Primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases. PLS typically develops slowly, while ALS rapidly affects mobility and can become fatal.
Neurodegenerative diseases cause neurons in the brain and spinal cord to slowly die, leading to movement problems, disability, and in severe cases, death.
PLS is a motor neuron disease that primarily affects the upper motor neurons to cause progressive weakness in the legs. This weakness can spread to the arms and other muscles as the disease progresses. The disease typically occurs during adulthood and progresses slowly.
Lou Gehrig’s disease is another name for ALS, which affects the upper and lower motor neurons. It causes various muscle problems, such as twitching, cramping, and tightness. The disease progresses quickly and can become fatal within
In this article, we will discuss the differences and similarities between ALS and PLS.
PLS and ALS are both motor neuron diseases that cause progressive neuron death. It affects motor neurons, which control voluntary movements. Damage to these neurons affects how someone controls their muscles and movement. For example, these diseases can cause muscle spasms, weakness, and stiffness.
PLS is a rare form of motor neuron disease that primarily affects the upper motor neurons. In contrast, ALS is the most common form of motor neuron disease that affects both the upper and lower motor neurons.
The main difference between PLS and ALS is how quickly the diseases progress.
PLS progresses slowly and may take years to affect mobility. However, ALS rapidly progresses to cause severe disability and death within
There could be delays in the treatment and diagnosis of PLS as the symptoms develop slowly and appear similar to other neurological conditions, such as multiple sclerosis or Parkinson’s disease. However, both conditions cause similar symptoms in the early stages.
Both diseases cause symptoms that
- muscle weakness
- muscle spasms, cramps, and stiffness
- movement and coordination problems
- problems with balance
However, the symptoms of PLS typically affect the upper body, such as the arms and hands. Conversely,
The diseases can cause severe symptoms as they progress, including:
- difficulty chewing and swallowing
- breathing problems
- an inability to maintain weight
- anxiety and depression
- difficulty speaking or forming words
These symptoms will occur much
The exact causes of PLS and ALS are still unclear. Motor neuron diseases
For example, PLS may run in families, and variations of ALS2 genes could cause the disease. The disease can also occur without a family history of the disease. Genes likely play a role in causing PLS, but it may generally be a result of other environmental factors.
Doctors diagnose PLS and ALS by assessing symptoms, neurological examinations, and diagnostic tests, such as electromyography and an MRI. The former involves using thin needles to measure muscle activity. Doctors will first rule out other conditions that might cause similar symptoms, such as multiple sclerosis.
In PLS, doctors look for evidence of upper motor neuron dysfunction without lower motor neuron problems, such as muscle stiffness or spasms in the upper body. In ALS, they will look for dysfunction in upper and lower motor neurons, such as muscle problems in the arms and legs.
Healthcare professionals will also check the person’s medical and family history for signs of disease.
There are currently no cures for PLS or ALS, but several treatments could slow their progression and help people manage their symptoms.
Doctors may prescribe medications that
Doctors may also
People with these diseases will receive various types of support alongside medication. For example, they might receive physical or occupational therapy for certain symptoms, such as muscle weakness or movement problems. Speech and language therapists can help people experiencing difficulties with speech.
PLS and ALS are types of motor neuron disease that can cause a progressive decline in neuron function. Both diseases cause problems with voluntary control of the muscles and lead to disability. ALS progresses faster than PLS and can quickly become fatal.
While PLS typically only affects the upper body, ALS affects the whole body. Both diseases share symptoms with other neurological diseases, such as multiple sclerosis. Treatment for these conditions includes a combination of medication, therapy, and lifestyle changes.