Oriahnn (elagolix/estradiol/norethindrone) is a brand-name drug that’s prescribed for heavy menstrual bleeding due to uterine fibroids in certain adults. Oriahnn comes as an oral capsule that’s typically taken twice per day.

Oriahnn contains three drugs:

  • elagolix, a gonadotropin-releasing hormone antagonist
  • estradiol, an estrogen
  • norethindrone acetate, a progestin

Oriahnn isn’t available in a generic version.

Keep reading for specific information about the dosage of Oriahnn, including its strength and how to take the medication. For a comprehensive look at Oriahnn, see this article.

Note: This article describes the typical dosage of Oriahnn provided by the drug’s manufacturer. When taking Oriahnn, always follow the dosage prescribed by your doctor.

Below is information about Oriahnn’s recommended dosage.

Oriahnn form and strength

Oriahnn comes as a package of two types of oral capsules in the following strengths:

  • white and yellow capsules: 300 milligrams (mg) elagolix, 1 mg estradiol, and 0.5 mg norethindrone acetate
  • white and blue capsules: 300 mg elagolix

Typical dosages

The following information describes the dosage that’s commonly prescribed or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for heavy menstrual bleeding due to uterine fibroids

Doctors may prescribe Oriahnn to treat heavy menstrual bleeding due to uterine fibroids. It’s prescribed for this purpose in adult females* who have not gone through menopause.

If your doctor prescribes Oriahnn, you’ll take two capsules per day: one white and yellow capsule in the morning and one white and blue capsule in the evening.

For more information about your specific dosage, talk with your doctor.

* Sex and gender exist on spectrums. Use of the term “female” in this article refers to sex assigned at birth.

Long-term treatment

Oriahnn is taken for the shortest amount of time needed to treat this condition. Doctors may prescribe Oriahnn for up to 2 years.

Talk with your doctor if you have questions about how long you can expect to take Oriahnn.

Oriahnn comes as two types of capsules you swallow whole. Do not divide, crush, chew, or place the capsules in water. You may take your dose with or without food.

Oriahnn is taken once in the morning and once in the evening. It may be helpful to take your Oriahnn doses around the same time every day. This helps maintain a steady level of the drug in your body so Oriahnn can work effectively.

If you have trouble swallowing capsules, see this article for tips on how to take this form of medication. (Note that the manufacturer of Oriahnn has not stated whether the capsules can be opened and the contents sprinkled on soft food such as applesauce.)

If you have questions about how to take Oriahnn, talk with your doctor or pharmacist. You can also view the drug manufacturer’s instructions for taking Oriahnn.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

What to do for a missed dose of Oriahnn depends on when you remember that you’ve missed a dose. If it’s within 4 hours of the scheduled time, take the missed dose. But if it’s been more than 4 hours since your dose was due, skip the missed dose. Then take your next dose at the regularly scheduled time.

Do not take two doses at once to make up for the missed one. If you’re not sure whether to take a missed dose or skip it, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.

It’s important that you do not take more Oriahnn than your doctor prescribes. For some medications, taking more than the recommended amount may lead to harmful effects or overdose.

Effects of an overdose

Overdose effects of Oriahnn can include:

If you take more than the recommended amount of Oriahnn

Call your doctor right away if you believe you’ve taken too much Oriahnn. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Below are some frequently asked questions about Oriahnn.

How long does it take for Oriahnn to start working?

Oriahnn starts to work after your first dose. Because of how the drug works, you likely won’t feel the drug working in your body. But your doctor will monitor you during treatment to check whether the drug is working to treat your condition.

Talk with your doctor if you have questions about what to expect with Oriahnn treatment.

Is the dosage of Oriahnn similar to the dosage of Myfembree?

No, the dose in mg and how often you take each drug are different. Oriahnn is an oral capsule that’s taken twice per day. Myfembree (relugolix/estradiol/norethindrone) is an oral tablet that’s taken once per day.

Both Oriahnn and Myfembree may be prescribed to treat heavy menstrual bleeding that’s due to uterine fibroids. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

The dosage in this article is the typical dosage provided by the drug’s manufacturer. If your doctor recommends Oriahnn for you, they’ll prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Oriahnn without your doctor’s recommendation. If you have questions about the dosage of Oriahnn that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Oriahnn. These additional articles might be helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.