Rydapt (midostaurin) is a brand-name drug that’s prescribed for certain types of leukemia and mastocytosis in adults. Rydapt comes as an oral capsule that’s typically taken twice per day.

Rydapt is approved by the Food and Drug Administration (FDA) to treat:

Rydapt belongs to a drug class called kinase inhibitors. Rydapt isn’t available in a generic version.

Keep reading for specific information about the dosage of Rydapt, including its strength and how to take the medication. For a comprehensive look at Rydapt, see this article.

Note: This article describes typical dosages for Rydapt provided by the drug’s manufacturer. When taking Rydapt, always follow the dosage prescribed by your doctor.

Read below for details about Rydapt’s dosages for its approved uses.

Rydapt form

Rydapt comes as an oral capsule.

Rydapt strength

Rydapt comes in one strength of 25 milligrams (mg).

Typical dosages

The following information describes dosages that are commonly prescribed or recommended in adults. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those shown below.

Dosage for acute myeloid leukemia

Doctors may prescribe Rydapt to treat AML in adults with a certain genetic mutation. The drug is taken with other drugs.

If your doctor prescribes Rydapt for your AML, your dosage will likely be 50 mg twice per day. For this dosage, you’ll take two 25-mg capsules twice per day.

Rydapt is given during two phases of AML treatment: induction chemotherapy and consolidation chemotherapy. Each phase typically lasts 21 days.

  • Induction chemotherapy: This is the initial phase of AML treatment. It’s meant to shrink your cancer before you start radiation therapy. During this phase:
    • You’ll receive two chemotherapy drugs: cytarabine for 7 days, and daunorubicin or a similar drug on each of the first 3 days.
    • Then, you’ll take Rydapt on days 8 through 21.
  • Consolidation chemotherapy: This occurs after the induction phase. Its goal is to treat any cancer cells that are still in your body after induction chemotherapy. During this phase:
    • You’ll receive high doses of cytarabine over 5 days.
    • You’ll take Rydapt on days 8 through 21.

For more information about your specific dosage, talk with your doctor.

Dosage for systemic mastocytosis

Rydapt is approved to help treat certain types of systemic mastocytosis. The typical dosage of Rydapt for this condition is 100 mg twice per day. For this dosage, you’ll take four 25-mg capsules twice per day.

Your doctor may adjust your dosage if you experience side effects from Rydapt.

Talk with your doctor if you have questions about your dosage.

How to take Rydapt

Rydapt comes as an oral capsule that you swallow whole. Here are tips on how to take Rydapt:

  • Do not divide, crush, or chew the Rydapt capsules, or place them in water.
  • Be sure to take your Rydapt dose with food.
  • Your doctor will likely recommend that you take an anti-nausea medication during Rydapt treatment. Examples of anti-nausea medications include ondansetron and dexamethasone.
  • It may be helpful to take Rydapt around the same time of day, about every 12 hours. This helps maintain a steady level of the drug in your body so Rydapt can work effectively.
  • If you have trouble swallowing capsules, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.
  • If you miss your dose of Rydapt or vomit after taking it, do not repeat the dose. Take your next dose at the previously scheduled time.

If you have questions about how to take Rydapt, talk with your doctor or pharmacist.

Long-term treatment

The length of your Rydapt treatment depends on the condition you’re taking it for.

Rydapt is taken short-term for AML. Doctors prescribe Rydapt for up to six treatment cycles. Each treatment cycle is typically 21 days long.

Rydapt is meant to be taken as a long-term treatment for mastocytosis. If you and your doctor determine that Rydapt is safe and effective for you, you’ll likely take it until your condition worsens or you develop bothersome side effects from the drug.

Talk with your doctor if you have questions about how long you can expect to take Rydapt.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Rydapt in an easy-open container. They also may recommend tools that can make it easier to open bottles.

It’s important that you do not take more Rydapt than your doctor prescribes. For some medications, taking more than the recommended amount may lead to harmful effects or overdose.

If you take more than the recommended amount of Rydapt

Call your doctor right away if you believe you’ve taken too much Rydapt. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.