Rybrevant (amivantamab-vmjw) is a brand-name intravenous (IV) infusion prescribed for certain types of non-small cell lung cancer (NSCLC) in some adults. The cost of the drug, with and without insurance, can depend on several factors.

Rybrevant is approved by the Food and Drug Administration (FDA) to treat a specific type of EGFR-positive NSCLC in adults. (“EGFR” stands for epidermal growth factor receptor.)

Read on to learn about the cost of Rybrevant. For a comprehensive look at the drug, including details about its uses, see this article.

As with all medications, the cost of Rybrevant can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • the cost of the visit to your healthcare professional to receive doses of Rybrevant
  • whether Rybrevant has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Rybrevant will be for you, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your Rybrevant prescription, explore these Optum Perks coupons.

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Simply show the Optum Perks coupon at your preferred pharmacy or order online and instantly save up to 80% without using insurance. The coupon doesn’t expire, so be sure to save it for refills.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

Optum Perks and Healthline are subsidiaries of RVO Health.

Pricing source:Perks.optum.com


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Rybrevant contains the active ingredient amivantamab-vmjw, and it’s available only as a brand-name biologic drug. It doesn’t come in a biosimilar version. A biosimilar medication is a drug that’s similar to a brand-name biologic drug (the parent drug). Also, biosimilars tend to cost less than brand-name medications.

(The reason “-vmjw” appears at the end of the drug’s name is to show it’s distinct from similar medications that may be created in the future.)


Biologic drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a biologic drug can sell it for up to 12 years. When the biologic drug’s patent expires, multiple manufacturers can create biosimilar versions. This marketplace competition may lead to lower costs for biosimilars. Also, because biosimilars are very similar to biologic drugs, they don’t require the same costly testing.

If you need financial support to pay for Rybrevant, or if you need help understanding your insurance coverage, help is available. For example:

  • A program called Janssen CarePath Savings Program is available for Rybrevant. For more information and to find out whether you’re eligible for support, call 877-227-3728 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Here are answers to some frequently asked questions about drug cost and Rybrevant.

How much does Rybrevant cost with insurance vs. without it?

What you pay for Rybrevant if you have insurance compared with what you’d pay without it depends on several factors.

Factors that could affect what you pay for this drug without insurance include:

  • whether you apply and qualify for any available savings programs
  • your dosage and treatment plan
  • the pharmacy you use
  • the cost of receiving your dose of Rybrevant (this drug is given by IV infusion at your doctor’s office or an infusion center)

These same factors may affect your price for Rybrevant if you have insurance. But the insurance price will also depend on your specific plan benefits and any prior authorization requirements. (For details about this, see “Insurance considerations” below.)

To learn more about what you’d pay for Rybrevant with or without insurance, talk with your doctor, pharmacist, or insurance provider (if you have one).

You can also visit Optum Perks* for price estimates for this drug when using coupons from their site. (Optum Perks is a sister site of Medical News Today.) Note that Optum Perks coupons cannot be used with insurance benefits or copays.

Is Rybrevant covered by Medicare?

Medicare may cover Rybrevant, depending on your specific plan. There are many types of Medicare plans. Your coverage and what you pay for prescriptions will be based on your particular plan’s benefits. You can call your Medicare plan provider to learn whether your plan covers the cost of this drug.

The total price you pay for Rybrevant may also depend on the cost to receive infusions at your doctor’s office or clinic. You may also need to obtain prior authorization before your plan will cover the cost of this medication. (For details about prior approval, see “Insurance considerations” below.)

Your doctor may also be able to provide information about your cost for Rybrevant if you have Medicare.

Below is information you may want to consider if you have insurance and receive Rybrevant.

Prior authorization: If you have insurance, your insurance company may require prior authorization before it covers Rybrevant. This means the company and your doctor will discuss Rybrevant in regard to your treatment. The insurance company will then determine whether to cover the medication.

If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Rybrevant requires prior authorization.

Type of insurance coverage: Rybrevant is given by your doctor or another healthcare professional. If you have insurance, the price of your Rybrevant doses may be billed through your medical coverage instead of the prescription drug portion of your insurance plan. This depends on your specific insurance plan and where you receive your Rybrevant doses, such as at your doctor’s office, an infusion clinic, or a hospital.

If you have questions about this process, contact your doctor or your insurance provider.

Now that you’ve learned about cost and Rybrevant, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Rybrevant. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you’d pay for Rybrevant.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.