Alcohol consumption is one of several factors that can increase the risk of esophageal cancer.
Esophageal cancer is cancer of the esophagus, which is the tube that connects the throat and stomach.
During metabolization, alcohol breaks down into a substance called acetaldehyde. This substance can irreversibly damage DNA, increasing the risk of esophageal cancer and other types of cancers.
This article describes the link between esophageal cancer and alcohol and lists some additional risk factors for this disease. It also lists the symptoms of esophageal cancer and provides information on outlook and prevention.
Esophageal cancer occurs when the cells lining the esophagus begin to grow out of control. This type of cancer begins in the inner lining of the esophagus and spreads throughout the other layers as it develops.
According to the
- Squamous cell carcinoma: This type begins in the squamous cells that line the inside of the esophagus. It most often occurs in the upper and middle sections of the esophagus.
- Adenocarcinoma: This type begins in the glandular cells that line the esophagus and produce mucus and other fluids. It most often occurs in the lower section of the esophagus, close to the stomach.
Alcohol is a chemical substance in alcoholic beverages, such as wines, beers, and distilled spirits. The percentage of alcohol differs according to the type of beverage.
The liver metabolizes alcohol with the help of an enzyme called alcohol dehydrogenase, which converts alcohol into acetaldehyde. An accumulation of acetaldehyde can cause irreversible damage to a person’s DNA, which may result in cancer.
A second enzyme called aldehyde dehydrogenase 2 (ALDH2) helps metabolize acetaldehyde into nontoxic substances.
Alcohol consumption is an important risk factor for many types of cancer. It is responsible for about
The risk of developing esophageal cancer is
The risk of esophageal cancer is also higher among individuals who consume alcohol and have an atypical form of ALDH2.
Besides alcohol consumption, some factors that can increase a person’s risk of developing esophageal cancer
- Age: The risk of esophageal cancer increases with age, with more than 85% of diagnoses occurring in people over the age of 55 years.
- Gender: Rates of esophageal cancer are higher among males than among females.
- Tobacco use: Using tobacco products significantly increases the risk of both types of esophageal cancer. Examples of tobacco products include:
- Diet: Certain diets may increase the risk of esophageal cancer, such as those high in processed meats.
- Obesity: Being overweight increases the risk of gastroesophageal reflux disease, which increases the risk of adenocarcinoma.
Medical conditions and esophageal cancer
Some medical conditions that can increase the risk of esophageal cancer
- Barrett’s esophagus: This condition occurs due to chronic acid reflux, which is where stomach acid leaks into the lower esophagus. Over time, the acid damages the inner lining of the esophagus and replaces typical squamous cells with gland cells that may further develop into adenocarcinoma.
- Plummer-Vinson (PV) syndrome: People with PV syndrome develop webs in the upper part of the esophagus. Around
1 in 10individuals with this syndrome develop esophageal squamous cell cancer, which is cancer of the lower throat.
- Achalasia: This rare swallowing disorder occurs when the muscles of the esophagus cannot contract properly, making them unable to move food down to the stomach. As a result, food can become stuck in the esophagus. Achalasia irritates the cells lining the esophagus, increasing the risk of esophageal cancer.
- Human papillomavirus (HPV) infection: HPV refers to a group of more than
100 viruses. In parts of Asia and South Africa, around one-third of people with esophageal cancer also have signs of HPV infection.
- Other cancers: People with cancer of the mouth, throat, or lung also have an increased risk of developing esophageal cancer.
According to the
Some common symptoms a person may experience during the more advanced stages of the disease include:
Early detection of esophageal cancer can help prevent the cancer from spreading, and this can improve outcomes.
If a person has a diagnosis of Barrett’s esophagus, their doctor may advise them to undergo an upper endoscopy on a
The outlook for esophageal cancer depends on whether and to what extent the cancer has spread at the time of diagnosis.
The overall 5-year survival rate for esophageal cancer is approximately
Esophageal cancer is not always preventable. However, people can follow the steps below to help reduce their risk of developing this disease:
- avoiding smoking and drinking, if applicable
- eating a nutritious diet rich in fruits and vegetables
- exercising regularly
- consulting a doctor about symptoms, such as swallowing difficulties or chronic heartburn
Esophageal cancer affects the esophagus, which is the muscular tube connecting the throat and stomach. There are two main types of esophageal cancer; squamous cell carcinoma and adenocarcinoma. Both begin in the lining of the esophagus.
Alcohol consumption is a major risk factor for various types of cancer, including esophageal cancer. This is because alcohol partially converts to acetaldehyde during metabolization. Acetaldehyde can cause irreversible damage to a person’s DNA, and these changes may lead to cancer.
Esophageal cancer is more treatable during the early stages of the disease. As such, anyone who experiences symptoms of esophageal cancer should consult a doctor promptly for a diagnosis.