Ubrelvy (ubrogepant) is a brand-name oral tablet that’s prescribed for migraine in adults. As with other drugs, Ubrelvy can cause side effects such as nausea and fatigue.

Ubrelvy can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took Ubrelvy in clinical trials:

* For more information about this side effect, see “Side effect specifics” below.

Mild side effects can occur with Ubrelvy use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to Ubrelvy’s prescribing information.

Mild side effects that have been reported with Ubrelvy include:

These side effects may be temporary, lasting a few days or weeks. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you develop a side effect while taking Ubrelvy and want to tell the FDA about it, visit MedWatch.

* For more information about this side effect, see “Side effect specifics” below.

Allergic reaction is a possible serious side effect of Ubrelvy. Allergic reaction wasn’t reported in clinical trials, but it has been reported since Ubrelvy became available for use.

There aren’t any other known serious side effects caused by this drug. See “Side effect specifics” below for details about allergic reaction.

If you develop serious side effects while taking Ubrelvy, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Ubrelvy may cause several side effects. Here are some frequently asked questions about the drug’s side effects and their answers.

Are rebound headaches a side effect of Ubrelvy?

It’s not likely.

Rebound headaches (also known as medication overuse headaches) can occur from using some migraine medications frequently. Other migraine medications, such as sumatriptan (Imitrex), can cause rebound headaches. But no one taking Ubrelvy in clinical trials reported rebound headaches as a side effect.

If you have questions about rebound headaches and your migraine treatment plan, talk with your doctor or pharmacist.

Should I expect weight gain or weight loss while taking Ubrelvy?

No, neither weight gain nor weight loss have been reported as side effects of Ubrelvy. No one taking the medication in clinical trials reported weight loss or weight gain as a side effect.

Other drugs prescribed for treating migraine have been found to cause weight changes. For example, topiramate (Topamax) may cause weight loss as a side effect. The following migraine drugs may cause weight gain, however:

If you have questions about weight changes related to your migraine treatment, talk with your doctor or pharmacist.

Does Ubrelvy cause vomiting?

It’s not likely. No one taking Ubrelvy in clinical trials reported vomiting as a side effect. Mild nausea is a possible side effect of Ubrelvy, though. See “Side effect specifics” below for more information.

If you have questions about vomiting while taking Ubrelvy, talk with your doctor or pharmacist.

Learn more about some of the side effects that Ubrelvy may cause.

Sleepiness

It’s possible to experience sleepiness as a side effect from taking Ubrelvy. This was one of the more common side effects reported by people taking the drug in clinical trials.

The 50-milligram (mg) dose of Ubrelvy may be slightly less likely to cause sleepiness compared with the 100-mg dose.

For most people who experience sleepiness from taking Ubrelvy, this side effect isn’t serious. Also, keep in mind that a migraine episode can cause you to feel sleepy.

What you can do

Avoid driving or operating machinery after taking a dose of Ubrelvy until you know how the medication will affect you. Your doctor or pharmacist may recommend avoiding other activities until you know if the drug causes sleepiness for you. They can also recommend ways to treat sleepiness or help your energy levels.

If you have sleepiness that’s severe or bothering you, talk with your doctor or pharmacist. They may recommend other treatments for your migraines.

Dry mouth

Dry mouth can be a side effect of Ubrelvy. This was rarely reported by people taking the medication in clinical trials.

Dry mouth may be slightly more likely to occur if you’re taking the 100-mg dose of Ubrelvy, compared with the 50-mg dose.

What you can do

Talk with your doctor or pharmacist if you have dry mouth while taking Ubrelvy. They can recommend ways to treat this side effect. For example, sipping water or chewing sugar-free gum may help prevent or relieve dry mouth. You can also try an over-the-counter saliva substitute.

Nausea

Nausea was the most common side effect reported by people taking Ubrelvy in clinical trials. Nausea is also a possible symptom of migraine episodes.

You may be slightly more likely to have nausea from taking the 100-mg dose of Ubrelvy compared with the 50-mg dose.

What you can do

If you experience nausea while taking Ubrelvy, talk with your doctor or pharmacist. They can recommend ways to help you manage this side effect. For example, they may have you try taking the medication with food.

If you have nausea that’s severe or is bothering you, your doctor may recommend stopping Ubrelvy and trying a different migraine drug.

Allergic reaction

As with most drugs, Ubrelvy can cause an allergic reaction in some people. Allergic reaction wasn’t reported in clinical trials, but it has been reported since Ubrelvy became available for use.

Symptoms can be mild or serious and can include:

  • skin rash
  • itching
  • flushing
  • swelling under your skin, typically in your lips, eyelids, feet, or hands
  • swelling of your mouth, tongue, or throat, which can make it hard to breathe

What you can do

For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should keep taking Ubrelvy. But if your symptoms are serious and you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Be sure to talk with your doctor about your health history before you take Ubrelvy. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. The conditions and factors to consider include:

Kidney problems. Having kidney problems, such as chronic kidney disease, can cause Ubrelvy to build up in your body. This increases your risk for side effects of the drug. Depending on how severe your kidney problems are, your doctor may prescribe a low Ubrelvy dosage for you. Or, they may recommend a different migraine treatment.

Liver problems. If you have liver problems or liver disease, Ubrelvy may build up in your body. This can increase your risk for side effects. Your doctor may prescribe a low Ubrelvy dosage if your liver problems are severe.

Taking certain medications. Ubrelvy should not be used with medications that are strong CYP3A4 inhibitors. For more information about potential interactions between other drugs you’re taking and Ubrelvy, talk with your doctor or pharmacist. You can also refer to this article about Ubrelvy’s interactions.

Allergic reaction. If you’ve ever had an allergic reaction to Ubrelvy or any of its ingredients, your doctor won’t prescribe this drug for you. Talk with your doctor about which other treatments are better choices for you.

Alcohol use with Ubrelvy

There aren’t any known interactions between drinking alcohol and using Ubrelvy.

But alcohol may worsen some side effects of Ubrelvy, such as nausea or sleepiness. And for some people, alcohol can trigger a migraine episode.

Talk with your doctor about how much alcohol, if any, is safe for you to have while taking Ubrelvy.

Pregnancy and breastfeeding while taking Ubrelvy

It’s not known whether it’s safe to take Ubrelvy while pregnant. This is because the drug’s use during pregnancy hasn’t been studied. The drug caused some harm in animal trials, but these studies don’t always predict what might happen in people. Talk with your doctor before using Ubrelvy if you’re pregnant or planning to become pregnant.

It’s also not known whether it’s safe to use Ubrelvy while breastfeeding. If you’re breastfeeding or planning to breastfeed, talk with your doctor about safe ways to feed your child.

Side effects from Ubrelvy aren’t common. And when they do occur, they’re usually mild. Most mild side effects of the drug tend to go away without medical attention.

If you’d like to learn more about Ubrelvy, talk with your doctor or pharmacist. They can help answer any questions you have about side effects from taking the drug.

Besides talking with your doctor, you can do some research on your own. These articles might help:

  • More information on Ubrelvy. For details on other aspects of Ubrelvy, refer to this article.
  • Drug comparison. To learn how Ubrelvy compares with other drugs, read the comparison articles on these medications: Imitrex and triptans.
  • Cost. If you’d like to learn about Ubrelvy and cost, see this article.
  • Dosage. For information about the dosage of Ubrelvy, view this article.
  • Interactions. To find out about Ubrelvy’s interactions, see this article.
  • Use for migraine. For details about how Ubrelvy is used for migraine, refer to this article. And for more information about migraine, see our headache and migraine hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.