Siliq (brodalumab) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat plaque psoriasis in certain adults.

Specifically, Siliq can be used in people who are eligible for systemic therapy (treatment that affects your whole body, such as an injection or pill) or phototherapy. Siliq should only be used in people who have already tried other systemic treatments for plaque psoriasis.

Siliq comes as a solution in a prefilled syringe. The drug is given as a subcutaneous injection.

Siliq is a type of drug called a biologic. It doesn’t have a biosimilar version. Siliq belongs to a drug class called human interleukin-17 receptor A (IL-17RA) blockers.

Dosage summary

The following chart summarizes Siliq’s dosage. Your doctor will determine the dosage that’s best for you.

Siliq formStrengthTypical dosage
solution in a prefilled syringe for subcutaneous injection210 milligrams (mg) per 1.5 milliliters (mL)210 mg once per week for 3 weeks, then 210 mg every 2 weeks

For information about the dosage of Siliq, including its strength and how to take the drug, keep reading. For a comprehensive look at Siliq, see this article.

Before you start treatment with Siliq, your doctor will recommend the best dosage for you.

Siliq form

Siliq comes as a solution in a prefilled syringe that’s given as a subcutaneous injection.

Siliq strength

Siliq comes in one strength: 210 milligrams per 1.5 milliliters of solution (mg/mL).

Typical dosages

The following information describes the Siliq dosing schedule that’s commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for plaque psoriasis

The recommended dosage of Siliq to treat plaque psoriasis is 210 mg. For your first three weeks of treatment with Siliq, you’ll receive a dose of 210 mg once per week. Then, after your first 3 weeks have been completed, you will only need to inject a dose of 210 mg of Siliq once every 2 weeks.

Long-term treatment

Siliq is meant to be a long-term treatment. If you and your doctor determine that Siliq is safe and effective for you, you’ll likely take it long term.

However, if you don’t notice any improvement within 12 to 16 weeks after starting Siliq, tell your doctor. After 12 to 16 weeks, if you haven’t had an improvement in your symptoms, it’s not likely that you will notice improvement if you continue taking Siliq. Your doctor may then recommend that you stop Siliq and try a different treatment option for your plaque psoriasis.

Your doctor or another healthcare professional can show you how to inject Siliq so that you or a caregiver can give your doses at home. Siliq comes in a prefilled syringe that’s ready for use. Be sure to inject the full dose of Siliq with each injection.

Siliq may be stored in the refrigerator until you’re ready for your dose. Be sure to let Siliq come to room temperature for about 30 minutes after taking it out of the refrigerator. Do not try to heat the medication to warm it faster. You also should not shake your prefilled Siliq syringe.

Siliq can be injected into your outer upper arm, stomach area, or thigh. Do not inject Siliq into skin that’s red, discolored, bruised, or tender. You should choose a different injection site with each injection to prevent side effects.

For step-by-step directions on how to inject Siliq, see the drug’s prescribing information. If you have additional questions about how to inject Siliq, talk with your doctor or pharmacist.

To learn more about Siliq’s side effects, see this article.


If you’re having trouble reading your prescription label, talk with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you miss your dose of Siliq, take it as soon as you remember. If it’s close to the time for your next dose, call your doctor or pharmacist to determine when you should take your next dose.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

It’s important that you do not use more Siliq than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects or overdose.

If you take more than the recommended amount of Siliq

Call your doctor right away if you believe you’ve taken too much Siliq. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Siliq for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you.

As with any drug, never change your dosage of Siliq without your doctor’s recommendation. If you have questions about the dosage of Siliq that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Siliq. These additional articles might be helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.