Takhzyro (lanadelumab-flyo) is a brand-name drug prescribed to manage hereditary angioedema attacks. It‘s available as a prefilled syringe or a single-dose injectable solution. The cost of Takhzyro with and without insurance can depend on several factors.

Takhzyro is approved by the Food and Drug Administration (FDA) to help prevent episodes of hereditary angioedema in adults and children ages 2 years and older. It belongs to a drug class called monoclonal antibodies. Takhzyro is not available in a biosimilar version.

Read on to learn about Takhzyro and cost, as well as how to save money on prescriptions. If you’d like other information about Takhzyro, refer to this article.

As with all medications, the cost of Takhzyro can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • the cost of the visit to your healthcare professional to receive doses of Takhzyro
  • whether Takhzyro has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Takhzyro will be for you, talk with your doctor, pharmacist, or insurance provider.

Insurance considerations

Below is information you may want to consider if you have insurance and receive Takhzyro.

Prior authorization. If you have insurance, your insurance company may require prior authorization before it covers Takhzyro. This means the company and your doctor will discuss Takhzyro in regard to your treatment. The insurance company will then determine whether the medication is covered. If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Takhzyro requires prior authorization.

Type of insurance coverage. Takhzyro injections may be given by you, a caregiver, or a healthcare professional. If you have insurance, the price of your Takhzyro doses may be billed through your medical coverage instead of the prescription drug portion of your insurance plan. This depends on your specific insurance plan and where you receive your Takhzyro doses, such as at your doctor’s office, an infusion clinic, or a hospital, and whether the office asks you to pick up the medication from the pharmacy first. If you have questions about this process, contact your doctor or your insurance provider.

Takhzyro contains the active ingredient lanadelumab-flyo, and it’s available only as a brand-name biologic drug. It doesn’t come in a biosimilar version. A biosimilar medication is a drug that’s similar to a brand-name biologic drug (the parent drug). Also, biosimilars tend to cost less than brand-name medications.


Biologic drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a biologic drug can sell it for up to 12 years. When the biologic drug’s patent expires, multiple manufacturers can create biosimilar versions. This marketplace competition may lead to lower costs for biosimilars. Also, because biosimilars are very similar to biologic drugs, they don’t require the same costly testing.

If you take Takhzyro long term, you may be able to lower its cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of Takhzyro. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need financial support to pay for Takhzyro, or if you need help understanding your insurance coverage, help is available. For example:

  • A program called OnePath is available for Takhzyro. For more information and to find out whether you’re eligible for support, call 866–888–0660 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Here are answers to some frequently asked questions about drug cost and Takhzyro.

How does Takhzyro’s cost compare with that of medications such as Firazyr, Berinert, Orladeyo, or Haegarda?

The price you would pay for Takhzyro versus that of Firazyr (icatibant), Berinert (C1 esterase inhibitor), Orladeyo (berotralstat), or Haegarda (C1 esterase inhibitor) depends on various factors.

For instance, the form of the drug may affect its price. Takhzyro, Firazyr, and Berinert are available as an injection. In contrast, Orladeyo is available as an oral capsule. Typically, injectable drugs cost more than capsules.

There are additional factors that can affect your prescription cost, including:

  • the length of your treatment
  • whether there are payment assistance programs for your prescribed treatment
  • whether you’re paying out of pocket or have insurance
  • whether you will self-administer your prescribed treatment

To learn more about the cost of Takhzyro compared with other treatments for your condition, talk with your doctor, pharmacist, or insurance provider (if you have one).

How much does Takhzyro cost with insurance vs. without it?

What you pay for Takhzyro if you have insurance compared to what you’d pay without it depends on several factors.

Factors that could affect what you pay for this drug without insurance include:

  • the quantity you’re prescribed (such as a 90-day or 30-day supply)
  • whether you apply and qualify for any available savings programs
  • your dosage and treatment plan
  • whether your doctor injects your medication or you or a caregiver administer the injection
  • the pharmacy you use
  • the form of the drug you’re prescribed (such as the prefilled syringe or single-dose vial)

These same factors may affect your price for Takhzyro if you have insurance. But the price you pay with insurance will also depend on:

  • your specific plan benefits
  • any prior authorization requirements you have for drug coverage

To learn more about what you’d pay for Takhzyro with or without insurance, talk with your doctor, pharmacist, or insurance provider (if you have one).

Now that you’ve learned about cost and Takhzyro, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Takhzyro. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for Takhzyro.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.