ProAir is a brand-name prescription drug. It’s FDA-approved to:

  • Help prevent or treat bronchospasm in people who have reversible obstructive airway disease. Bronchospasm is a tightening of your airways, which can make it difficult to breathe. An example of reversible obstructive airway disease is asthma.
  • Help prevent bronchospasm caused by exercise.

ProAir is approved for use in adults as well as children ages 4 years and older.

ProAir is a rescue inhaler. You use it when you need to breathe more easily due to bronchospasm.

ProAir comes in three different forms, which are explained below.

ProAir HFA vs. ProAir RespiClick vs. ProAir Digihaler

Here are the forms that ProAir comes in:

  • ProAir HFA. This is a metered-dose inhaler that releases the drug as a fine mist.
  • ProAir RespiClick. Thisis a dry powder inhaler that releases the drug as a powder.
  • ProAir Digihaler. This is a dry powder inhaler as well. But it also has an electrical part that lets you connect the inhaler to a mobile app on your phone. The app can tell you how well you’re inhaling the medication.

These forms are all approved by the Food and Drug Administration (FDA) to treat the conditions mentioned above. The three inhalers also contain the same active drug: albuterol sulfate. This drug belongs to a group of medications called beta-adrenergic agonists.

The three ProAir inhaler types all come in a strength of 90 micrograms (mcg) per puff.

Effectiveness

For information about the effectiveness of ProAir, see the “ProAir uses” section below.

ProAir HFA is a brand-name drug that contains the active drug albuterol sulfate. This active drug is also available as a generic medication. A generic drug is an exact copy of the active drug in a brand-name medication.

The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.

If you’re interested in using the generic form of ProAir, talk with your doctor. They can tell you if it comes in forms and strengths that can be used for your condition.

ProAir RespiClick and ProAir Digihaler are available only as brand-name medications. They do not currently come in generic form.

As with all medications, the cost of ProAir can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Keep in mind that you may be able to get a 90-day supply of ProAir. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, talk with your doctor or your insurance company.

Before approving coverage for ProAir, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered.

If you’re not sure if you’ll need to get prior authorization for ProAir, contact your insurance company.

Financial and insurance assistance

If you need financial support to pay for ProAir, or if you need help understanding your insurance coverage, help may be available.

To find ways to save on your ProAir prescription, check out Medicine Assistance Tool’s website.

Also, Teva Respiratory LLC, the manufacturer of ProAir Digihaler, offers a savings program that may lower the cost of its drug. For more information and to find out if you’re eligible for support, visit the program website.

Mail-order pharmacies

ProAir may be available through a mail-order pharmacy. Using this service may help lower the drug’s cost and allow you to get your medication without leaving home.

If recommended by your doctor, you may be able to receive a 90-day supply of ProAir, so there’s less concern about running out of the medication. If you’re interested in this option, check with your doctor and your insurance company. Some Medicare plans may help cover the cost of mail-order medications.

If you don’t have insurance, you can ask your doctor or pharmacist about online pharmacy options.

Generic version

ProAir HFA is available in a generic form called albuterol sulfate. A generic drug is an exact copy of the active drug in a brand-name medication. The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.

If your doctor has prescribed ProAir and you’re interested in using albuterol sulfate instead, talk with your doctor. They may prefer one version or the other. You’ll also need to check your insurance plan, as it may only cover one or the other.

ProAir RespiClick and ProAir Digihaler are available only as brand-name medications. They do not currently come in generic form.

You should use ProAir according to the instructions your doctor or other healthcare professional gives you.

ProAir comes as an inhaler. This device releases the medication as puffs, which you inhale. The three different types of ProAir inhalers are:

  • ProAir HFA. This is a metered-dose inhaler that releases the drug as a fine mist.
  • ProAir RespiClick. Thisis a dry powder inhaler that releases the drug as a powder.
  • ProAir Digihaler. This is a dry powder inhaler as well. But it also has an electrical part that lets you connect the inhaler to a mobile app on your phone. The app can give you information such as how strongly you breathe ProAir into your airways. This helps determine how well the medication may work. Keep in mind that you don’t have to connect to the mobile app to receive your dose.

How to use ProAir inhalers depends on which inhaler you’re prescribed. For details on how to use and clean your inhaler, see the instructions for your particular form: ProAir HFA, ProAir RespiClick, or ProAir Digihaler. You can also talk with your doctor or pharmacist.

When to use

You should use your ProAir inhaler only as your doctor recommends. To help prevent or treat bronchospasm (tightening of the airways), you’ll usually use the medication every 4 to 6 hours.

If you use ProAir more than 2 days per week to help prevent or treat bronchospasm, talk with your doctor. Your dose of maintenance medication may need to be adjusted. These medications work long term to help prevent bronchospasm symptoms. If you use ProAir more than recommended, it could mean that your maintenance medication isn’t working as well as it should.

To help prevent bronchospasm caused by exercise, you’ll likely use ProAir 15 to 30 minutes before exercising.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or timer on your phone or downloading a reminder app. A kitchen timer can work, too.

The ProAir dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using ProAir to treat
  • the form of ProAir you use
  • other medical conditions you may have

Your doctor may adjust your dose over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. But be sure to use the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

ProAir comes as an inhaler. This device releases the medication as puffs, which you inhale. The three different types of ProAir inhalers are:

  • ProAir HFA. This is a metered-dose inhaler that releases the drug as a fine mist.
  • ProAir RespiClick. Thisis a dry powder inhaler that releases the drug as a powder.
  • ProAir Digihaler. This is a dry powder inhaler as well. But it also has an electrical part that lets you connect the inhaler to a mobile app on your phone. The app can tell you how well you’re inhaling the medication.

All three forms of ProAir inhalers come in a strength of 90 micrograms (mcg) per puff.

To help prevent or treat an episode of bronchospasm, the dosage is the same for the three forms of ProAir. A bronchospasm is a tightening of the airways.

Dosage for helping prevent or treat bronchospasm

The recommended ProAir dosage to help prevent or treat bronchospasm is two puffs every 4 to 6 hours if needed. If your episode isn’t severe, your doctor may recommend one puff every 4 to 6 hours.

ProAir is a rescue inhaler, which means you use it only when you need to breathe easier because of bronchospasm.

If you use ProAir more than 2 days per week, talk with your doctor. It could mean that your maintenance medication isn’t working well enough, and the dosage may need to be adjusted. Maintenance medication works long term to help prevent bronchospasm. You’ll likely take such a drug with ProAir. To learn more, see the “ProAir use with other drugs” section below.

Dosage for helping prevent bronchospasm caused by exercise

To help prevent bronchospasm from occurring while exercising, the dosage is the same for the three forms of ProAir (mentioned above).

The recommended dosage is two puffs 15 to 30 minutes before exercising.

Children’s dosage

ProAir is approved for use in children ages 4 years and older. The dosages are the same as those for adults. For details, see “Dosage for helping prevent or treat bronchospasm” and “Dosage for helping prevent bronchospasm caused by exercise” above.

What if I miss a dose?

If you use ProAir to help prevent or treat bronchospasm, you’ll use the medication only if you have difficulty breathing.

If you forget to take a dose of ProAir before exercising, take it as soon as you remember.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or timer on your phone or downloading a reminder app. A kitchen timer can work, too.

Will I need to use this drug long term?

ProAir is meant to be used as a long-term treatment. But it is often only used as needed for symptoms of bronchospasm. If you and your doctor determine that ProAir is safe and effective for you, you’ll likely use it long term to treat or help prevent bronchospasm.

ProAir can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while using ProAir. These lists do not include all possible side effects.

For more information about the possible side effects of ProAir, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with ProAir, you can do so through MedWatch.

Mild side effects

Mild side effects* of ProAir can include:

Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

* This is a partial list of mild side effects from ProAir. To learn about other mild side effects, talk with your doctor or pharmacist. You can also view the patient information for the ProAir form you’re using: ProAir HFA, ProAir RespiClick, or ProAir Digihaler.

Serious side effects

Serious side effects from ProAir aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

* For more information about this side effect, see “Side effect details” below.

Side effect details

Here’s some detail on certain side effects this drug may cause.

Paradoxical bronchospasm

It’s possible that people using ProAir may experience paradoxical bronchospasm, which is unexpected tightening of the airways. ProAir is meant to open up your airways and make it easier to breathe. But sometimes after taking a dose your airways may tighten up. This can make it difficult to breathe.

Symptoms of paradoxical bronchospasm can include:

If you develop paradoxical bronchospasm, talk with your doctor right away. They’ll typically have you stop using ProAir and try a different medication to help you breathe better. If you have difficulty breathing after taking a dose of ProAir, call 911 or your local emergency number, or go to your nearest emergency room.

To find out how often paradoxical bronchospasm occurred in clinical trials, see the prescribing information for the ProAir form you use: ProAir HFA, ProAir RespiClick, or ProAir Digihaler.

If you have any questions about paradoxical bronchospasm and ProAir, talk with your doctor or pharmacist.

Heart problems

The use of ProAir may cause heart problems, such as increases in heart rate and blood pressure. Heart problems are a common side effect that may occur in people using this medication.

Symptoms of tachycardia (fast heart rate) may include:

Increased blood pressure usually doesn’t cause symptoms, but when it’s very high, symptoms can include:

If you develop any of these symptoms while using ProAir, talk with your doctor right away. Your doctor may switch you to a different medication to help with your breathing. If your symptoms feel serious, call 911 or your local emergency number, or go to your nearest emergency room.

To find out how often an increased heart rate occurred in clinical trials, see the prescribing information for the ProAir form you use: ProAir HFA, ProAir RespiClick, or ProAir Digihaler.

If you have questions about an increased heart rate and ProAir, talk with your doctor or pharmacist.

Allergic reaction

As with most drugs, some people can have an allergic reaction after using ProAir. It isn’t known how often allergic reactions occurred in clinical studies of ProAir HFA, ProAir RespiClick, or ProAir Digihaler.

Symptoms of a mild allergic reaction can include:

  • skin rash
  • itchiness
  • flushing (temporary warmth, redness, or deepening of skin color)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under your skin, typically in your eyelids, lips, hands, or feet
  • swelling of your tongue, mouth, or throat
  • trouble breathing

Call your doctor right away if you have an allergic reaction to ProAir, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

The Food and Drug Administration (FDA) approves prescription drugs such as ProAir to treat certain conditions. ProAir may also be used off-label for other conditions. Off-label drug use means using a drug for a purpose other than what it’s been approved for by the FDA.

ProAir for bronchospasm

ProAir is FDA-approved for use in adults as well as children ages 4 years and older to:

ProAir is a rescue inhaler, which is a short-acting medication. You use it when you need to breathe more easily due to bronchospasm.

ProAir comes in three different forms: ProAir HFA, ProAir RespiClick, and ProAir Digihaler. For details on these forms, see the “How to use ProAir” section above.

About bronchospasm

Bronchospasm is a tightening of your airways, which can make it difficult for you to breathe. Symptoms of bronchospasm may include:

Reversible obstructive airway diseases are conditions that can cause trouble breathing for a time. These conditions include asthma, emphysema, and chronic bronchitis.

Effectiveness for bronchospasm

ProAir is an effective treatment option for people who experience bronchospasm. For more information on how ProAir performed in clinical trials, see the prescribing information for ProAir HFA, ProAir RespiClick or ProAir Digihaler.

The Global Initiative for Asthma (GINA) recommends the use of drugs called short-acting beta agonists for people who have bronchospasm due to asthma. (ProAir is a type of short-acting beta agonist.) In addition, GINA recommends the use of these medications to help prevent bronchospasm that’s caused by exercise.

ProAir and children

All forms of ProAir are approved for use in children ages 4 years and older to treat the same conditions as in adults. For details, see “ProAir for bronchospasm” above.

It is not known if ProAir inhalers are safe or effective in children younger than 4 years old.

ProAir is a rescue inhaler, which is a short-acting medication. It opens airways quickly, so it’s used when breathing becomes difficult. In certain cases, it’s used to help prevent trouble breathing.

You’ll likely need to use other drugs to help lower your risk for bronchospasm (tightening of the airways). These drugs can include maintenance medications, which help prevent bronchospasm from occurring. You’ll usually use maintenance medication every day. Examples of maintenance inhalers that you may use in combination with ProAir include:

There are also oral medications that may help reduce your risk for bronchospasm or treat swelling in your airways. Your doctor may recommend that you take them in combination with a ProAir inhaler to treat your condition. Examples of these oral medications include:

Talk with your doctor about the best treatment plan for you. They’ll typically recommend a maintenance medication along with a rescue inhaler to treat your bronchospasm.

There are no known interactions between ProAir and alcohol.

ProAir can interact with several other medications. It can also interact with certain supplements as well as certain foods.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase the number of side effects or make them more severe.

ProAir and other medications

Below is a list of medications that can interact with ProAir. This list does not contain all drugs that may interact with ProAir.

Before using ProAir, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Types of drugs that can interact with ProAir include:

  • Beta-blockers.Beta-blocker medications can cause ProAir to not work as well as usual. If you take a beta-blocker, talk with your doctor. They may recommend a medication other than a beta-blocker. Examples of beta-blockers include:
  • Certain diuretics. Using diuretic medications and ProAir can cause your potassium level to become too low.* If you take a diuretic medication, talk with your doctor before you start using ProAir. They may recommend a different type of diuretic for you. Examples of diuretics that may interact with ProAir include:
  • Digoxin (Lanoxin). ProAir may make digoxin less effective than usual at treating heart problems. If you take digoxin, talk with your doctor before you start using ProAir. They may monitor your digoxin blood levels more often than usual to see whether the medication is working properly.
  • Monoamine oxidase Inhibitors. The combination of ProAir and monoamine oxidase inhibitors (MAOIs) can increase your risk for heart problems. You should avoid using ProAir while taking an MAOI and for at least 2 weeks after stopping the MAOI treatment. Examples of MAOIs include:
    • selegiline (Emsam, Zelapar)
    • phenelzine (Nardil)
    • tranylcypromine (Parnate)
  • Tricyclic antidepressants. Using ProAir and a tricyclic antidepressant can cause an increased risk of heart problems. You should avoid using ProAir while taking a tricyclic antidepressant and for at least 2 weeks after stopping the tricyclic antidepressant treatment. Examples of tricyclic antidepressants include:
    • amitriptyline
    • nortriptyline (Pamelor)
    • desimpramine (Norpramin)
    • doxepin (Silenor)

* For details on low potassium levels, see “Side effect details” in the “ProAir side effects” section above.

ProAir and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with ProAir inhalers. However, you should still check with your doctor or pharmacist before using any of these products while using ProAir.

ProAir and foods

There aren’t any foods that have been specifically reported to interact with ProAir. If you have any questions about eating certain foods with ProAir, talk with your doctor.

ProAir is a rescue inhaler that comes in three forms: ProAir HFA, ProAir RespiClick, and ProAir Digihaler.* The drug is approved to help prevent and treat bronchospasm that’s related to reversible obstructive airway disease.

Bronchospasm is a tightening of your airways, which can make it difficult for you to breathe. Reversible obstructive airway diseases are conditions such as asthma, which can make it hard to breathe for a time.

ProAir works by relaxing the muscles in your airways that tighten up during bronchospasm. By loosening these muscles, you can inhale more air and breathe better.

* For details on the forms, see the “How to use ProAir” section above.

How long does it take to work?

ProAir works quickly to help ease your symptoms of bronchospasm. The medication begins working as soon as you inhale it.

It is not known if ProAir is safe to use during pregnancy. There haven’t been any clinical trials to determine the safety of the medication while pregnant.

Some reports were done after ProAir was put on the market. The results didn’t show an increased risk of birth abnormalities (birth defects) or loss of pregnancy in females* who used ProAir while pregnant.

Animal studies showed that when pregnant animals were given albuterol (the active drug in ProAir), their offspring had birth abnormalities. But animal studies don’t always indicate what will happen in humans.

If you’re pregnant or planning to become pregnant, talk with your doctor before using ProAir. They can help determine whether it’s the right medication for you. Keep in mind that in many cases, untreated asthma symptoms may be harmful to pregnant people and fetuses.

* Sex and gender exist on spectrums. Use of the term “female” in this article refers to sex assigned at birth.

Pregnancy registry

There is a pregnancy registry for people who use asthma medications while they’re pregnant. The registry collects information to help determine if a medication is safe to use during pregnancy. For more information about the pregnancy registry, call 877-311-8972 or visit the registry website.

It’s not known if ProAir is safe to use during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re using ProAir.

For more information about using ProAir during pregnancy, see the “ProAir and pregnancy” section above.

It’s not known if ProAir is safe to use while you breastfeed. This is because it’s not known if the drug passes into breast milk or what effects ProAir has on a child who’s breastfed. ProAir is an inhaled medication, so little of the drug is present in blood. This means that a child who’s breastfed would likely be exposed to a low level of the medication.

If you’re breastfeeding or planning to, talk with your doctor before using ProAir. They can advise you on healthy ways to feed your child and whether ProAir is right for you.

Here are answers to some frequently asked questions about ProAir.

What kind of information does ProAir Digihaler collect?

ProAir Digihaler collects data such as how you use the medication and how often you do so.

The ProAir Digihaler can link to a mobile app on your phone. Through the app, you and your doctor can see how strongly you breathe the medication into your airways. This helps determine how well the drug is working.

The app can also record how often you use your inhaler. This may help determine how well managed your bronchospasm is. If you use your ProAir Digihaler often, it could mean that your maintenance medication* isn’t working as well as usual. So your doctor may need to adjust that dosage or recommend a different medication.

If you have more questions about ProAir Digihaler, talk with your doctor or pharmacist.

* For details on maintenance medications, see the “ProAir use with other drugs” section above.

Is ProAir a steroid?

No, ProAir isn’t a steroid medication. ProAir is a type of drug called a beta-adrenergic agonist. It works to relax the muscles in your airways to help you breathe better.

Steroids work by decreasing swelling in your airways, which makes it easier for you to breathe. Other medications that are used for asthma, such as fluticasone (Flovent HFA) and mometasone (Asmanex), are steroids.

If you have other questions about ProAir or steroids, talk with your doctor or pharmacist.

What should I do if ProAir doesn’t help improve my breathing?

If ProAir doesn’t help improve your breathing and you have difficulty breathing, you should seek medical attention right away, by calling 911 or going to your nearest emergency room. This can be very serious or life threatening if you are not treated right away.

Before using ProAir, talk with your doctor about your health history. ProAir may not be right for you if you have certain medical conditions or other factors affecting your health. These include:

  • Heart problems. ProAir can increase your heart rate or blood pressure, or cause changes in your heart rhythm. If you have any heart problems, talk with your doctor before you start using ProAir. They may monitor your heart while you use the medication or recommend a different treatment option.
  • Seizures. Although rare, it’s possible that ProAir can worsen seizures in people with seizure disorders. If you have a seizure disorder, talk with your doctor before you start using the medication. They can help determine whether ProAir is right for you.
  • High blood pressure. ProAir can increase your blood pressure. If you already have high blood pressure, using ProAir can raise it even further, which can become serious. Your doctor will typically make sure that your blood pressure is well controlled before you start using ProAir. They may monitor it throughout your treatment with ProAir as well.
  • Thyroid problems. If you have thyroid problems, such as an overactive thyroid, talk with your doctor before you start using ProAir. Using the medication can make your thyroid condition worse. Your doctor can help you determine if ProAir is right for you.
  • Allergic reaction. If you’ve had an allergic reaction to ProAir or any of its ingredients, you should not use ProAir. Ask your doctor what other medications are better options for you.
  • Milk allergy. You should not use ProAir RespiClick or ProAir Digihaler if you have a severe milk allergy. In rare cases, people with a milk allergy experienced severe allergic reactions due to an ingredient in these forms called lactose. Ask your doctor about treatments other than ProAir RespiClick or ProAir Digihaler if you have a severe milk allergy.
  • Pregnancy. It’s not known if ProAir is safe to use during pregnancy. For more information, see the “ProAir and pregnancy” section above.
  • Breastfeeding. It’s not known if ProAir is safe to use while you’re breastfeeding. For more information, see the “ProAir and breastfeeding” section above.
  • Diabetes. The use of ProAir can increase your blood sugar levels. So if you have diabetes, talk with your doctor before you start using ProAir. They may recommend that your blood glucose levels be monitored more frequently than usual.
  • Low potassium level in your blood. ProAir may cause a low potassium level. If you already have a low potassium level in your blood, using ProAir can decrease your level further. Low potassium levels can be serious and may lead to muscle cramping or problems with your heart rhythm. Before using ProAir, talk with your doctor. They may recommend a potassium supplement if you have a low level of potassium.

Note: For more information about the potential negative effects of ProAir, see the “ProAir side effects” section above.

Using more than the recommended dosage of ProAir can lead to serious side effects. Do not use more ProAir than your doctor recommends.

Overdose symptoms

Symptoms of an overdose can include:

What to do in case of overdose

If you think you’ve used too much of this drug, call your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.

When you get ProAir from the pharmacy, the pharmacist will add an expiration date to the label on the box. This date is typically 1 year from the date they dispensed the medication.

The expiration date helps guarantee that the medication is effective during this time. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. If you have unused medication that has gone past the expiration date, talk with your pharmacist about whether you might still be able to use it.

Storage

How long a medication remains good to use can depend on many factors, including how and where you store the medication.

You should store ProAir at room temperature, between 59°F and 77°F (15°C and 25°C). Keep your ProAir inhaler away from extreme heat, humidity, and cold temperatures. It’s important to note that ProAir HFA canisters are pressurized and can burst if exposed to extreme temperatures.

Disposal

If you no longer need to use ProAir and have leftover medication, it’s important to dispose of it safely. This helps prevent others, including children and pets, from using the drug by accident. It also helps keep the drug from harming the environment.

If you use ProAir Digihaler, keep in mind that it contains a lithium battery. Be sure to look into your local community guidelines on the best way to dispose of a lithium battery.

This article provides several useful tips on medication disposal. You can also ask your pharmacist for information about how to dispose of your medication.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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