Mydayis (mixed amphetamine salts) is a brand-name oral capsule prescribed for ADHD in adults and children ages 13 years and older. As with other drugs, Mydayis can cause side effects, such as insomnia, dry mouth, and decreased appetite.

Mydayis has a boxed warning. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section.

Mydayis can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took Mydayis in clinical trials:

Mild side effects can occur with Mydayis use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to Mydayis’s prescribing information.

Mild side effects that people taking Mydayis have reported include:

These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect while taking Mydayis and want to tell the FDA about it, visit MedWatch.

Although not common, Mydayis may cause serious side effects. The list below may not include all possible serious side effects of the drug. For more information, you can refer to Mydayis’s prescribing information.

If you develop serious side effects while taking Mydayis, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects and their symptoms that people taking Mydayis have reported include:

  • circulation problems, such as Raynaud’s disease, which may include symptoms such as:
    • fingers or toes that turn white or paler than usual
    • tingling or pain in the fingers or toes
  • seizures, which may include symptoms such as:
    • loss of consciousness or awareness
    • muscle jerking or shaking, typically affecting both sides of the body
    • facial twitching
    • staring into space
  • new or worsening psychosis (loss of touch with reality) or mania (extreme mood or behavior changes), which may include symptoms such as:
    • extreme high energy
    • seeing or hearing things that aren’t real
    • racing thoughts
  • depression, which may include symptoms such as:
    • loss of interest in hobbies or activities you used to enjoy
    • changes in appetite or sleep
    • fatigue
    • difficultly concentrating
    • thoughts of suicide or dying
  • tics (uncontrollable movements)
  • risk of misuse and dependence*
  • cardiovascular effects*

* For more information about this side effect, see “Side effect specifics.”

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

  • Ask the tough question: “Are you considering suicide?”
  • Listen to the person without judgment.
  • Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
  • Stay with the person until professional help arrives.
  • Try to remove any weapons, medications, or other potentially harmful objects if it’s safe to do so.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Find more links and local resources.

Mydayis may cause several side effects. Here are some frequently asked questions about the drug’s side effects and their answers.

How do side effects of Mydayis compare with those seen with Adderall or Vyvanse?

Mydayis, amphetamine/dextroamphetamine (Adderall), and lisdexamfetamine (Vyvanse) are all drugs prescribed to treat ADHD. They belong to a class of drugs called central nervous system (CNS) stimulants. These drugs share many side effects that may include:

  • insomnia
  • decreased appetite
  • feeling anxious or jittery
  • dry mouth
  • weight loss

Serious side effects that can occur with Mydayis, Adderall, and Vyvanse may include:

Talk with your doctor or pharmacist if you have any questions about how the side effects of Mydayis, Adderall, and Vyvanse compare.

* For more information about this side effect, see “Side effect specifics.”

Does Mydayis cause long-term side effects?

Long-term side effects of Mydayis were not reported in its clinical trials. However, clinical trials with Mydayis were short-term and only lasted 4 to 7 weeks. Some long-term side effects have been reported with Mydayis after it was approved for use. These include:

Long-term side effects include those that start at any time during treatment, even if you’ve been taking it for a long time. It also includes those that don’t go away, even if you stop taking Mydayis.

If you have questions about possible long-term side effects that can occur with Mydayis, talk with your doctor.

* For more information about this side effect, see “Side effect specifics.”

How do side effects of Mydayis in children compare with side effects seen in adults?

Mydayis is approved for attention deficit hyperactivity disorder (ADHD) in adults and children ages 13 years and older. The side effects in children were similar to those in adults in the drug’s clinical trials. However, children may be more likely to experience dizziness, nausea, and abdominal pain than adults.

There have also been reports of weight loss and slowed growth in children taking stimulant medications, such as Mydayis. This may result in a lower weight and shorter height than other children of the same age. Your child’s doctor will closely watch your child’s height and weight while they take Mydayis. If they see signs that your child’s growth is affected, they may recommend temporarily stopping treatment with Mydayis.

If you have questions about the side effects of Mydayis in children, talk with your child’s doctor or a pharmacist.

Learn more about some of the side effects that Mydayis may cause. To find out how often side effects occurred in clinical trials, see the prescribing information for Mydayis.

Risk of misuse or dependence

Mydayis has a boxed warning for the risk of misuse and dependence, which can result in overdose and death. Mydayis is a controlled substance. This means there are strict rules and regulations for prescribing and dispensing Mydayis due to its risk of misuse and dependence.

Misuse refers to using a drug other than how your doctor has prescribed it. This includes taking a higher dose or taking it more often than prescribed. Misuse can increase your risk of serious side effects and lead to substance use disorder and dependence on the drug. Dependence means your body needs the drug for it to function as usual.

Misuse of Mydayis can cause the following symptoms:

  • high blood pressure
  • high heart rate
  • anxiety
  • feeling jittery or restless
  • agitation
  • aggressive behavior
  • seeing or hearing things that aren’t real

What you can do

Your doctor will discuss the risks and benefits of Mydayis treatment with you before prescribing it. Be sure to tell your doctor if you have ever had a substance use disorder involving medications or alcohol. They may monitor you more closely during treatment or recommend a different medication for your condition.

Be sure to take Mydaysis exactly as your doctor has prescribed. Don’t change your Mydaysis dose or how often you take it without talking with your doctor first. Mydayis shouldn’t be shared with anyone, even if they have symptoms similar to yours.

Talk with your doctor or pharmacist if you have concerns or questions about the risks of misuse or dependence while taking Mydayis.

Cardiovascular effects

Mydayis can cause side effects that involve the cardiovascular system (heart and blood vessels). Some people may have increased blood pressure or heart rate while taking Mydayis. It can also cause heart palpitations (a feeling of extra or skipped beats). These were common side effects reported in clinical trials of Mydayis. There have also been reports of serious life threatening heart problems, such as sudden death, heart attack, or stroke. But these were rare.

People with a heart problem, such as arrhythmia or coronary artery disease, or with a heart defect may have an increased risk of serious side effects with Mydayis.

What you can do

Before starting Mydayis treatment, tell your doctor if you have any heart problems or defects. Your doctor will likely check for heart problems before prescribing Mydayis to make sure it’s safe for you to take.

They’ll also likely monitor your blood pressure and heart rate while you’re taking Mydayis. If you develop an increased heart rate or high blood pressure, your doctor may recommend a different medication to treat your condition.

If you experience any unexplained fainting, shortness of breath, or chest pain during treatment with Mydayis, call your doctor right away. If you feel your symptoms are life threatening, call 911 or your local emergency number.

ALLERGIC REACTION

For some people, Mydayis can cause an allergic reaction. The symptoms of allergic reaction can be mild or serious.

Ways to manage

For mild allergic reaction symptoms, such as a mild rash, call your doctor right away. They may recommend treatments to help manage your symptoms. They’ll also let you know whether you should keep taking the medication.

For severe allergic reaction symptoms, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms require immediate medical care because they can become life threatening. If you’ve had a serious allergic reaction to Mydayis, your doctor may recommend taking a different medication instead.

Below is important information you should consider before taking Mydayis.

Mydayis has a boxed warning. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section.

Before taking Mydayis, discuss your health history with your doctor. Mydayis may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:

Other precautions

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.