Poteligeo (mogamulizumab-kpkc) is a brand-name drug that’s prescribed for certain types of lymphoma in adults. Poteligeo comes as an injection that’s given by a healthcare professional. The dosage will depend on your body weight in kilograms.

Poteligeo is approved by the Food and Drug Administration (FDA) to treat certain forms of cutaneous T-cell lymphoma (CTCL) in adults, including:

  • relapsed (comes back after being treated) or refractory (hasn’t improved after other treatments) mycosis fungoides
  • Sézary syndrome after at least one other systemic therapy (treatment that affects your entire body) has been used

Poteligeo is a biologic and belongs to a drug class called CC chemokine receptor type 4 (CCR4)-directed monoclonal antibodies. Poteligeo is not available in a biosimilar version.

Keep reading for specific information about the dosage of Poteligeo, including its strength and how the medication is given. For a comprehensive look at Poteligeo, see this article.

Note: This article describes typical dosages for Poteligeo provided by the drug’s manufacturer. However, your doctor will prescribe the Poteligeo dosage that’s right for you.

The information below describes Poteligeo’s typical dosages and other details about the drug.

Poteligeo form

Poteligeo comes as a solution that’s given as an intravenous (IV) infusion. An IV infusion means that the drug is injected into your vein over time. It’s always given by a healthcare professional.

Poteligeo strength

Poteligeo comes in one strength of 4 milligrams per milliliter of solution (mg/mL).

Typical dosages

The following information describes dosages that are commonly used or recommended in adults. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those shown below.

Dosage for mycosis fungoides

Doctors may prescribe Poteligeo to treat mycosis fungoides.

Doctors typically prescribe a dosage of Poteligeo based on your body weight in kilograms (kg). For your reference, 1 kg is about 2.2 pounds (lb). The recommended dosage of Poteligeo is 1 milligram per kilogram (mg/kg). This means if you weigh 68 kg (about 150 lb), your doctor would prescribe a dose of 68 mg.

During your first 28-day cycle, you’ll usually receive Poteligeo every 7 days (on days 1, 8, 15, and 22). In the following cycles, you’ll typically receive Poteligeo every 14 days (on days 1 and 15). This will likely be your dosing schedule unless your condition worsens or you develop side effects.

Poteligeo will be given by your doctor or another healthcare professional as an intravenous (IV) infusion. For details, see the “How Poteligeo is given” section below.

For more information about your specific dosage, talk with your doctor.

Dosage for Sézary syndrome

Poteligeo is also approved to help treat Sézary syndrome. The recommended dosage for Sézary syndrome is the same as for mycosis fungoides. For details, refer to the “Dosage for mycosis fungoides” section above.

Your doctor or another healthcare professional will give you the intravenous (IV) infusion of Poteligeo. They’ll prepare the liquid solution for infusion. You’ll likely go to your doctor’s office, infusion center, or a hospital to receive your infusion. The infusion usually takes about 1 hour.

Long-term treatment

Poteligeo is meant to be given as a long-term treatment. If you and your doctor determine that Poteligeo is safe and effective for you, you’ll likely receive it long term.

Before you start taking Poteligeo, your doctor will discuss your treatment plan with you.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.