Sotyktu (deucravacitinib) is a brand-name drug that’s prescribed for moderate to severe plaque psoriasis in certain adults. Sotyktu comes as an oral tablet that’s typically taken once per day.

Sotyktu belongs to a drug class called tyrosine kinase 2 inhibitors. Sotyktu isn’t available in a generic version.

Keep reading for specific information about the dosage of Sotyktu, including its strength and how to take the medication. For a comprehensive look at Sotyktu, see this article.

Note: This article describes the typical dosage for Sotyktu provided by the drug’s manufacturer. When taking Sotyktu, always follow the dosage prescribed by your doctor.

Read below for details about Sotyktu’s dosage for its approved use.

Sotyktu form

Sotyktu comes as an oral tablet.

Sotyktu strength

Sotyktu comes in one strength of 6 milligrams (mg).

Typical dosage

The following information describes the dosage that’s commonly recommended in adults. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for plaque psoriasis

The typically recommended dosage for plaque psoriasis is 6 mg once per day. For more information about your specific dosage, talk with your doctor.

Note: Doctors prescribe Sotyktu for moderate to severe plaque psoriasis that may improve with other therapies. These include phototherapy (light therapy) or systemic therapy (medications that affect the whole body). (Sotyktu is a systemic therapy.)

Long-term treatment

Sotyktu is meant to be a long-term treatment. If you and your doctor determine that Sotyktu is safe and effective for you, you’ll likely take it long term.

Before you start taking Sotyktu, your doctor will discuss your treatment plan with you.

Sotyktu comes as a tablet that you swallow whole. You should not divide, crush, chew, or cut the tablet. You may take your dose with or without food.

It may be helpful to take Sotyktu around the same time each day. This helps maintain a steady level of the drug in your body so Sotyktu can work effectively.

If you have trouble swallowing tablets, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.

If you have questions about how to take Sotyktu, talk with your doctor or pharmacist.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Sotyktu in an easy-open container. They also may recommend tools that can make it easier to open bottles.

The drug’s manufacturer doesn’t state what to do for a missed dose of Sotyktu. If you miss a dose, talk with your doctor or pharmacist. They’ll be able to counsel you on your next steps.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.

It’s important that you do not take more Sotyktu than your doctor prescribes. For some medications, taking more than the recommended amount may lead to harmful effects or overdose.

If you take more than the recommended amount of Sotyktu

Call your doctor right away if you believe you’ve taken too much Sotyktu. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Below are some frequently asked questions about Sotyktu.

How long does it take for Sotyktu to start working?

Sotyktu starts to work after your first dose. Because of how the drug works, you likely won’t feel a difference in your body right away. Based on the drug’s clinical trials, it may be a few weeks before you notice your plaque psoriasis symptoms easing. Your doctor will monitor you during treatment to find out whether the drug is effective for your condition.

Talk with your doctor if you have questions about what to expect with Sotyktu treatment.

What is the recommended maximum dosage of Sotyktu?

The maximum recommended dosage of Sotyktu is 6 milligrams (mg) per day. This is the same as the typically recommended dosage. The drug’s manufacturer does not recommend dose increases or decreases during Sotyktu treatment. In clinical trials of Sotyktu, no additional benefits were seen with dosages higher than 6 mg per day. For details about Sotyktu dosages, see the “Sotyktu dosage” section above.

If you have questions or concerns about Sotyktu dosages, talk with your doctor.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Sotyktu for you, they’ll prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Sotyktu without your doctor’s recommendation. If you have questions about the dosage of Sotyktu that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Sotyktu. These additional articles might be helpful:

  • More about Sotyktu. For information about other aspects of Sotyktu, refer to this article.
  • Details about your condition. For details about your condition, see our psoriasis hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.