Reblozyl (luspatercept-aamt) is a brand-name drug prescribed for anemia in certain adults. Reblozyl comes as a subcutaneous injection that’s given by a healthcare professional once every 3 weeks. The dosage can vary depending on what condition the drug is used to help treat.
Reblozyl is approved by the Food and Drug Administration (FDA) to treat anemia in adults who need red blood cell transfusions regularly and have:
Keep reading for specific information about the dosage of Reblozyl, including its strengths and how to use the medication. For a comprehensive look at Reblozyl, see this article.
Note: This article describes typical dosages for Reblozyl provided by the drug’s manufacturer. However, your doctor will prescribe the Reblozyl dosage that’s right for you.
The information below describes Reblozyl’s typical dosages and other details about the drug.
Reblozyl comes as a powder that’s mixed into a solution by a healthcare professional. It’s given as a subcutaneous injection. Your doctor or another healthcare professional will give your injections at your doctor’s office.
Reblozyl comes in two strengths: 25 milligrams (mg) and 75 mg.
The following information describes dosages that are commonly prescribed in adults. Your doctor will determine the best dosage to fit your needs.
Dosage for anemia
If your doctor prescribes Reblozyl for your anemia, your starting dose will be based on your body weight. Typically, your dose will be 1 mg per kilogram (kg) of body weight (mg/kg). For reference, 1 kg equals about 2.2 pounds. Generally, you’ll get this dose once every 3 weeks.
Your doctor will test your blood throughout your treatment to see how you’re responding to the medication. After two doses of Reblozyl, they may recommend increasing your dosage.
If you have beta-thalassemia
If you have beta-thalassemia, your doctor may increase your dose to 1.25 mg/kg. This is the maximum recommended dosage of Reblozyl for beta thalassemia.
If you have myelodysplastic disease
If you have myelodysplastic disease, your doctor may increase your dose to 1.33 mg/kg. After two additional doses, if you’re still not responding well, your doctor may increase your dose to 1.75 mg/kg. This is the maximum dosage of Reblozyl recommended for this condition.
If you’ve taken three doses (9 weeks) of Reblozyl at the maximum dosage recommended for your condition and you’re still not noticing improvement, your doctor may recommend stopping Reblozyl and trying a different treatment option for your anemia.
For more information about your specific dosage, talk with your doctor.
Reblozyl is meant to be used as a long-term treatment. If you and your doctor determine that Reblozyl is safe and effective for you, you’ll likely use it long term.
Before you start taking Reblozyl, your doctor will discuss your treatment plan with you.
The Reblozyl dosage your doctor prescribes will depend on several factors. These include:
Other medical conditions you have can also affect your Reblozyl dosage.
Reblozyl comes as a powder that a healthcare professional will mix into a solution. It’s given as a subcutaneous injection.
With a subcutaneous injection, a healthcare professional will inject the medication under your skin. It’s not recommended to give yourself a dose of Reblozyl. You’ll go to your doctor’s office each time you need a dose of medication. A healthcare professional will inject Reblozyl under the skin of your upper arm, thigh, or stomach.
If you have questions about Reblozyl, talk with your doctor or pharmacist.
If you miss your appointment for a Reblozyl injection, call your doctor’s office as soon as possible to reschedule. They’ll adjust your dosing schedule as needed. You’ll need at least 3 weeks between your Reblozyl doses.
If you need help remembering your appointments, try setting an alarm or downloading a reminder app on your phone.
Below are some frequently asked questions about Reblozyl.
How long does it take for Reblozyl to start working?
Reblozyl starts to work after your first dose. However, it may take a few weeks before you notice a change, such as needing fewer RBC transfusions. Throughout your treatment with Reblozyl, your doctor will monitor your blood. They can determine how well Reblozyl is working for you based on your blood tests.
Talk with your doctor if you have questions about what to expect with Reblozyl treatment.
What is the recommended maximum dosage of Reblozyl?
The maximum dosage of Reblozyl that’s recommended depends on which condition you’re using Reblozyl for. Your dosage of Reblozyl will be based on your body weight.
If you’re treating beta-thalassemia, the maximum recommended dosage is 1.25 mg/kg every 3 weeks. But if you’re treating myelodysplastic syndrome, the maximum recommended dosage is 1.75 mg/kg every 3 weeks. For details about Reblozyl dosages, see the “Reblozyl dosage” section above.
If you have questions or concerns about your dosage of Reblozyl, talk with your doctor or pharmacist. If it seems like you need a higher dosage, ask your doctor whether a dosage increase is right for you.
The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Reblozyl for you, they will prescribe the dosage that’s right for you.
If you have questions about the dosage of Reblozyl that’s best for you, talk with your doctor.
Besides learning about dosage, you may want other information about Reblozyl. These additional articles might be helpful:
- More about Reblozyl: For information about other aspects of Reblozyl, refer to this article.
- Side effects: To learn about side effects of Reblozyl, see the Reblozyl prescribing information.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.