Persistent depressive disorder (PDD) and major depressive disorder (MDD) are two forms of depression. Some symptoms may overlap, and doctors may use similar approaches for the diagnosis, but the causes of PDD and MDD can differ.
A key difference involves the duration of symptoms. For a doctor to diagnose PDD in an adult, symptoms must have lasted for at least
Below, learn more about the differences between major and persistent depressive disorders. We describe their symptoms, causes, treatment, and more.
PDD and MDD have very similar symptoms. A person
The symptoms of PDD
Not every PDD symptom needs to be present at the same time for a person to receive a diagnosis.
- feeling depressed or irritable
- having a poor appetite or overeating
- having insomnia or sleeping too much
- experiencing fatigue or low energy
- having low self-esteem
- having trouble concentrating or making decisions
- having feelings of hopelessness
Children and adolescents with PDD may experience irritability as a symptom instead of depression. In these cases, the symptom only needs to be present for
Those with PDD may experience difficulties in fulfilling work, school, or home responsibilities. The condition can also make socializing and enjoying hobbies difficult. It may
As with PDD, not every symptom
- having a depressed mood that lasts for most of the day
- having less interest or pleasure in most or all activities
- experiencing fatigue
- feeling worthless or guilty
- having difficulty concentrating and making decisions
- unintentionally losing or gaining a significant amount of weight
- having trouble sleeping — insomnia — or sleeping too much
- experiencing a type of restlessness called psychomotor agitation or finding it difficult to think, speak, and do other everyday things, called psychomotor impairment
- having frequent thoughts of death
Those with MDD
Social functioning can also become difficult with MDD. The person may find it hard to work, attend school, or take care of home and family responsibilities. They may withdraw from friends and activities they once enjoyed.
While some causes of MDD and PDD may be similar, there are some crucial differences.
Mood disorders have genetic and external causes. In the case of MDD, scientists
The hippocampus helps make memories, adapt to stressful situations, and process emotions. A reduction in the size of this part of the brain can affect its ability to function.
The neurotransmitters serotonin, dopamine, and norepinephrine travel through gray matter. When MDD reduces the amount of gray matter, this
Factors that increase the chances of developing MDD
- having had depressive episodes
- experiencing a stressful life event
- having a family history of MDD
- having chronic medical conditions
- having dementia
- having anxiety
- engaging in substance misuse
Research into the causes of PDD is ongoing, but
Researchers have also found that certain parts of the brain, such as the orbitofrontal cortex and the hippocampus, are smaller in people with PDD than in those without.
Other causes of PDD are genetic, environmental, and psychological. Some of these
The diagnostic processes for PDD and MDD are similar.
Doctors, including psychiatrists, use the symptoms of MDD to diagnose it.
For a doctor to recognize MDD, a person must have
The symptoms have to adversely affect a person’s social well-being, job, or other important aspects of their life.
The symptoms that doctors use to diagnose MDD are symptoms of major depressive episodes. For a doctor to recognize the disorder, a person must also have experienced at least two of these episodes separated by at least
Doctors likewise use the symptoms of PDD to diagnose the disorder.
To receive the diagnosis, a person must have
These symptoms need to adversely affect a person’s social well-being, job, or other important areas of their life.
For a person to receive a diagnosis of PDD, the symptoms cannot have been absent for
Psychiatrists and other doctors use very similar approaches to MDD and PDD treatment.
There are several treatment options for MDD.
Doctors, including psychiatrists, help determine
For mild MDD, they often recommend psychotherapy and monitoring symptoms. However, a doctor may recommend medication for a person with MDD symptoms of any severity.
Treatments for moderate MDD often include psychotherapy and medication.
- cognitive behavioral therapy (CBT)
- behavioral activation
- interpersonal psychotherapy
Medications for MDD
- selective serotonin reuptake inhibitors (SSRIs), such as sertraline (Zoloft) and citalopram (Celexa)
- serotonin-norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine (Effexor) and duloxetine (Cymbalta)
- other medications, such as bupropion (Wellbutrin) and mirtazapine (Remeron)
Medication usually starts at a low dosage, to be increased if needed. MDD symptoms could improve in as few as
Using medication and psychotherapy can be
Treatment for PDD is
- methods of psychotherapy, such as CBT
- medication, including SSRIs or SNRIs
An SSRI is
However, a number of factors go into decisions about medication. Doctors work with people to ensure that the choice and dosage of medication best suit their needs.
Below are some frequently asked questions about major and persistent depressive disorder.
Is PPD the same as MDD?
PPD is a form of depression that lasts for 2 years or more. MDD, on the other hand, is characterized by episodes of major depression that are separated by at least 2 months.
While similar and sometimes diagnosed together, PPD and MDD are two distinct conditions.
PPD diagnosis requires at least two PDD symptoms, as well as depression or irritability that has lasted for at least 2 years. MDD diagnosis requires at least five symptoms of major depression with each episode at least 2 months apart.
Can you have MDD and PPD?
A person can have both MDD and PPD. For a person to be diagnosed with both disorders, they must meet the diagnostic criteria for each.
Can I pass on my diagnosis to my children?
Research suggests that genetic factors may play a role in the development of depressive disorders. However, it is not fully known exactly how these factors work together to cause depression.
Children of a person with a depressive disorder may be at an increased risk for developing one as well. However, this does not mean they will definitely develop a depressive disorder.
There are many other factors, such as social and physical factors, that can also influence the development of depression.
PDD and MDD are two forms of depression that have similar symptoms and treatment methods.
The main difference concerns the duration of symptoms. PDD symptoms last for at least 2 years, in adults, while people with MDD experience depressive episodes that are separated by at least 2 months.
Genetic, social, and physical factors cause PDD and MDD. Various parts of the brain play important roles in the development of these disorders.
Treating PDD and MDD may involve methods of psychotherapy, such as CBT, and medications, including SSRIs and SNRIs. These may be especially effective in combination.