Xtandi (enzalutamide) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat castration-resistant prostate cancer and a type of metastatic prostate cancer.

For more information about Xtandi’s uses, refer to this article.

Drug details

Here are some details about Xtandi:

  • Drug forms: oral capsule and oral tablet
  • Generic version: not available

Read on to learn about Xtandi and cost, as well as how to save money on prescriptions.

As with all medications, the cost of Xtandi can vary. Factors that may affect the price you’ll pay include:

  • your treatment plan
  • your insurance coverage
  • the pharmacy* you use
  • whether Xtandi has a savings program (see the “Financial and insurance assistance” section below)

To find out what the cost of Xtandi will be for you, talk with your doctor, pharmacist, or insurance provider.

Note: If you have insurance, your insurance company may require prior authorization before it covers Xtandi. This means the company and your doctor will discuss Xtandi in regard to your treatment. The insurance company will then determine whether the medication is covered. If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether Xtandi requires prior authorization.

* Xtandi prescriptions are filled only at specialty pharmacies. This is a pharmacy that has authorization to carry specialty medications. These are drugs that may be costly or require help from a healthcare professional to take them safely and effectively.

Here are answers to some frequently asked questions about drug cost and Xtandi.

Is there a copay card or manufacturer coupon available for Xtandi?

A program is available to help you manage your Xtandi copay, but there isn’t a manufacturer coupon for the drug.

If you have insurance that covers prescription drugs, you may be eligible for the Xtandi Patient Savings Program. Once enrolled, the program can help you manage your Xtandi copay. (A copay is set by your insurance policy. It’s the fee you pay for a doctor’s appointment or a prescription, while your insurance pays for the rest.) You can also call Xtandi Support Solutions at 855-898-2634 to see if you qualify for copay assistance.

If you have additional questions, talk with your doctor, pharmacist, or insurance provider.

How do the prices of Xtandi’s 40-mg strength and other strengths compare?

The cost of the 40-milligram (mg) strengths of Xtandi oral capsules and oral tablets* may vary depending on several factors. These can include whether you have insurance and the specific details of your plan’s prescription drug coverage. (For details, see the “Xtandi cost” section above.) You can contact your insurance provider to learn more.

If you don’t have insurance, talk with your doctor or pharmacist about Xtandi’s price. If you need help paying for Xtandi, see the “Financial and insurance assistance” section below.

* Xtandi oral tablets are also available in an 80-mg strength.

How can I determine Xtandi’s cost with insurance and without insurance?

Your pharmacist can help determine Xtandi’s cost with and without insurance. You can also reach out to your doctor or insurance company. The cost of medications with insurance is typically less than the cost without insurance.

What does Xtandi cost per month?

What you’ll pay for Xtandi per month can depend on a number of factors. One is whether you have insurance. Other factors include your specific insurance plan and what pharmacy you use.

You may be able to get a 3-month supply of Xtandi. To learn more, see the “Ways to reduce long-term drug costs” section below.

To determine Xtandi’s cost per month, talk with your doctor or pharmacist.

How much does Xtandi cost with Medicare?

To find out Xtandi’s cost with Medicare, you’ll first need to know whether it’s covered by Medicare. To do this, contact your specific Medicare plan provider.

If Medicare covers Xtandi, the cost may vary. This is because each plan has different coverage levels. For example, Medicare Part B doesn’t cover most prescription drugs. Medicare Part D, on the other hand, may cover your prescriptions, depending on the drug.

To learn more about Medicare, see the “Next steps” section below.

Xtandi is available only as a brand-name drug. It doesn’t come in a generic version. A generic drug is an exact copy of the active drug in a brand-name medication.

Generics tend to cost less than brand-name drugs.


Brand-name drugs can be expensive because of the research needed to test their safety and effectiveness. The manufacturer of a brand-name drug can sell it for up to 20 years. When the brand-name drug’s patent expires, multiple manufacturers can create generic versions. This marketplace competition may lead to lower costs for generics. Also, because generics contain the same active ingredients as brand-name drugs, they don’t require the same costly testing.

If you take Xtandi long term, you may be able to lower its cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of Xtandi. If approved by your insurance company, getting a 90-day supply of the drug could help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

Using a mail-order pharmacy

Xtandi is available only through a specialty mail-order pharmacy.* With mail-order service, you can receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug with this service.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

* A specialty pharmacy has authorization to carry specialty medications, such as Xtandi. These are drugs that may be costly or require help from a healthcare professional to take them safely and effectively.

If you need financial support to pay for Xtandi, or if you need help understanding your insurance coverage, help is available. For example:

  • A program called Xtandi Support Solutions is available for Xtandi. For more information and to find out if you’re eligible for support, call 855-898-2634 or visit the program website.
  • Some websites provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services. Two such websites are:

To learn more about saving money on prescriptions with or without insurance, check out this article.

Now that you’ve learned about cost and Xtandi, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to Xtandi. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you’d pay for Xtandi.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.