Pure CBD or CBD isolate does not contain any tetrahydrocannabinol (THC). It may help ease anxiety and improve sleep, but it can be less potent than broad- and full-spectrum CBD.

A quick look at the best pure CBD products

This article looks at some of the best pure CBD products available to purchase and how to take and choose these products. It also covers the safety and potential side effects of pure CBD and answers some frequently asked questions.

CBD terminology

CBDA compound within the C. sativa plant that does not create the high sensation individuals commonly associate with cannabis use.
THCA compound in the C. sativa plant. It is the psychoactive compound that creates the high sensation from cannabis use.
Full-spectrumA full-spectrum product will contain all of the natural compounds in the cannabis plant, including THC. However, THC levels must be no more than 0.3% to comply with Food and Drug Administration (FDA) regulation on full-spectrum CBD products.
Broad-spectrumBroad-spectrum products contain natural compounds of the cannabis plant. However, while manufacturers remove all or most of the THC in broad-spectrum CBD, it may still be present in trace amounts.
CBD isolateThis is the purest form of CBD and should contain 0% THC.
CannabinoidsThe compounds within the cannabis plant, of which there are over 120. CBD is the second richest compound in the plant after THC.
TerpenesAnother compound of the C. sativa plant, terpenes typically give plants their specific aromas. Some terpenes, such as limonene, may have specific health benefits.
Certificate of analysis (COA)Reputable manufacturers of CBD products should ensure a COA is available for inspection. A COA provides information on the third-party testing that independent labs conduct on a particular product. Sometimes, products have a scannable smartphone code directing people to the COA online.

Read more about terminology and other important CBD information here.

What is pure CBD?

Pure CBD is also called CBD isolate. During manufacturing, hemp goes through various purifying processes to remove cannabinoids, flavonoids, and terpenes. This leaves behind pure CBD in a crystal-like form that manufacturers then grind into a powder.

Pure CBD does not contain THC, which is the psychoactive compound in cannabis. This is the ingredient that can create a “high” feeling that people commonly associate with cannabis.

Companies offer pure CBD in tinctures, oils, gummies, and topical products such as balms and creams.


Although research is ongoing, CBD may have several benefits for a person’s mental and physical health.

For instance, 2019 research shows that CBD may improve anxiety and insomnia. The authors found that anxiety levels decreased in 79.2% of the 72 participants during the first month of CBD treatment. Sleep improved in 66.7% of participants in the first month but fluctuated as the study continued.

Researchers have also found that CBD may improve symptoms of post-traumatic stress disorder (PTSD). The study shows that 91% of the 11 study participants experienced decreased severity in their PTSD symptoms during 8 weeks of CBD treatment.

An overview of CBD notes that the compound has pain-relieving and anti-inflammatory effects, which may be useful for people wishing to try CBD to reduce pain.

How to take pure CBD

People may take CBD orally via:

  • oils
  • tinctures
  • gummies
  • capsules

Alternatively, people may apply CBD topically via:

  • lotions
  • ointments and salves
  • creams

Pros and cons of pure CBD

Below are some advantages and disadvantages of pure CBD.


  • Pure CBD does not contain THC.
  • It comes in a range of oral and topical products.
  • It may help with anxiety, insomnia, and PTSD.
  • It may help decrease inflammation and serve as an antioxidative.


  • Taking pure CBD may not provide the same therapeutic effects as broad- and full-spectrum CBD as it does not contain the full spectrum of flavonoids, terpenes, and cannabinoids.
  • Pure CBD may not be as potent or effective as CBD-rich cannabis extracts.
  • The Food and Drug Administration (FDA) has not approved CBD isolate for medical conditions besides certain types of epilepsy.
  • It may cause adverse reactions such as appetite and weight fluctuations, diarrhea, and fatigue.
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The best pure CBD products

Medical News Today editors have tried some of the products in this article. Reviewers may have received some products from the manufacturers for free, which does not influence their review. All opinions are their own.

Comparison of best pure CBD products

Below is a table comparing the six best pure CBD products in this article.

PriceCBD dose per servingForm
Medterra oil$39.99 to $199.9916 mg to 100 mgoil
Extract Labs$69.9966 mgoil
Soul CBD$43 to $6510 mg to 25 mggummies
Medterra capsules$49.99 to $99.9925 mg to 100 mgcapsules
Bluebird Botanicals$49.9525 mgoil

How we chose

Medical News Today’s methodology

Medical News Today chooses products that meet the following criteria:

  • Ingredients: MNT chooses products containing safe and high quality, clearly labeled ingredients. They should also confirm they are free from pesticides, heavy metals, and mold.
  • Dosage: MNT chooses products that must clearly state the CBD dosage and THC content.
  • Serving size: MNT selects products in which manufacturers recommend a dosage and how to take it.
  • Third-party labs: MNT chooses products that undergo third-party testing for contaminants by an ISO 17025-compliant laboratory.
  • Available certificate of analysis: MNT chooses companies that demonstrate transparency and share a product’s certificate of analysis (COA) after receiving its third-party lab results.
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How to choose pure CBD

People should consider the following factors when choosing pure CBD products:

  • Health claims: The FDA has only approved one CBD product — Epidiolex — for medical use. This drug treats seizures associated with two rare forms of epilepsy. As a result, health claims companies make about their products do not have FDA backing. People should not buy products that claim to cure medical conditions or injuries.
  • COAs: People should look for products with up-to-date COAs from a third-party lab. These COAs should be readily available on the company’s website or via email and clearly show whether the ingredient list matches what is actually in the product.
  • Dose: The amount of CBD and THC in each product will vary. Those new to CBD should choose lower doses and work up to get the desired effect. If side effects occur, a person should stop taking the product and speak with a doctor.
  • Ingredients: Companies will often dissolve CBD in coconut-derived MCT oil, which is unsuitable for people with coconut allergies. Buyers should read ingredient lists carefully to ensure a product does not contain allergens.
  • Price: The price of CBD products varies depending on the type of product, the potency, the ingredients, and the number of doses per product. People should consider how cost-effective the product will be with regular use.

Safety and side effects

Although CBD isolate does not contain THC, people may still find that it causes side effects. These side effects include:

People should consult a physician before taking CBD isolate, especially if they have a pre-existing condition. For instance, CBD may be unsuitable for those with a history of depression or suicidal thoughts as it can worsen these conditions and symptoms.

Anyone experiencing suicidal thoughts should speak with a qualified healthcare professional or call an emergency mental health hotline, such as the 988 Suicide and Crisis Lifeline.

Additionally, people who are pregnant or breastfeeding should speak with a healthcare professional before trying CBD of any kind.

Some of the drugs that CBD may interact with include:

Frequently asked questions about pure CBD

Yes, pure CBD, also known as CBD isolate, is available and contains only CBD, without THC or other hemp components.

Pure CBD is available in oils, gummies, lotions, and other CBD products. Some companies sell CBD isolate in a crystal form with no other ingredients.

Pure CBD may cause side effects such as tiredness, stomach problems, appetite and weight changes, difficulty sleeping, and low blood pressure. If people are new to CBD, they should start with a low dose and gradually increase it as their body adjusts to the product.

If they experience side effects, they should stop taking the product and speak with a qualified healthcare professional.

CBD isolate should not show up in a urine test as it does not contain THC. However, some pure CBD products contain 0.01% THC, which may show up on urine tests. Typically, a concentration of 50 nanograms per mL of THC or related metabolites triggers a positive test result.

Research suggests that CBD with THC is more effective than pure CBD due to the “entourage effect,” which describes how the compounds in CBD are more effective together than when people take them in isolation.


Pure CBD, which is also called CBD isolate, comes from purified hemp and is available in oils, creams, and gummies.

Pure CBD does not contain THC. This means there is less risk of psychoactive effects than with broad- and full-spectrum CBD.

However, the FDA has not approved any CBD product besides Epidiolex. As such, people should only buy products that have been through third-party testing with easily accessible COAs, and speak with a healthcare professional if they experience side effects.