Lexapro, the brand name of escitalopram, is an antidepressant. Lexapro can cause side effects ranging from moderate to severe. Several factors can influence these side effects, such as age and taking other medications.
Doctors prescribe Lexapro to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD).
Lexapro is a selective serotonin reuptake inhibitor (SSRI). SSRIs work by slowing the reabsorption of serotonin back into nerve cells, to maintain higher serotonin levels in the brain. Serotonin is a hormone that helps stabilize mood, happiness, and a sense of well-being.
People should take Lexapro as follows:
- For MDD: Adults and adolescents aged 12–17 years should take 10 milligrams (mg) of Lexapro daily, with or without food. The dosage may increase to 20 mg daily following a doctor’s recommendation.
- For GAD: Adults should take 10 mg of Lexapro daily, with or without food.
This article provides information on the side effects of Lexapro, including interactions with different drugs and when to see a doctor.
Lexapro side effects may vary among different people, but they often resolve within the first 2 weeks after use.
Children
Doctors do not recommend Lexapro for children under the age of 12 years. A study into its effects on children aged 7–11 years old found 50% experienced:
- abdominal pain
- diarrhea
- nausea
- vomiting
- increased appetite
- common cold
- dizziness
- headache
- insomnia
- blocked nose
In the above study, one participant also experienced mania while another had suicidal ideation.
Doctors may prescribe Lexapro to adolescents aged between 12–17 for the treatment of MDD. Other side effects of Lexapro in children and adolescents include:
- increased thirst
- abnormal increase in muscle movement or agitation
- nosebleeds
- difficult urination
- heavy menstruation
- slowed growth rate
- weight change
Adults
In adults, common side effects of Lexapro include:
- nausea
- sleepiness
- weakness
- dizziness
- anxiety
- trouble sleeping
- sexual problems, such as delayed ejaculation, painful erections, or difficulty with orgasms
- sweating
- shaking
- reduced appetite
- dry mouth
- constipation
- infection
According to the National Alliance on Mental Illness (NAMI), common side effects of Lexapro should improve within 2 weeks of taking the medication. However, sexual issues from taking Lexapro often do not improve.
Pregnancy
People who are pregnant or trying to conceive should consult their doctor before taking Lexapro. They should only take this medication if the potential benefits outweigh the possible risks to the unborn baby.
According to NAMI, pregnant people who take antidepressants in their second and third trimesters have a risk of their baby being born before 37 weeks, before it is fully developed.
NAMI also note that people who take SSRIs during the second half of their pregnancy slightly raise their child’s risk of developing persistent pulmonary hypertension.
Breastfeeding
People who are breastfeeding
A boxed warning is the strongest warning the Food and Drug Administration (FDA) can require a drug to have.
The boxed warning for Lexapro indicates that it may carry a risk of suicidal ideation and behavior in children, adolescents, and young adults who take it for MDD or other psychiatric conditions.
Suicidal ideation or behaviors that Lexapro can cause may occur in the first few months of taking the drug, or if the dose changes.
A person who has any sudden changes in mood, behavior, actions, thoughts, or feelings should contact their doctor immediately.
Suicide prevention
If you know someone at immediate risk of self-harm, suicide, or hurting another person:
- Ask the tough question: “Are you considering suicide?”
- Listen to the person without judgment.
- Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
- Stay with the person until professional help arrives.
- Try to remove any weapons, medications, or other potentially harmful objects.
If you or someone you know is having thoughts of suicide, a prevention hotline can help. The National Suicide Prevention Lifeline is available 24 hours per day at 800-273-8255. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 800-273-8255.
Lexapro may produce other serious side effects. A person who experiences the symptoms listed below should seek immediate medical attention. Some serious side effects of Lexapro include:
Serotonin syndrome
Serotonin syndrome, or serotonin toxicity, is a potentially life threatening condition that occurs due to an excess of serotonin in the body.
This condition can cause changes to a person’s mental state, such as agitation, hallucinations, and delirium.
Other symptoms of serotonin syndrome include:
- coma
- rapid heartbeat
- sudden change in blood pressure
- dizziness
- excessive sweating
- flushing
- hyperthermia
- tremors
- rigidity
- muscle spasms or twitching
- lack of coordination
- seizures
- nausea
- vomiting
- diarrhea
Allergies
Lexapro may cause severe allergic reactions, which can result in:
- trouble breathing
- swelling of the face, tongue, eyes, or mouth
- rash, hives, or blisters, possibly with fever or joint pain
Mania or hypomania
Lexapro can increase a person’s likelihood of a manic episode.
Symptoms of a manic episode include:
- greatly increased energy
- insomnia
- racing thoughts
- reckless behavior
- feeling overconfident
- excessive happiness or irritability
- talking more, or faster than usual
Low sodium levels in blood
Older adults who take Lexapro may be at a greater risk of experiencing low sodium levels in the blood.
Symptoms of this condition include:
- headache
- weakness
- feeling unsteady
- confusion
- memory problems
- trouble concentrating
Lexapro can trigger adverse reactions when taken with other medications.
According to NAMI, people should not take this medication within 2 weeks of taking monoamine oxidase inhibitors, another type of antidepressant.
The antipsychotic medication pimozide can also cause serious heart problems when taken with Lexapro.
Lexapro may increase a person’s chances of experiencing abnormal bleeding or bruising when taken with aspirin, blood thinners, or non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. People who take these drugs with Lexapro may experience:
- gums that bleed more easily
- nosebleeds
- gastrointestinal bleeding
- broken capillaries
- life-threatening bleeding
Lexapro may also interact with the following drugs:
- triptans
- centrally acting drugs
- alcohol
- cimetidine
- digoxin
- lithium
- celexa
- sumatriptan
- theophylline
- carbamazepine
- triazolam
- ketoconazole
- ritonavir
- metoprolol
People should talk with their doctor about any other medications they take before using Lexapro.
Lexapro can cause issues in people with the following health conditions:
- Bipolar disorder: A person with bipolar disorder is at risk of experiencing a manic episode when taking Lexapro.
- Glaucoma: People with acute closure glaucoma may experience a glaucoma attack due to the pupil dilation that occurs when taking Lexapro.
- Seizures: Lexapro can trigger seizures and increase seizure risk in a person who experiences them.
- Heart problems: Lexapro may cause a prolonged QT interval, meaning the heart takes longer to recharge between beats.
A person who wishes to stop taking Lexapro should speak to their doctor first. Stopping Lexapro too quickly may cause:
- anxiety
- irritability
- high or low mood
- feeling restless
- changes in sleeping habits
- headache
- sweating
- nausea
- dizziness
- shaking
- confusion
- feelings of being shocked by electricity
A person who takes Lexapro should contact their doctor if they have any symptoms that cause discomfort or do not clear up.
If a person notices any serious side effects or drastic changes in mood, they should seek immediate medical help.
Generally, side effects from Lexapro should clear up within 2 weeks of taking the drug.
Although some side effects can be serious, these reactions are rare. If a person has concerns about Lexapro, they should speak to their doctor.
Side effects come with many medications, so they may be impossible to avoid. However, people should make sure they do not take any medications that could interfere with Lexapro, to minimize possible side effects.
A person can also speak with a doctor about lowering their Lexapro dosage to help reduce adverse effects.
Lexapro can trigger side effects in some people. These can range from moderate to severe, although more severe side effects are rare.
A person should discuss other medications they take before starting Lexapro. They should also tell their doctor about any other health conditions.
If a person experiences serious adverse effects when taking Lexapro, they should seek medical attention immediately.