Nayzilam (midazolam) is a brand-name nasal spray that’s prescribed for a type of seizure that occurs due to epilepsy. The cost of the drug with and without insurance can depend on several factors.

As with all medications, the cost of Nayzilam nasal spray can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • whether Nayzilam has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Nayzilam will be for you, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your Nayzilam prescription, explore these Optum Perks coupons.

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Save on Nayzilam without insurance.

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2 nayzilam (1 Nasal Spray)

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Simply show the Optum Perks coupon at your preferred pharmacy or order online and instantly save up to 80% without using insurance. The coupon doesn’t expire, so be sure to save it for refills.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

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Nayzilam is only available as a brand-name drug. There is currently not a Nayzilam generic drug available. A generic drug is an exact copy of the active ingredient in a brand-name medication.

Generics tend to cost less than brand-name drugs.


Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions. This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

If you need financial support to pay for Nayzilam, or if you need help understanding your insurance coverage, help is available. For example:

  • A Nayzilam coupon called Nayzilam Patient Savings Card is available for Nayzilam. For more information and to find out if you’re eligible for support, call 1-888-786-5879 or visit the program website.
  • The Nayzilam manufacturer, UCB, also has a Patient Assistance Program available for this medication. For more information, call 877-785-8906 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Here are answers to some frequently asked questions about drug cost and Nayzilam.

Can I buy midazolam (Nayzilam) nasal spray online?

No, you cannot buy Nayzilam nasal spray online. This drug is only available with a prescription from your doctor. You cannot purchase the drug over the counter.

If your doctor prescribes Nayzilam, you can have your prescription filled at your local phamacy. Nayzilam comes in a 5-milligram (mg) nasal spray. Ask your pharmacist about the cost of Nayzilam for you. The cost of this drug may depend on many factors, including your insurance plan and the pharmacy you use. If you have questions or concerns about the cost of Nayzilam, be sure to ask your doctor or pharmacist.

How much does Nayzilam cost with insurance?

If you have insurance, your cost for Nayzilam depends on factors such as:

  • your particular plan benefits, including your drug copay amount
  • your Nayzilam dose
  • whether you apply and qualify for a cost savings program

To find out how much Nayzilam will cost you with insurance, contact your insurance provider or doctor.

You can also visit Optum Perks* for price estimates for Nayzilam when using coupons from the site. However, Optum Perks coupons cannot be used with any insurance benefits or copays.

* Optum Perks is a sister site of Medical News Today.

Below is information you may want to consider if you have insurance and receive Nayzilam.

If you have insurance, your insurance company may require prior authorization before it covers Nayzilam. This means the company and your doctor will discuss Nayzilam in regard to your treatment. The insurance company will then determine whether the medication is covered.

If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Nayzilam requires prior authorization.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.