Soliqua 100/33 (insulin glargine and lixisenatide) is a prescription brand-name medication. The Food and Drug Administration (FDA) has approved it to improve blood sugar levels in adults with type 2 diabetes.

Soliqua 100/33 comes as a liquid solution in prefilled injector pens. It is given as a subcutaneous injection.

Soliqua 100/33 contains two drugs:

Soliqua 100/33 is a biologic medication. It’s not available in a biosimilar version.

For information about the dosage of Soliqua 100/33, including its strength and how to take the drug, keep reading. For a comprehensive look at Soliqua 100/33, see this article.

This article describes typical dosages for Soliqua 100/33 provided by the drug’s manufacturer. When taking Soliqua 100/33, always follow the dosage prescribed by your doctor.

Below is information about the typical dosages for Soliqua 100/33. Be sure to always take the dosage of Soliqua 100/33 your doctor prescribes for you.

Soliqua 100/33 form

Soliqua 100/33 comes as a liquid solution in prefilled, single-use pens known as SoloStar pens.

Soliqua 100/33 strength

Each Soliqua 100/33 pen contains 300 units of insulin glargine and 100 micrograms (mcg) of lixisenatide in 3 milliliters (mL) of liquid solution. This is the only available strength.

Typical dosages

Your doctor will typically start you on a low dosage of Soliqua 100/33. Then, they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Note: Regardless of the dose you’re prescribed, you should take your dose of Soliqua 100/33 within the hour before your first meal of the day.

Starting dose

The recommended starting dosage of Soliqua 100/33 is typically 15 units once per day. (This dose includes 15 units of insulin glargine and 5 mcg of lixisenatide.) This will likely be your starting dosage of Soliqua 100/33 if:

  • you’ve never used insulin or another GLP-1 receptor agonist
  • you’re currently using another GLP-1 receptor agonist
  • you’re taking less than 30 units of basal insulin per day

If you’re already taking 30 to 60 units of basal insulin per day, your doctor will likely recommend a Soliqua 100/3 starting dosage of 30 units per day. This dose includes 30 units of insulin glargine and 10 mcg of lixisenatide.

Soliqua dosage chart

Below is an example of a Soliqua 100/33 dosage chart. To view a full Soliqua 100/33 dosage chart, see the drug’s prescribing information. Micrograms is abbreviated as mcg.

Soliqua 100/33 pen dose window display*Insulin glargine doseLixisenatide dose
1515 units5 mcg
2020 units6.7 mcg
3030 units10 mcg
4040 units13.3 mcg
6060 units20 mcg

* Each Soliqua 100/33 pen contains a “dose window” where you can view the selected dose. For more information, see “How to use” below.

After starting treatment with Soliqua 100/33, you and your doctor will monitor how your blood sugar levels respond to the drug. Your doctor may increase or decrease your dose each week depending on your blood sugar levels and your blood sugar goals.

Maximum dose

The maximum dosage of Soliqua 100/33 is 60 units (60 units of insulin glargine and 20 mcg of lixisenatide) once per day.

Long-term use

Soliqua 100/33 is typically a long-term treatment. If you and your doctor determine that Soliqua 100/33 is safe and effective for you, you’ll likely take it long term.

The Soliqua 100/33 dosage your doctor prescribes will depend on several factors. These include:

  • the severity of the condition you’re using Soliqua 100/33 to treat
  • other medications you may take to treat type 2 diabetes

Other medical conditions you have may also affect your Soliqua 100/33 dosage. Talk with your doctor about the dose of Soliqua 100/33 that’s right for you.

Dosage adjustments

In some cases, your doctor may recommend dosage adjustments to your Soliqua 100/33 treatment plan. They may adjust your dose if:

  • you have a liver condition, such as hepatitis
  • you have kidney disease
  • you develop an illness or infection
  • you change your diet or exercise habits

Soliqua 100/33 comes as a liquid solution in prefilled SoloStar pens. It is given as a subcutaneous injection. Your doctor or another healthcare professional can show you how to self-inject Soliqua 100/33.

Each Soliqua 100/33 pen contains a “dose window” where you can view the dose. You’ll use a dose selector on the pen to choose the dose your doctor prescribes for you.

You’ll inject Soliqua 100/33 into one of the following areas:

  • your abdomen, at least 2 inches away from your belly button
  • your thighs
  • your upper arms

You should change the site where you inject each dose of Soliqua 100/33. This helps reduce your risk for injection site reactions, such as skin thickening or a rash. Do not inject Soliqua 100/33 into skin that is bruised, damaged, or scarred. And you should not inject into areas of the skin that are hard, scaly, or tender.

The pens do not include pen needles, and you’ll need pen needles to give your injections. You can usually buy pen needles at a pharmacy, but you may need a prescription. You can only use each pen needle once. Use a new needle for each Soliqua 100/33 dose.

If you’d like to view step-by-step instructions or a video on how to take Soliqua 100/33, visit the manufacturer’s website.

If you miss a dose of Soliqua 100/33, you should skip the missed dose and take your usual dose the next day. You should not take more than one dose at a time to try to make up for the missed dose. Doing so can increase your risk for side effects such as hypoglycemia (low blood sugar).

To help make sure you don’t miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

It’s important not to take more Soliqua 100/33 than your doctor prescribes. If you take more than your doctor prescribes, you may develop serious side effects.

Symptoms of overdose

Symptoms of Soliqua 100/33 overdose can include:

If you take more than the recommended amount of Soliqua 100/33

Call your doctor right away if you believe you’ve taken too much Soliqua 100/33. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosages in this article are typical dosages provided by the drug manufacturer. If your doctor recommends Soliqua 100/33 for you, they’ll prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you.

As with any drug, never change your dosage of Soliqua 100/33 without your doctor’s recommendation. If you have questions about your dosage, talk with your doctor.

Besides learning about dosage, you may want other information about Soliqua 100/33. These additional articles might be helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.