Trintellix (vortioxetine) is a brand-name tablet that’s prescribed for major depressive disorder. The cost of the drug with and without insurance can depend on several factors, such as whether Trintellix has a savings program.

Trintellix belongs to a drug class called antidepressants. Trintellix is not available in a generic version.

Read on to learn about Trintellix and cost, as well as how to save money on prescriptions. If you’d like other information about Trintellix, refer to this article.

As with all medications, the cost of Trintellix can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy you use
  • whether Trintellix has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Trintellix will be for you, talk with your doctor, pharmacist, or insurance provider.

Note: If you have insurance, your insurance company may require prior authorization before it covers Trintellix. This means the company and your doctor will discuss Trintellix in regard to your treatment. The insurance company will then determine whether the medication is covered. If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Trintellix requires prior authorization.

Here are answers to some frequently asked questions about drug cost and Trintellix.

Does Trintellix 5 mg cost less than the drug’s other strengths?

It’s possible. Trintellix is available in the following strengths: 5 milligrams (mg), 10 mg, and 20 mg. The price you’ll pay can depend on multiple factors, including your insurance coverage, the pharmacy you use, and your specific treatment plan.

For more information about the cost of Trintellix, talk with your doctor or pharmacist.

Is Trintellix covered by Medicare?

Yes, certain Medicare plans may cover Trintellix. Specifically, Medicare Part D plans cover some prescription drug costs. The exact coverage amount will depend on your specific Medicare plan.

To learn more about the cost of Trintellix with Medicare, contact your Medicare provider. You can also read about the Medicare drug list for more details about your coverage options.

Trintellix is only available as a brand-name drug. It doesn’t come in a generic version. A generic drug is an exact copy of the active drug in a brand-name medication.

Generics tend to cost less than brand-name drugs.


Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions. This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

If you take Trintellix long term, you may be able to lower its cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of Trintellix. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

Using a mail-order pharmacy

Trintellix may be available through a mail-order pharmacy. Using this type of service may help lower the drug’s cost and allow you to receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug via mail order.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need financial support to pay for Trintellix, or if you need help understanding your insurance coverage, help is available. For example:

  • The tAccess Support Program is available for Trintellix. This program offers the Trintellix Savings Card and other resources for financial assistance. For more information and to find out if you’re eligible for support, call 844‑654‑TRIN (844-654-8746) or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Now that you’ve learned about cost and Trintellix, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Trintellix. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for Trintellix.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.