Orladeyo (berotralstat) is a brand-name drug that’s prescribed to prevent attacks of hereditary angioedema (HAE) in adults and some children. Orladeyo comes as a capsule that’s taken by mouth once per day. The dosage can vary.

Orladeyo is approved by the Food and Drug Administration (FDA) to prevent attacks of hereditary angioedema (HAE) before they happen. It can be used in adults and children ages 12 years and older.

It’s important to note that this medication does have a limitation of use. It should not be used to treat an HAE attack that is already occurring. It’s not known if the drug may be safe or effective to treat an HAE attack.

Orladeyo belongs to a drug class called plasma kallikrein blockers. Orladeyo is not available in a generic version.

Keep reading for specific information about the dosage of Orladeyo, including its strengths and how to take the medication. For a comprehensive look at Orladeyo, see this article.

Note: This article describes typical dosages for Orladeyo provided by the drug’s manufacturer. When taking Orladeyo, always follow the dosage prescribed by your doctor.

The information below describes Orladeyo’s typical dosages and other details about the drug.

Orladeyo form

Orladeyo comes as an oral capsule that’s taken by mouth.

Orladeyo strengths

Orladeyo comes in two strengths: 110 milligrams (mg) and 150 mg.

Typical dosages

The following information describes dosages that are commonly prescribed. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those shown below.

Dosage to prevent hereditary angioedema attacks

Doctors may prescribe Orladeyo to prevent hereditary angioedema (HAE) attacks from occurring.

If your doctor prescribes Orladeyo to prevent HAE attacks, your dose will likely be 150 mg. Typically, you’ll take this dose once daily with food. This is the maximum dose of Orladeyo that’s recommended.

For more information about your specific dosage, talk with your doctor.

Children’s dosage

Orladeyo is approved to prevent HAE attacks in children ages 12 years and older. The recommended dosage for children taking Orladeyo is the same as the adult dosage. Children taking the drug would also take one 150-mg capsule once daily with food.

Talk with your child’s doctor if you have questions about their dosage.

How to take Orladeyo

Orladeyo comes as an oral capsule that you swallow whole. The manufacturer of Orladeyo doesn’t specify if it may be safe to divide, crush, chew, or dissolve the capsule in water. If you have trouble swallowing capsules, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.

Be sure to take your dose of Orladeyo with food.

It may be helpful to take Orladeyo around the same time of day. This helps maintain a steady level of the drug in your body so Orladeyo can work effectively.

If you have questions about how to take Orladeyo, talk with your doctor or pharmacist.

Long-term treatment

Orladeyo is meant to be taken as a long-term treatment option. If you and your doctor determine that Orladeyo is safe and effective for you, you’ll likely take it long term.

Before you start taking Orladeyo, your doctor will discuss your treatment plan with you.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Orladeyo in an easy-open container. They also may recommend tools that can make it easier to open bottles.

It’s important that you don’t take more Orladeyo than your doctor prescribes. For some medications, taking more than the recommended amount may lead to harmful effects or overdose.

Effects of an overdose

Taking too much Orladeyo can cause a heart rhythm problem called QT prolongation. Symptoms of QT prolongation may include:

If you take more than the recommended amount of Orladeyo

Call your doctor right away if you believe you’ve taken too much Orladeyo. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

If you have additional questions about your dosage of Orladeyo or how to take your medication, talk with your doctor or pharmacist.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.