Multiple myeloma (MM) is a cancer that affects the plasma cells, which fight infections. As a result, having MM may increase susceptibility to infections and make people uncertain about receiving a COVID-19 vaccination. However, it is advisable to vaccinate against COVID-19, as the benefits far outweigh the concerns.
MM is a cancer of the plasma cells, which are white blood cells that fight infections by producing antibodies. The American Cancer Society notes that MM is a relatively uncommon cancer, with about 1 in 132 people in the United States developing it at some time in their life. It tends to affect older people, and most people who receive a diagnosis are aged 65 years and over.
Due to the increased risk of potential complications from COVID-19, experts strongly recommend that people with MM receive a COVID-19 vaccination. Evidence suggests that the vaccines offer benefits and only brief side effects.
However, if a person is considering a vaccine, it is advisable for them to speak with their doctor, who can help with any additional questions or concerns.
In this article, we discuss the safety and efficacy of COVID-19 vaccines for people living with MM.
As MM affects the immune system, it can cause people to become more susceptible to infections, such as SARS-CoV-2, because the abnormal plasma cells cannot effectively fight viral or bacterial infections.
As people with MM have an increased risk of severe COVID-19, the American Society of Clinical Oncology (ASCO) advises them to get a COVID-19 vaccination. Although people with MM may experience a decreased response to the vaccine, it will still likely provide benefit and reduce the risk or severity of COVID-19.
It is important that family members and friends also receive the vaccine and continue practices such as hand washing to provide the most protection for those with MM.
Due to the increased susceptibility of people with MM, many sources note that these individuals may be a higher priority for vaccination to prevent complications. This status means that they should attempt to get a vaccination as soon as it is feasible.
However, a person should discuss this with their doctor, as if they are currently receiving immunosuppressive therapy, it may be beneficial to wait to increase the likelihood of developing immunity from the vaccine.
As scientists complete more clinical trials and research on the efficacy and safety of COVID-19 vaccines, the medical community’s understanding of the optimal timing and dosing schedule will increase.
Before scheduling a vaccination, a person should talk with their primary care doctor about the shot, as well as their current treatment status. A person’s doctor is the best resource for determining when and who should get the vaccine.
The International Myeloma Foundation offers a similar sentiment, saying that a person should work with their doctor to determine whether the vaccine is the best choice for them and when they should get it. They also strongly encourage people living with MM to get the vaccine.
Although there are concerns that the vaccine may not elicit a sufficient immune response, research suggests that a single dose of a COVID-19 vaccine can trigger an immune response in about
The study adds that people with MM are likely to have some protection after one vaccine, which may improve after the second. Therefore, the timely administration of a second vaccine dose may help boost the immune response. This is similar to how booster doses help assure adequate protection against other viruses, such as seasonal influenza.
It is also worth noting that as MM is most prevalent among older adults, this may affect the immune response, as otherwise healthy older adults also have a lower immune response following vaccination. Although vaccines may have varying rates of efficacy, this
Current research from the
The vaccine can cause side effects in anyone, including those living with multiple myeloma. It is still not known whether a person living with multiple myeloma is more likely than those without the condition to experience side effects from the shot. Some possible side effects
- redness or other discoloration
- muscle pain
- Moderna, which requires two shots
- Pfizer, which requires two shots
- Johnson & Johnson, which requires one shot
Does a person need to get the same vaccine for both shots?
Until there is more research, it is not advisable for a person to receive different brands, more inoculations, or higher doses of COVID-19 vaccines. If the second dose is not currently available, a slight delay to wait for the same brand is acceptable. If availability is an issue, a person may consider an alternative brand of vaccine but should discuss this with their doctor.
When will a person with MM receive each dose?
Currently, people with MM should follow the same recommendations as other people for receiving their vaccines. For vaccines that require two shots, people should wait
A person should talk with their doctor about the ideal time for them to receive their doses. Certain therapies will require special timing of the vaccination. In some cases, a person may need to stop therapy before their first dose and then resume it after their second dose.
People living with MM may be at different points in their therapy. In some cases, a person will not be able to receive their vaccination immediately based on the treatments they are receiving.
Many treatments for MM may affect a person’s immune system. For the body to generate protective immunity following a vaccine, the immune system and immune cells, such as plasma cells, must be functioning properly. Therefore, a person may need to stop treatment temporarily to ensure that they can generate an immune response.
A person should discuss the timing of their vaccines with their doctor.
Anyone considering a flu shot should discuss this with their doctor. The doctor may want the person to space out the shots or get them around the same time. They may also advise whether to receive a flu shot on its own or alongside a COVID vaccine.
According to the
They also advise a person not to get a second dose if they experience a severe allergic reaction to the first. A person should let their doctor know if they experience a severe allergic reaction so that they are aware of the situation.
People living with MM should get their COVID-19 vaccination as soon as it is available for them to do so. However, they should talk with their doctor before getting the vaccination to make sure that it will not interfere with their current therapy or treatment.
Although the vaccine may not elicit as strong a response as it may in other people, research still suggests that it is effective and can help a person reduce their risk of severe illness, hospitalization, and death. A person should talk with their doctor if they have any concerns about receiving their vaccination.