Zeposia (ozanimod) is a brand-name drug that’s prescribed for certain conditions, such as relapsing forms of multiple sclerosis (MS), in adults. Zeposia comes as a capsule that’s typically taken once per day.

Zeposia is approved by the Food and Drug Administration (FDA) to treat the following in adults:

Zeposia belongs to a drug class called immune modulators. Zeposia is not available in a generic version.

Keep reading for specific information about the dosage of Zeposia, including its strengths and how to take the medication. For a comprehensive look at Zeposia, see this article.

Note: This article describes typical dosages for Zeposia provided by the drug’s manufacturer. When taking Zeposia, always follow the dosage prescribed by your doctor.

This section describes the typical dosage for Zeposia. The following table summarizes Zeposia’s recommended dosage. Your doctor will determine the dosage that’s best for you.

Zeposia starting dosage: Days 1 to 4Zeposia starting dosage: Days 5 to 7Zeposia maintenance (long-term) dosage: Day 8 and on
0.23 milligrams (mg) once daily0.46 mg once daily0.92 mg once daily

Zeposia form

Zeposia comes as an oral capsule.

Zeposia strengths

Zeposia comes in three strengths: 0.23 milligrams (mg), 0.46 mg, and 0.92 mg.

Typical dosages

Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. This gradual dosing is called titration, and it’s done to lower the risk of side effects. The dose you’ll take long term is called your maintenance dose.

There is no first-dose observation required when you start taking Zeposia. First-dose observation refers to monitoring by a healthcare professional for a period after taking the first dose of a medication. This is to watch for side effects that may occur when starting treatment with certain drugs.

However, your doctor may perform several tests before you start treatment. These tests may include blood tests and an electrocardiogram (ECG). Your doctor will also review the other medications you take and the vaccines you have had recently. Talk with your doctor about your medical history and what tests you may need before starting Zeposia.

The following information describes the dosage that is commonly used or recommended. This is the same for all conditions that Zeposia treats. However, be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Zeposia dosage for ulcerative colitis

The recommended Zeposia dosage for ulcerative colitis is:

  • Days 1 to 4 of treatment: 0.23 mg once daily
  • Days 5 to 7: 0.46 mg once daily
  • Day 8 and on: 0.92 mg once daily, which is Zeposia’s recommended maintenance dosage

Zeposia dosage for multiple sclerosis and clinically isolated syndrome

The recommended Zeposia dosage for multiple sclerosis and clinically isolated syndrome is:

  • Days 1 to 4 of treatment: 0.23 mg once daily
  • Days 5 to 7: 0.46 mg once daily
  • Day 8 and on: 0.92 mg once daily, which is Zeposia’s recommended maintenance dosage

Long-term treatment

Zeposia is meant to be used as a long-term treatment. If you and your doctor determine that Zeposia is safe and effective for you, you’ll likely take it long term.

If you miss a dose of Zeposia, call your doctor or pharmacist. They’ll tell you what to do based on where you are in your treatment.

If you miss a dose within the first 2 weeks of your treatment, you may need to start at a lower dose again. Do not take two doses of Zeposia to make up for a missed dose.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

The Zeposia dosage your doctor prescribes will depend on a few factors. These include:

  • how well you tolerate Zeposia, such as any side effects you have
  • other medical conditions you have

For example, if you have mild to moderate liver damage, your dosage will likely need adjustment. In this case, your doctor may recommend a maintenance dosage of 0.92 mg once every other day instead of once per day.

You should swallow Zeposia capsules whole. Do not chew, split, or crush the capsules.

You can take Zeposia with or without food.

However, you should avoid foods containing a high amount of tyramine during Zeposia treatment. (Tyramine is a substance that forms from the breakdown of the amino acid tyrosine.) High tyramine foods include aged, fermented, cured, smoked, and pickled foods. Eating such foods while taking Zeposia may raise your blood pressure.

If you have trouble swallowing capsules, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.

Accessible drug labels and containers

If you’re having trouble reading your prescription label, talk with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Zeposia in an easy-open container. They also may recommend tools that can make it easier to open bottles.

It’s important that you do not take more Zeposia than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects or overdose.

If you take more than the recommended amount of Zeposia

Call your doctor right away if you believe you’ve taken too much Zeposia. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosage in this article is the typical dosage provided by the drug’s manufacturer. If your doctor recommends Zeposia for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you.

As with any drug, never change your dosage of Zeposia without your doctor’s recommendation. If you have questions about the dosage of Zeposia that’s right for you, talk with your doctor.

Besides learning about dosage, you may want other information about Zeposia. These additional articles might be helpful:

  • More about Zeposia: For information about other aspects of Zeposia, refer to this article.
  • Side effects: To learn about side effects of Zeposia, see this article. You can also look at the Zeposia prescribing information.
  • Drug comparison: Find out how Zeposia compares with Gilenya and Tecfidera in this article.
  • Cost: If you’d like to learn about Zeposia and cost, see this article.
  • Details about your condition: For details about multiple sclerosis (MS) or clinically isolated syndrome, you can refer to our MS hub and list of related articles. To learn more about ulcerative colitis (UC), which is a form of inflammatory bowel disease (IBD), see our IBD hub and list of UC articles.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.