Daytrana (methylphenidate) is a brand-name skin patch that’s prescribed for ADHD. Daytrana has interactions with some other drugs and certain supplements. Examples include propranolol (Inderal LA, InnoPran XL, others) and citalopram (Celexa).

Daytrana is prescribed for attention deficit hyperactivity disorder (ADHD) in children ages 6 years and older.

An interaction occurs when one substance causes another substance to have a different effect than expected.

To learn more about Daytrana’s interactions, keep reading. For additional information about Daytrana, including details about its uses, see this article.

Before your child starts treatment with Daytrana, tell their doctor and pharmacist which prescription, over-the-counter, and other medications they take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Daytrana interacts with supplements, herbs, or vitamins, see the “Daytrana and other interactions” section below.)

If you have questions about drug interactions that may affect your child, ask their doctor or pharmacist.

Here’s a table of drugs that can interact with Daytrana. Keep in mind that this table doesn’t include all drugs that may interact with Daytrana. Some of these interactions are described in detail just below in “Drug interactions in depth.”

Drug class or drug nameDrug examplesInteraction result with Daytrana
monoamine oxidase inhibitors (MAOIs)• methylene blue (Provayblue)
• linezolid (Zyvox)
• phenelzine (Nardil)
• selegiline (Emsam)
• isocarboxazid (Marplan)
can increase the risk of very high blood pressure (for details, see “When to avoid Daytrana” below)
beta-blockers• bisoprolol
• metoprolol (Lopressor, Toprol XL, others)
• propranolol (Inderal LA, InnoPran XL, others)
can make the beta-blocker less effective
calcium channel blockers (CCBs)amlodipine (Katerzia, Norvasc, others)
diltiazem (Cardizem, Tiazac, others)
verapamil (Verelan, Verelan PM)
can make the CCB less effective
tricyclic antidepressants (TCAs)amitriptyline
• imipramine
• nortriptyline (Pamelor)
can increase the risk of side effects from the TCA
selective serotonin reuptake inhibitors (SSRIs)• citalopram (Celexa)
• fluoxetine (Prozac)
• sertraline (Zoloft)
can increase the risk of side effects from the SSRI
dopamine agonists• pramipexole (Mirapex ER)
ropinirole
• rotigotine (Neupro)
can increase the risk of side effects from Daytrana or the dopamine agonist
sodium glucose cotransporter 2 (SGLT2) inhibitors• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
can make the SGLT2 inhibitor less effective
risperidone (Risperdal, Uzedy, others)can increase the risk of extrapyramidal symptoms
bupropion (Wellbutrin SR, Wellbutrin XL, others)can increase the risk of seizures
warfarin (Jantoven)can increase the risk of side effects from warfarin

In some cases, factors or conditions could prevent your child’s doctor from prescribing Daytrana due to the risk of harm. These are known as contraindications. The contraindications of Daytrana include:

Taking a monoamine oxidase inhibitor

Doctors typically will not prescribe Daytrana in combination with a type of antidepressant called a monoamine oxidase inhibitor (MAOI).

This is because an MAOI with Daytrana can increase the risk of very high blood pressure, which can be life threatening. Symptoms may include severe headache, dizziness, and confusion.

Below are a few examples of MAOIs that can interact with Daytrana:

  • methylene blue (Provayblue)
  • linezolid (Zyvox)
  • phenelzine (Nardil)
  • selegiline (Emsam)
  • isocarboxazid (Marplan)

Before your child starts treatment with Daytrana, it’s important to tell their doctor if the child takes an MAOI. Their doctor will likely stop the MAOI and wait at least 2 weeks to start Daytrana treatment.

Having had an allergic reaction to Daytrana or any of its ingredients

If your child has ever had an allergic reaction to Daytrana or any of its ingredients, their doctor will likely not prescribe Daytrana. Treatment with Daytrana could cause another allergic reaction. You can ask them about other treatments that may be better choices for your child.

Note: Before you start treatment with Daytrana, it’s important to tell your child’s doctor if these contraindications apply. They can determine whether to prescribe Daytrana.

There aren’t any known interactions between Daytrana and alcohol. However, alcohol consumption is not recommended during Daytrana treatment.

This is because Daytrana and alcohol may mask each other’s effects. This can happen because of how each works in the body. So, drinking alcohol during Daytrana treatment could make it hard to tell whether the drug is working.

That said, Daytrana is only approved for children ages 6 years and older. Alcohol consumption is not legal in the United States for people under the age of 21 years.

If you have questions about Daytrana and alcohol, talk with your child’s doctor.

Here’s a closer look at certain drug interactions of Daytrana.

Beta-blockers

Beta-blockers are prescribed to treat high blood pressure and other heart-related conditions.

Interaction result: Taking a beta-blocker during Daytrana treatment can make the beta-blocker less effective.

Interaction explained: Daytrana and beta-blockers have opposite effects on the body.

Daytrana treatment may lead to certain heart-related side effects, including high blood pressure and fast heart rate. Among other uses, beta-blockers are prescribed to help lower blood pressure and heart rate. Taking a beta-blocker with Daytrana could make the beta-blocker less effective for these conditions.

Examples of beta-blocker drugs: Here are some beta-blockers that may interact with Daytrana:

  • bisoprolol
  • metoprolol (Lopressor, Toprol XL, others)
  • propranolol (Inderal LA, InnoPran XL, others)

Steps you or your doctor may take: Before your child starts Daytrana treatment, tell their doctor if the child takes a beta-blocker. Their doctor can recommend whether it’s safe to take these medications together.

If your child’s doctor says it’s safe, they’ll check to make sure the beta-blocker is working as usual.

If you have other questions about Daytrana and beta-blockers, talk with your child’s doctor or pharmacist.

Selective serotonin reuptake inhibitors

Selective serotonin reuptake inhibitors (SSRIs) are prescribed to treat mental health conditions, including anxiety and depression.

Interaction result: Taking an SSRI during Daytrana treatment can increase the risk of side effects from the SSRI.

Interaction explained: Daytrana may slow down the activity of a specific enzyme (protein) that helps your body break down SSRIs. As a result, Daytrana can cause SSRIs to break down more slowly. This may lead to a high level of the SSRI in your body, increasing your risk of side effects from the drug.

This includes the side effect of serotonin syndrome. This condition is caused by a high level of the chemical serotonin in the body.

Examples of SSRI drugs: Here are some SSRIs that may interact with Daytrana:

  • citalopram (Celexa)
  • fluoxetine (Prozac)
  • sertraline (Zoloft)

Steps you or your doctor may take: Before your child starts Daytrana treatment, tell your child’s doctor if they take an SSRI. They can recommend whether it’s safe for your child to take these medications together.

If your child’s doctor tells you that it’s safe, they may lower your child’s SSRI dosage. Doing so can help lower your child’s risk of side effects.

If your child takes an SSRI with Daytrana, watch for symptoms of serotonin syndrome. Examples include excessive sweating, confusion, and fever. If your child has these symptoms, tell their doctor right away. However, if your child’s symptoms seem severe or life threatening, call 911 or a local emergency number.

If you have other questions about Daytrana and SSRIs, talk with your child’s doctor or pharmacist.

Bupropion

Bupropion (Wellbutrin SR, Wellbutrin XL, others) is prescribed to treat certain types of depression.

Interaction result: Taking bupropion during Daytrana treatment may increase the risk of seizures as a side effect of either drug.

Interaction explained: Both Daytrana and bupropion may cause seizures as a side effect. Taking bupropion with Daytrana may further increase the risk of seizures.

Steps you or your doctor may take: Before starting Daytrana treatment, be sure your child’s doctor knows if they’re taking bupropion. They can advise you on whether it’s safe for your child to take these medications together.

If your child’s doctor prescribes Daytrana with bupropion, they may lower your child’s bupropion dosage. Doing so can help reduce your child’s risk of seizures.

If you have other questions about Daytrana and bupropion, talk with your child’s doctor or pharmacist.

Daytrana may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Daytrana.

Daytrana interactions with supplements

Daytrana may interact with caffeine supplements. Some people take these supplements to help them stay awake.

Taking caffeine supplements during Daytrana treatment may increase the risk of certain side effects with either substance. Examples include high blood pressure and insomnia.

Before your child starts treatment with Daytrana, tell their doctor and pharmacist which supplements, herbs, and vitamins the child takes. By sharing this information with them, you may help prevent possible interactions.

If you have questions about drug interactions that may affect your child, ask their doctor or pharmacist.

Daytrana interactions with herbs

Doctors will typically recommend that your child avoid taking St. John’s wort with Daytrana. St. John’s wort is an herbal supplement that may be used to treat depression and other conditions.

Taking St. John’s wort with Daytrana can increase the risk of serotonin syndrome. This condition is caused by a high level of the chemical serotonin in the body. Symptoms may include excessive sweating, confusion, and fever.

Before your child starts Dayatrana treatment, tell the doctor if your child takes St. John’s wort. They may be able to help identify an alternative to St. John’s wort that doesn’t have this risk.

Daytrana and vitamins

There are no specific reports of vitamins interacting with Daytrana. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your child’s doctor or pharmacist before they take any vitamin product with Daytrana.

Daytrana interactions with food

Daytrana may interact with caffeine. Consuming too much caffeine while taking Daytrana can increase the risk of side effects from either substance. Examples include high blood pressure and insomnia.

A few foods and beverages that contain caffeine include chocolate, coffee, and energy drinks.

Because of this interaction, your child’s doctor will likely recommend limiting how much caffeine your child consumes during Daytrana treatment.

If you’d like to learn more about eating certain foods during treatment with Daytrana, talk with your child’s doctor.

Daytrana and vaccines

There aren’t any known interactions between Daytrana and vaccines. Talk with your child’s doctor or pharmacist to see whether they’re due for any vaccines.

Daytrana and lab tests

Daytrana isn’t known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk with your child’s doctor.

DAYTRANA INTERACTION WITH CANNABIS OR CBD

Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have been reported to interact with Daytrana.

Combining Daytrana with cannabis or cannabis products may increase the risk of side effects, including high blood pressure and fast heart rate.

Before your child starts treatment with Daytrana, tell their doctor and pharmacist about any cannabis use. By sharing this information with them, you may help prevent possible interactions.

Note: Cannabis is illegal at a federal level but is legal in many U.S. states to varying degrees.

Certain medical conditions and other factors may increase the risk of interactions with Daytrana. Before your child starts Daytrama treatment, be sure to talk with their doctor about the child’s health history. Daytrana may not be the right treatment option if your child has certain medical conditions or other factors affecting their health.

Health conditions or factors that might interact with Daytrana include:

  • Certain mental health conditions: If your child has a mental health condition, such as psychosis or bipolar disorder, tell your child’s doctor before they start Daytrana treatment. Also, tell their doctor about any family history of suicide. The risk of mental health side effects from Daytrana may be higher for people with these factors. Your child’s doctor can advise you on whether Daytrana is the right treatment option.
  • Heart problems, including high blood pressure: Before starting Daytrana treatment, tell your child’s doctor if they have high blood pressure or a heart problem. An example is irregular heart rhythm. Daytrana may cause serious heart problems in people who have these conditions. If your child has a heart problem or high blood pressure, their doctor may prescribe a treatment other than Daytrana.
  • Seizures: Daytrana may cause seizures. If your child already has seizures, their risk of this side effect may be higher than usual. Your child’s doctor can determine whether Daytrana is a safe treatment option.
  • Circulation problems: Before your child starts Daytrana treatment, tell the doctor if your child has a circulation problem. Daytrana may cause circulation problems such as Raynaud’s disease. If your child already has a circulation problem, the drug could worsen their condition. Your child’s doctor can recommend whether Daytrana treatment is safe.
  • Vitiligo: Daytrana may cause loss of skin color around the area where the patch is applied. Your child’s risk of this side effect may be greater if they have a personal or family history of vitiligo (loss of skin color). If your child has vitiligo, their doctor can advise you on whether Daytrana is the right treatment option.
  • Glaucoma: Daytrana may worsen high pressure in the eye or glaucoma. If your child has either condition, talk with their doctor about whether Daytrana is a safe treatment option.
  • Tourette syndrome or tics: If your child has Tourette syndrome or tics, talk with their doctor. Daytrana may worsen either condition. Your child’s doctor can advise you on whether Daytrana is the right treatment option.
  • Surgeries requiring anesthesia: Certain anesthetics may increase the side effects of Daytrana during surgery. Daytrana may cause high blood pressure or heart rate during surgery. If your child requires anesthesia for surgery, talk with their doctor or surgeon. They may have your child temporarily stop Daytrana before surgery.
  • Allergic reaction: If your child has had an allergic reaction to Daytrana or any of its ingredients, their doctor will likely not prescribe Daytrana. Treatment with Daytrana could cause another allergic reaction. You can ask them about other treatments that may be better choices for your child.
  • Breastfeeding: It’s not known whether Daytrana treatment is safe while breastfeeding. The drug can pass into breast milk. However, it’s not known whether the drug may cause side effects in a child who’s breastfed. To learn more about Daytrana treatment while breastfeeding, talk with your child’s doctor.
  • Pregnancy: There haven’t been enough clinical trials to determine whether Daytrana treatment is safe while pregnant. Animal studies show that the drug may cause congenital anomalies (commonly known as birth defects) or pregnancy loss. To learn more about Daytrana treatment during pregnancy, talk with your child’s doctor.
  • Risk of misuse and addiction: Daytrana has a boxed warning about the risk of misuse and addiction. This is a serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous. For details, see the boxed warning at the top of this article.
  • Substance use disorder: Doctors typically will not prescribe Daytrana for people with substance use disorder. This condition may increase the risk of misuse and addiction with Daytrana. For details, see the boxed warning at the top of this article.

Note: The Daytrana pregnancy registry collects information about pregnancy issues related to Daytrana. To learn more, call 866-961-2388 or talk with your child’s doctor.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

  • Ask the tough question: “Are you considering suicide?”
  • Listen to the person without judgment.
  • Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
  • Stay with the person until professional help arrives.
  • Try to remove any weapons, medications, or other potentially harmful objects if it’s safe to do so.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Find more links and local resources.

Was this helpful?

You can take certain steps to help prevent interactions with Daytrana. Your child’s doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

  • Tell them about any other medications your child takes, as well as any supplements, herbs, and vitamins.
  • Create a medication list, which your child’s doctor and pharmacist can help you fill out.

It’s also important to read the Daytrana label and other paperwork that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Daytrana doesn’t come with paperwork, you can ask your child’s pharmacist to print a copy. If you need help reading or understanding this information, ask your child’s doctor or pharmacist.

You can also help prevent interactions with Daytrana by applying it exactly as your child’s doctor prescribes.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.