as needed, so you don’t need to worry about missing a dose. Take Kynmobi when you start to experience off episode symptoms, according to your doctor’s instructions.

Will I need to use this drug long term?

Kynmobi is meant to be used as a long-term treatment. If you and your doctor determine that the drug is safe and effective for you, you’ll likely take it long term.

Kynmobi uses

The Food and Drug Administration (FDA) approves prescription drugs such as Kynmobi to treat certain conditions.

Kynmobi for off episodes of Parkinson’s disease

Kynmobi is approved to treat off episodes in adults with Parkinson’s disease (PD). PD is a movement disorder that affects your nervous system. Symptoms can include:

• tremors (uncontrolled shaking), especially in one hand or foot
• trouble moving and speaking
• loss of balance

PD is a progressive condition, which means it gets worse over time. Many people with PD find that their medications may not work as well as their condition gets worse. For example, your everyday PD treatment may reduce your symptoms, but relief from symptoms may not last as long as it used to. This can lead to off episodes, which are periods of time in which symptoms return or get worse. This can happen between doses of PD medications.

Symptoms of PD may be caused by low dopamine levels in your brain. Dopamine is a brain chemical that helps your body control coordination and movement.

Kynmobi is an acute (short-term) treatment that’s used as needed to treat off episodes. It isn’t fully understood how Kynmobi works. It’s thought to be related to how the drug increases the amount of dopamine in certain parts of your brain. See the “How Kynmobi works” section below for more details.

Effectiveness for off episodes of Parkinson’s disease

Kynmobi has been shown to be effective for treating symptoms of off episodes. For more information about how the drug performed in clinical studies, see its prescribing information.

Kynmobi and children

Kynmobi isn’t approved for use in children under 18 years old. This is because the drug hasn’t been studied in children.

Kynmobi use with other drugs

Kynmobi is used as needed to treat off episodes* in adults with Parkinson’s disease (PD). This means while you’re using Kynmobi, you’ll continue taking other drugs you may take to treat PD, such as carbidopa/levodopa (Sinemet).

Also, Kynmobi is typically prescribed with an antiemetic drug. This type of drug helps treat or prevent nausea and vomiting. These are possible side effects of Kynmobi. The drug trimethobenzamide (Tigan) is usually recommended. In fact, this is the only antiemetic that’s been studied with Kynmobi.

It’s very important that you only use the antiemetic drug your doctor prescribes while you’re using Kynmobi. This is because some antiemetics can interact with Kynmobi and increase your risk for serious side effects. For more information, see the “Kynmobi interactions” section below.

You’ll typically start an antiemetic drug 3 days before you start Kynmobi treatment. You’ll take it only for as long as you and your doctor decide is necessary to control nausea and vomiting. In general, 2 months is the longest recommended amount of time for taking an antiemetic drug with Kynmobi.

If you have questions about Kynmobi use with other drugs, talk with your doctor or pharmacist.

* An off episode refers to a period of time in which your PD symptoms get worse.

Kynmobi and alcohol

You should avoid drinking alcohol after using Kynmobi. Drinking alcohol can increase your risk for serious side effects from Kynmobi, including severe low blood pressure and sleepiness. Sleepiness can lead to falling asleep during an activity, such as driving. (See the “Kynmobi side effects” section above for details.)

Be sure to tell your doctor if you drink alcohol before you begin taking Kynmobi. They’ll want to discuss the risks of drinking alcohol while taking Kynmobi.

Kynmobi interactions

Kynmobi can interact with several other medications.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Kynmobi and other medications

Below is a list of medications that can interact with Kynmobi. This list does not contain all drugs that may interact with Kynmobi.

Before taking Kynmobi, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Types of medications that can interact with Kynmobi include:

• A group of medications called 5HT3 antagonists. These drugs shouldn’t be taken while you’re using Kynmobi. 5HT3 antagonist drugs are antiemetics (a type of drug used to treat or prevent nausea and vomiting). Taking this type of drug with Kynmobi can increase your risk for low blood pressure and fainting. Some people taking a 5HT3 antagonist with apomorphine, the active drug in Kynmobi, have “blacked out” or lost consciousness due to taking these drugs together. Examples of these drugs include:
  • ondansetron (Zofran)
  • alosetron (Lotronex)
  • granisetron (Sancuso, Sustol)
  • palonosetron (Akynzeo, Aloxi)
• Nitroglycerin. Nitroglycerin is used to relieve chest pain in people with certain heart conditions. This drug may increase your risk for low blood pressure and fainting if taken with Kynmobi. If you need to take sublingual nitroglycerin while using Kynmobi, you should lie down before and after taking the nitroglycerin. Sublingual means the medication is taken by placing it under your tongue.
• Blood pressure medications. Antihypertensives (medications that lower your blood pressure) can interact with Kynmobi and increase your risk for low blood pressure as a side effect. Examples of antihypertensives include:
  • angiotensin converting enzyme (ACE) inhibitors, such as lisinopril (Prinivil, Zestril)
  • angiotensin receptor blockers (ARBs), such as valsartan (Diovan)
  • diuretics (also called “water pills”), such as hydrochlorothiazide
  • calcium channel blockers, such as amlodipine (Norvasc)
• Dopamine antagonists. Kynmobi belongs to a group of drugs called dopamine agonists. Medications that are dopamine antagonists work in the opposite way. So, taking a dopamine antagonist with Kynmobi could cause Kynmobi to not work as well, or not work at all. Examples of dopamine antagonists include:
  • metoclopramide (Reglan)
  • prochlorperazine
  • haloperidol (Haldol)
• Medications that affect the QT interval. Although rare, Kynmobi may affect part of your heart rhythm called the QT interval. Using Kynmobi with other medications that can also cause this side effect could increase your risk. Other medications that can affect the QT interval include:
  • amiodarone (Pacerone)
  • amitriptyline
  • flecainide
  • haloperidol (Haldol)
  • quetiapine (Seroquel)

Kynmobi and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Kynmobi. However, you should still check with your doctor or pharmacist before using any of these products while taking Kynmobi.

Kynmobi and foods

There aren’t any foods that have been specifically reported to interact with Kynmobi. If you have any questions about eating certain foods with Kynmobi, talk with your doctor.

How to take Kynmobi

You should take Kynmobi according to your doctor’s or healthcare professional’s instructions.

Kynmobi comes as a sublingual film (a film that you place under your tongue). The film dissolves in about 3 minutes and releases the medication.

Before taking your dose, drink water to moisten your mouth. This will help the film dissolve. It’s important to try not to talk or swallow any spit until the film completely dissolves. Talking or swallowing before the film dissolves may affect how well your body absorbs your dose.

After taking a dose, avoid changing your body position quickly. Get up slowly after lying down or sitting. This is because Kynmobi can lower your blood pressure, which could lead to fainting or dizziness.

When to take

Kynmobi is used as needed to treat off episodes in adults with Parkinson’s disease. You should take Kynmobi when you start to experience off episode symptoms, according to your doctor’s instructions. If you take more than one dose, make sure that the doses are separated by at least 2 hours.

Taking Kynmobi with food

You shouldn’t eat or drink while your Kynmobi film is dissolving.

It’s OK to take a dose if you’ve eaten recently, though. And, it’s OK to eat and drink after your film completely dissolves.

Can Kynmobi be crushed, split, or chewed?

No, you shouldn’t crush, split, or chew Kynmobi films. You also shouldn’t swallow them before they dissolve. Kynmobi films must be allowed to completely dissolve under your tongue.

How Kynmobi works

Kynmobi is prescribed to treat off episodes in adults with Parkinson’s disease (PD). PD is a movement disorder that affects your nervous system. Off episodes are periods of time in which your symptoms return or get worse. This can happen between doses of PD medications.

PD symptoms may be caused by low dopamine levels in your brain. Dopamine is a brain chemical that helps your body control coordination and movement.

It isn’t fully understood how Kynmobi works to reduce off episode symptoms. It may work by increasing the amount of dopamine in certain parts of your brain.

How long does it take to work?

Kynmobi starts to work as soon as you take your dose. In a clinical study, people reported improvement in their symptoms 30 minutes after taking a dose of Kynmobi.

If you have other questions about how Kynmobi works, or how long it may take to work, talk with your doctor or pharmacist.

Kynmobi and pregnancy

It isn’t known whether Kynmobi is safe to take during pregnancy. Animal studies showed an increased risk for pregnancy loss and for heart or blood vessel problems in offspring. But animal studies don’t always predict what will happen in people.

If you’re pregnant, or planning to become pregnant, talk with your doctor before you begin taking Kynmobi. They can review the risks and benefits of different treatments for your condition while pregnant.

Kynmobi and birth control

It’s not known if Kynmobi is safe to take during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re using Kynmobi.

For more information about taking Kynmobi during pregnancy, see the “Kynmobi and pregnancy” section above.

Kynmobi and breastfeeding

It isn’t known whether Kynmobi is safe to use while breastfeeding. This is because the drug’s use during breastfeeding hasn’t been studied.

Talk with your doctor about your options for feeding your child while you’re taking Kynmobi. They may recommend different treatments for your condition.

Common questions about Kynmobi

Here are answers to some frequently asked questions about Kynmobi.

If I have a sulfa allergy, can I take Kynmobi?

Yes, it’s safe to take Kynmobi if you have a sulfonamide (sulfa) allergy.

However, people with a sulfite allergy should not take Kynmobi. The drug contains a sulfite, which could cause a severe, life threatening allergic reaction in people with a sulfite allergy.

Having a sulfite allergy is not the same as having a sulfa allergy. For more information on the differences between sulfa and sulfite allergies, you can check out this article.

Will I be able to drive or do other activities after I take Kynmobi?

Maybe, but it depends on how the drug affects you.

You shouldn’t drive or do other potentially dangerous activities until you know how Kynmobi affects you. This is because Kynmobi can cause serious side effects, such as daytime sleepiness or falling asleep during activities. It can also cause low blood pressure, which may lead to dizziness or fainting. These side effects can make certain activities, such as driving or operating machinery, very dangerous.

Also, after taking a dose of Kynmobi, you should avoid changing your body position quickly. Get up slowly after lying down or sitting, in case the drug causes dizziness or other side effects.

Talk with your doctor about your activity level and daily routines before starting Kynmobi. Your doctor can help determine when it’s safe for you to resume certain activities after you start Kynmobi treatment.

How many doses of Kynmobi can I take per day?

The maximum dosage of Kynmobi is five doses per day. The strength of your doses doesn’t affect this maximum dosage.

Remember, Kynmobi is only used as needed, to treat off episodes* of Parkinson’s disease. There may be some days where you don’t need any doses.

If you feel the need to use Kynmobi more than five times per day, talk with your doctor. They may want to discuss how well Kynmobi is working to reduce your symptoms, and whether other treatment options may work better for you.

* An off episode refers to a period of time in which your Parkinson’s disease symptoms get worse.

Kynmobi precautions

Before taking Kynmobi, talk with your doctor about your health history. Kynmobi may not be right for you if you have certain medical conditions or other factors affecting your health. These include:

• Liver problems. Your liver helps your body clear drugs such as Kynmobi from your system. Kynmobi is usually safe for people with mild or moderate liver problems. But if you have liver problems, your doctor may want to monitor you more closely than usual, especially when you first begin taking Kynmobi. People with severe liver problems should not take Kynmobi. Your doctor can help determine the severity of any liver problems you have, and whether Kynmobi is safe for you to use.
• Kidney problems. Your body gets rid of drugs such as Kynmobi through certain organs, including your kidneys. Kynmobi is usually safe for people with mild or moderate kidney problems. Your doctor may want to monitor you more closely than usual, however, especially when you first start taking the drug. You shouldn’t use Kynmobi if you have severe kidney problems, such as end-stage kidney disease. Your doctor can help determine the severity of any kidney problems you have, and whether Kynmobi is safe for you.
• Heart problems. Kynmobi can cause some heart-related side effects, such as long QT syndrome. People who already have heart problems may be at higher risk for these side effects. Be sure to tell your doctor about any heart problems you have, or have had in the past, before you start using Kynmobi.
• Low blood pressure. Kynmobi can cause low blood pressure. You may be at higher risk if you already have low blood pressure. And, your risks for other side effects, such dizziness or fainting, may be increased as well. Talk with your doctor about your blood pressure before you begin treatment with Kynmobi.
• Dizziness or fainting spells. Low blood pressure is a possible side effect of Kynmobi, which can increase your risk for dizziness or fainting. You may be at higher risk if you already have problems with dizziness or fainting. Talk with your doctor about any conditions you have that may cause dizziness or fainting before you begin treatment with Kynmobi.
• Trouble staying awake during the day. Kynmobi may cause you to feel sleepy during the day time. Some people taking Kynmobi have abruptly fallen asleep during the day, including while doing activities such as driving. If you already struggle to stay awake during the day, Kynmobi may make this worse. Talk with your doctor about whether Kynmobi is right for you.
• Alcohol use. You should avoid drinking alcohol after using Kynmobi. Drinking alcohol can increase your risk for serious side effects (see “Kynmobi and alcohol” above for details). Be sure to tell your doctor if you drink alcohol before you begin taking Kynmobi.
• Mental health conditions. Although not common, some people have reported side effects such as hallucinations, confusion, and disorientation while using Kynmobi. People with a mental health condition may be at higher risk for these side effects. Depending on the condition you have, Kynmobi may not be safe for you. Be sure to discuss your mental health with your doctor before you begin using Kynmobi.
• Allergic reaction or allergy to sulfites. If you’ve had an allergic reaction to Kynmobi or any of its ingredients, you shouldn’t use Kynmobi. This includes people with a sulfite allergy, as Kynmobi contains a sulfite called sodium metabisulfite. This is not the same as having a sulfa allergy (see “Common questions about Kynmobi” above for details). Ask your doctor what other medications could be better options for you.
• Pregnancy. It’s not known whether Kynmobi is safe to use while pregnant. For more information, see the “Kynmobi and pregnancy” section above.
• Breastfeeding. It isn’t known whether it’s safe to use Kynmobi while breastfeeding. For more information, see the “Kynmobi and breastfeeding” section above.

Note: For more information about the potential negative effects of Kynmobi, see the “Kynmobi side effects” section above.

Kynmobi overdose

Do not use more Kynmobi than your doctor recommends. For some drugs, doing so may lead to unwanted side effects or overdose.

What to do in case you take too much Kynmobi

If you think you’ve taken too much of this drug, call your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. If your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.

Kynmobi withdrawal and dependence

Kynmobi is approved to treat off episodes* in adults with Parkinson’s disease (PD).

Rarely, people taking drugs for PD have experienced high fever and confusion when their dose is changed or when they stop taking the medication. It’s thought that this could occur with Kynmobi as well, but this wasn’t reported during clinical studies of the drug. You shouldn’t stop taking Kynmobi, or change your dose, unless your doctor instructs you to do so.

There haven’t been studies on whether Kynmobi can cause drug dependence. With dependence, your body relies on a drug to feel normal. It’s important to note that, very rarely, there have been reports of people misusing† medications that contain apomorphine (the active drug in Kynmobi). If you have concerns about misuse while taking Kynmobi, talk with your doctor.

* An off episode refers to a period of time in which your Parkinson’s disease symptoms get worse.
† Misusing a drug means using it in a way other than how it’s prescribed.