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Lyme disease, or borreliosis, is a tick-borne infectious disease that can cause symptoms such as fever, headaches, and swollen lymph nodes. Lyme disease tests may help people who believe they have contracted the infection and are available in major pharmacies, retail stores, and online.

This article explores Lyme disease and some test kits that individuals can consider buying. It also describes when a person should speak with a doctor and includes some frequently asked questions.

Lyme disease is an infection that develops from the Borrelia bacterium. According to the Centers for Disease Control and Prevention (CDC), it is the most common vector-borne disease in the United States.

The bacterium spreads to humans through the bite of a black-legged tick — also known as the deer tick — carrying the infection. These insects can only transmit the bacteria if they have been attached to the skin for 36–48 hours before transmitting the disease.

However, most people contract the infection through nymphs. These are tiny, immature ticks fewer than 2 millimeters in size and equivalent to the size of poppy seeds, making them hard to detect.

The CDC lists some symptoms people may develop up to 30 days after experiencing a tick bite. These include:

Untreated Lyme disease can spread to the joints, heart, and nervous system, causing individuals to experience:

Furthermore, the American Academy of Dermatology Association (AAD) states that even with treatment, some symptoms may become permanent. Some people also develop arthritis or confusion, or experience concentration difficulty during the months or years following the initial tick bite.

People can find many at-home Lyme disease tests online.

They typically come with instructions, and most companies require individuals to collect their samples at home and mail it to a lab for testing. The lab then issues the results; a person can access them via email or a company’s online portal.

People may also be able to speak with a company’s medical team to discuss their results and, if applicable, any next steps.

Medical News Today chooses at-home tests that meet the following criteria where possible:

  • Laboratories: MNT will choose companies that process test samples in Clinical Laboratory Improvement Amendments (CLIA)-certified labs. This means they follow state and federal regulations.
  • Budget: MNT chooses at-home tests that suit a wide range of budgets.
  • Privacy: MNT includes companies that offer robust and transparent privacy measures, such as data protection and discreet packaging.
  • Test result speed: MNT selects companies that inform customers when they will receive their test results and whether they will receive them via email, app, or phone.
  • Further support: MNT will indicate whether a company offers further support, such as a follow-up phone consultation with a doctor to discuss test results.
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Below are four Lyme disease tests a person can find online.

Please note that the writer of this article has not tried these products. All information presented is purely research-based and correct at the time of publication.

Medical News Today follows a strict product selection and vetting process. Learn more here.

Best for a quick turnaround: LetsGetChecked Lyme Disease Test

  • Sample collection: fingerprick
  • Turnaround time: 2–5 days
  • Price: $119

This kit from LetsGetChecked tests for Borrelia IgG and IgM antibodies through a fingerprick. The website states people should receive the test 5–7 days after ordering.

Learn more about the LetsGetChecked brand here.

The company requires individuals to activate the kit, so they can collect the sample and send it back using the prepaid shipping label. They can then access their results on their online account within 2–5 days.

In addition, LetsGetChecked laboratories have a CLIA certification, meaning they comply with federal certifications.


  • nursing team available to discuss results
  • free shipping
  • payment available through a health savings account (HSA) or a flexible spending account (FSA)


  • higher price stage for single-test kits
  • shipping unavailable to all countries
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Best easy-to-use option: Everlywell Lyme Disease Test

  • Sample collection type: fingerprick
  • Turnaround time: within days, but does not state when
  • Price: $109

The Everlywell Lyme Disease Test checks for a person’s exposure to any of the three strains of Borrelia bacteria. The test may suit those experiencing fatigue, headaches, or joint pain. The test offers a fingerprick sample collection.

Learn more about Everlywell here.

Once people receive their kits, they can register them online, collect their sample, and return it to the labs using the prepaid shipping labels. They can access their results through their online dashboards.


  • uses CLIA-certified labs
  • free shipping
  • accepts HSA and FSA payments
  • independent board certified physicians who review and approve tests


  • longer time to publish results
  • not available in New York
  • relatively expensive
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Best in-person test: Quest Lyme Disease Test

  • Sample collection type: blood test
  • Turnaround time: within 5 days
  • Price: $89 and a $6 physician visit fee

The Quest Lyme Disease Test is available in person. People purchase their test and book an appointment with a nearby Quest Patient Service Center, where a medical professional collects the sample.

They then receive their results through their MyQuest accounts.


  • results available online through MyQuest portal
  • the company health team will contact individuals directly if results require prompt attention


  • additional physician fee
  • no receipt for health plan reimbursement
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Best with multiple collection methods: IGeneX Lyme Disease Test

  • Sample collection type: blood or urine
  • Turnaround time: after 10 days
  • Price: $295–546, each assay costs $195

People who wish to buy a test kit from IGeneX pay a $20 deposit fee. They then complete the paperwork with their doctor to determine which tests they should use.

Afterward, an individual can collect their sample at home and mail it to IGeneX. The company then sends the results to the doctor.


  • CLIA-certified labs
  • doctors help in choosing a test kit
  • several collection methods available


  • not a true home test — doctors help clients complete the paperwork and receive their results
  • paperwork and billing systems can be complex
  • CDC does not recommend urine testing for antigens, as there is not enough evidence for their accuracy
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The table below provides a comparison between the four at-home Lyme disease tests:

Standout featuresquick turnaround of resultseasy to usefor testing in person with a doctoroffers several collection methods
Sample collection typefingerprick fingerprickblood testblood or urine
Turnaround time2–5 dayswithin days but does not state whenwithin 5 daysafter 10 days
Price$119$109$89 + physician visit fee$295–$546

At-home testing may be more convenient and discreet than a healthcare clinic or office. It may also be cheaper than paying for a visit to a physician.

However, at-home test results do not consider a person’s circumstances. For example, it does not know a person’s medical history.

In addition, not all at-home testing services connect people with a healthcare professional to discuss the results and any next steps. People who use services that do not allow them to contact healthcare professionals may misinterpret results.

It is also important to consider if an at-home test checks for the same markers as a clinical test from a physician. If a test does not screen for the same markers as a test from a healthcare professional, there is a risk of a person receiving a false negative.

At-home Lyme disease tests are unlikely to follow the CDC’s two-step testing recommendation. The organization recommends testing twice after a positive result to reduce the risk of false positives.

According to MedlinePlus, people should arrange for a Lyme disease test if they develop symptoms and have recently removed a tick.

Individuals may require multiple tests if they believe they have Lyme disease. This is because many tests check for the presence of antibodies, which may take weeks to develop.

There are several differences between at-home and in-person Lyme disease tests. A person may consider these differences before choosing which one to purchase.

At-home tests

It is simple to purchase an at-home test: A person chooses which company to buy from and waits for the company to ship the test to their home.

However, this means that a person does not always purchase a test at the recommendation of a healthcare professional. Several conditions, such as Lyme disease, have an incubation period. This means that the antibodies at-home tests screen for may not be present for several weeks.

If a person wishes to use at-home testing, they should purchase from a company that recommends when to test to ensure they do not receive a false negative.

Once a person receives the test, they collect the sample. The company that provides the test should always include clear instructions and all the tools a person needs to collect a sample, such as a blood lancet or a urine container.

It is important to collect the sample correctly. Incorrect collection may invalidate the results of the test. Once a person has collected the sample, they send it to the company’s laboratory.

Most companies give a person their test results within a week of receiving the sample. Some may offer consultations with a healthcare professional upon receiving a positive result.

However, this means those who receive a negative result but still experience Lyme disease symptoms may wonder about their next steps.

Finally, the CDC recommends two-step testing. If a person tests positive, the CDC recommends people undergo another test to ensure the results are correct. At-home tests may not recommend this process on their websites.

In-person tests

Undergoing an in-person test can be quite different from an at-home test.

Firstly, a healthcare professional will take a history and ask questions such as whether a person has been exposed to ticks. They may also consider other diagnoses before ordering Lyme disease tests, as ticks can transmit other illnesses. Doctors may order other tests alongside Lyme disease testing depending on a person’s location and presenting symptoms.

A qualified technician will take appropriate blood samples. This reduces the risk of an invalid sample.

Healthcare professionals will follow the CDC’s recommendation of two-step testing. People can also discuss positive or negative test results and any next steps.

At-home vs. in-person test comparison

The following table provides a quick overview of the differences between at-home vs. in-person testing for Lyme disease.

Where to getonlinehealthcare professional
Order processchoose a test and paya physician will take a history before ordering a test
Where to collect the sampleat home by the individualat a lab by a qualified technician
Results timewithin a week of the lab receiving the samplemay vary depending on the lab
Healthcare professional adviceonly on receipt of a positive result, and varies by companyon receipt of a positive or negative result
Follows CDC’s two-step testing recommendationunlikelyyes
Benefitsmore convenient, discreet, and may be less expensiveless chance of an invalid sample and advice on the next steps regardless of the test result
Disadvantagesmore likely to take a sample incorrectly and may not have access to a healthcare professional after receiving the test resultslikely to be more expensive

To find the right at-home Lyme disease test, a person should consider whether:

  • the at-home test measures the same levels as a clinical test from a doctor
  • test kit samples are sent to CLIA-certified laboratories
  • the company provides users access to support from medical professionals
  • the total cost of the test kit suits their budget
  • the company provides test results in a timely, private, and convenient way
  • they are confident in their ability to collect a good sample

According to the CDC, people should perform two tests for Lyme disease, and they can use the same blood sample.

They do not need to perform another test if they receive a negative result. However, if their first test is positive or indeterminate, it is best to test again.

The CDC states the overall result is only positive for Lyme disease when the first and second tests produce a positive result.

Tests detect IgM and IgG antibodies that the body produces in response to an infection. The IgM antibodies appear early in response to the exposure, while the IgG antibodies appear 4–6 weeks after the infection and can persist for years.

However, individuals may develop antibodies several weeks after exposure. Therefore, those who test before the antibodies develop can get a false negative.

False positives can occur if a person has other conditions, including:

Early diagnosis and treatment are crucial to help prevent late Lyme disease and its symptoms, including chronic Lyme arthritis and Lyme carditis.

A person should speak with a doctor if they have a tick bite or believe it has bitten them after visiting tick-prone regions.

They should also seek medical help if they experience any signs and symptoms of Lyme disease. These include:

Undetected and untreated Lyme disease can spread and affect more areas, such as the joints, heart, and nervous system. Additional symptoms may include:

Learn more about the symptoms of Lyme disease.

People who develop new symptoms despite having had Lyme disease should speak with a medical professional.

The following are commonly asked questions about Lyme disease tests.

What is the most accurate Lyme disease test?

According to the CDC, a blood test is the most accurate Lyme disease test. Some conditions may cause similar symptoms to Lyme disease. Therefore, a blood test can provide a better diagnosis than a symptom assessment.

What are the first symptoms of Lyme disease?

People with Lyme disease develop an erythema migrans rash. They can also have a fever, swollen lymph nodes, headaches, and joint pain.

How much does a Lyme disease test cost?

The Lyme disease tests listed in this article range from around $50–$600.

What is the outlook for Lyme disease?

The outlook for Lyme disease is typically manageable. Upon early diagnosis, doctors can prescribe antibiotics. Other forms of the disease may require additional treatment, but the prolonged use of antibiotics has not proven successful.

How do they test for Lyme disease?

Medical professionals analyze a blood sample and look for antibodies to test for Lyme disease. For some people, physicians may recommend collecting a sample of cerebral spinal fluid for analysis.

The two most common antibody tests are the ELISA and the Western blot.

However, it can take as long as 30 days for a person to develop antibodies for Lyme disease, so if they get tested soon after exposure, they could get a “false negative.”

Additionally, the CDC recommends two-step testing because there is also a risk of “false positive” tests, since antibodies can linger in a person’s system after the infection is gone.

How can I test myself for Lyme disease?

To self-test for Lyme disease, a person can order an at-home test kit from one of the companies online, such as the four discussed in this article. Many companies do not require a person to consult with a medical professional first.

However, note that antibodies for Lyme disease can take weeks to develop, which could result in a false negative. Additionally, the CDC recommends two-step testing to avoid false positives. Look for at-home test companies that provide access to medical professionals to help a person take proper action after testing.

What are three common signs of Lyme disease?

According to the CDC, three common signs of Lyme disease are:

  • an erythema rash that resembles a bullseye develops at the site of the tick bite in 70-80 percent of persons who get Lyme disease
  • fatigue
  • muscle and joint aches

Lyme disease is an infection that spreads through the bite of a black-legged tick. Early diagnosis and treatment are crucial in reducing the chance of complications.

People can find test kits online, many offering a fingerprick collection.

Many companies work with CLIA-certified labs and issue results within a few days. Some also have a nursing team to discuss results and further treatment with the individual if required.