Rexulti is a brand-name prescription drug. It’s FDA-approved to treat the following conditions in adults:

  • Major depressive disorder (MDD). This condition is often simply called depression. For this use, Rexulti is given in combination with an antidepressant drug.
  • Schizophrenia. With schizophrenia, you may have delusions, hallucinations, or trouble thinking or speaking. For this use, Rexulti may be used alone or with other drugs.

Rexulti contains the active drug brexpiprazole. Rexulti isn’t an antidepressant. Instead, it belongs to a class of drugs called atypical antipsychotics. (A class of drugs describes a group of medications that work in the same way.)

Rexulti comes as tablets that are taken by mouth. It’s available in the following strengths: 0.25 milligrams (mg), 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg.

Rexulti is approved for use in adults. It isn’t approved for use in children or teenagers. This is because it’s not known if the drug is safe or effective in these age groups. In addition, Rexulti can increase the risk of suicidal thoughts or behaviors in people ages 24 years and younger. (See the “FDA warnings” section above for details.)

Effectiveness

For information on Rexulti’s effectiveness in treating the conditions listed above, see the section “Rexulti uses” below.

Rexulti contains the active drug brexpiprazole. It’s available only as a brand-name medication. Rexulti doesn’t currently come in a generic form. (A generic drug is an exact copy of the active drug in a brand-name medication.)

Rexulti can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Rexulti. These lists don’t include all possible side effects.

For more information on the possible side effects of Rexulti, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to report to the FDA a side effect you’ve had with Rexulti, you can do so through MedWatch.

Mild side effects

Mild side effects of Rexulti can include:*

  • restlessness and restless legs
  • indigestion
  • headache
  • diarrhea
  • constipation
  • unusual dreams or insomnia (trouble sleeping)
  • fatigue (lack of energy)

Some of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

* This is a partial list of mild side effects from Rexulti. To learn about other mild side effects, talk with your doctor or pharmacist, or visit Rexulti’s Medication Guide.

Serious side effects

Serious side effects from Rexulti aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

  • Stroke, which occurs more often in older people using the drug. Symptoms can include:
    • numbness or weakness in your face, arms, or legs
    • confusion
    • trouble speaking
    • trouble seeing from one or both of your eyes
  • Neuroleptic malignant syndrome (a condition that can occur with certain medications when dopamine activity is blocked). Symptoms can include:
    • fever
    • confusion
    • rigid muscles
    • sweating
  • Tardive dyskinesia (uncontrolled body movements). Symptoms can include:
    • trouble controlling movements of your face or tongue
    • excessive blinking
    • waving your arms without meaning to
  • High blood sugar level. Symptoms can include:
    • feeling very thirsty or hungry
    • weakness or tiredness
    • needing to urinate more often than usual
  • Low white blood cell level. Symptoms can include:
    • frequent infections
    • fevers
  • Orthostatic hypotension (decreased blood pressure when standing up or sitting up). Symptoms can include:
    • feeling dizzy when you stand up after being seated or lying down
  • Seizures. Symptoms can include:
    • confusion
    • uncontrollable jerking movements of your arms or legs
    • loss of consciousness
  • Trouble swallowing due to spasm of your neck muscles. Symptoms can include:
    • having food get caught in your throat
    • difficulty breathing
  • Trouble with your body’s temperature regulation. Symptoms can include:
    • difficulty cooling down after exercising or being exposed to heat
  • Increased cholesterol or triglyceride levels in your blood, which usually doesn’t cause any symptoms.

Other serious side effects, explained in more detail below in “Side effect details,” include:

* Rexulti has boxed warnings regarding these risks. A boxed warning is the strongest warning required by the Food and Drug Administration (FDA). Boxed warnings alert doctors and patients about drug effects that may be dangerous.

Side effect details

You may wonder how often certain side effects occur with this drug. Here’s some detail on several of the side effects this drug may cause.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Rexulti. But it’s not known how many people taking Rexulti have had an allergic reaction to the drug.

Symptoms of a mild allergic reaction can include:

  • skin rash
  • itchiness
  • flushing (warmth and redness in your skin)

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under your skin, typically in your eyelids, lips, hands, or feet
  • swelling of your tongue, mouth, or throat
  • trouble breathing

Call your doctor right away if you have a severe allergic reaction to Rexulti. But call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.

Weight gain or weight loss

You may have changes in your weight or metabolism while you’re taking Rexulti. (Your metabolism refers to all of the chemical reactions in your body.) Below, we describe these changes in more detail.

If you’re concerned about changes in your weight or metabolism while you’re taking Rexulti, talk with your doctor. They can recommend ways to help you manage a body weight and metabolism that are healthy for you.

Weight gain

In clinical studies, 6% to 8% of people taking Rexulti for depression had weight gain. In comparison, 2% of people taking a placebo (treatment with no active drug) had weight gain. People who took Rexulti gained an average of 2.8 to 3.5 pounds (1.3 to 1.6 kilograms), depending on their dose of the drug. In comparison, people who took a placebo gained an average of 0.7 lb (0.3 kg).

Also, in clinical studies of people with schizophrenia, 3% to 4% of people taking Rexulti had weight gain. In comparison, 2% of people taking a placebo had weight gain. People who took Rexulti gained an average of 2.2 to 2.6 lb (1 to 1.2 kg), depending on their dose of the drug. In comparison, people who took a placebo gained an average of 0.44 lb (0.2 kg).

Weight loss

Some people in certain clinical studies reported losing weight while taking Rexulti. However, these people may have lost weight due to other reasons. The studies that reported this weight loss weren’t designed to show the side effects caused by Rexulti.

Metabolism changes

Weight changes could be caused by changes in your metabolism while you’re using Rexulti. If your metabolism is affected by the drug, you may also have changes in your blood sugar, cholesterol, and triglyceride levels.

Anger or other mood changes

It’s possible to have increased anger or other mood changes while you’re taking Rexulti, but these side effects aren’t common.

However, keep in mind that Rexulti can increase the risk of suicidal thoughts or behaviors, especially in people younger than 24 years of age. For more information about this risk, see the section “Suicidal thoughts or behaviors” below.

Changes in mood may cause the following symptoms:

  • acting in aggressive, angry, or violent ways
  • being easily irritated
  • feeling agitated or restless
  • acting very energized and talking excessively
  • worsening anxiety or panic attacks
  • increased insomnia (trouble sleeping)
  • having your depression worsen
  • thinking about dying or harming yourself
  • attempting suicide

If you notice changes in your mood or behavior, call your doctor right away. These changes could indicate that your depression is getting worse instead of better with Rexulti treatment. But if you have thoughts of harming yourself or attempting suicide, call 911 right away.

Insomnia or unusual dreams

You may have insomnia (trouble sleeping) or unusual dreams while you’re taking Rexulti. But these side effects are rare with the drug.

In one clinical study, insomnia was reported in 6.3% of people who took Rexulti. In this study, there weren’t any people who took a placebo (treatment with no active drug).

And in an early, small clinical study, more than 1% of people who took Rexulti had abnormal dreams. But when the drug was studied in a larger group of people, this side effect wasn’t reported. So, it’s not known for sure whether Rexulti causes abnormal dreams. And if the drug does cause this side effect, it’s not known how many people typically experience it.

If you have trouble sleeping or unusual dreams while you’re taking Rexulti, call your doctor right away. These changes could indicate that your depression is getting worse instead of better with Rexulti treatment. And if you have thoughts of harming yourself or attempting suicide, call 911 or your local emergency service right away.

Fatigue

It’s possible to feel tired or have increased fatigue (lack of energy) while you’re taking Rexulti.

In clinical studies of people with depression, 2% to 5% of people taking Rexulti had fatigue. In comparison, 2% of people taking a placebo (treatment with no active drug) had fatigue.

In clinical studies of people with schizophrenia, no one had fatigue. However, 2% to 3% of the people taking Rexulti had sedation (feeling very sleepy). In comparison, 1% of the people taking a placebo felt sedated.

If you feel tired or have fatigue while you’re taking Rexulti, talk with your doctor. They can recommend ways to help improve your energy level.

Anxiety

You may have new or worsened anxiety while you’re taking Rexulti. But keep in mind that anxiety is common in people with depression, which Rexulti is used to treat.

In clinical studies of people with depression, 2% to 4% of people taking Rexulti had anxiety. In comparison, 1% of people taking a placebo (treatment with no active drug) had anxiety. And in clinical studies of people with schizophrenia, no one had anxiety.

If you notice new or worsened anxiety with Rexulti, call your doctor right away. These changes could indicate that your depression is getting worse, instead of better, with Rexulti treatment. But if you have thoughts of harming yourself or attempting suicide, call 911 or your local emergency services right away.

Changes in sex drive or having other urges

Changes in sex drive, or experiencing other urges, may occur while you’re taking Rexulti. With these other urges, you may not be able to control impulses to do things such as gamble, have sex, go shopping, or binge eat.

It’s not known how many people taking Rexulti in clinical studies had these types of urges.

Keep in mind that if you’re taking Rexulti, you may not notice these urges happening to you. So it’s important that your family members or caregivers be aware of this possible side effect of the drug. This way, they may notice changes in your behavior and help point them out to you.

It’s also important to talk with your doctor if you have certain urges develop or worsen while you’re taking Rexulti. Your doctor may lower your dose of Rexulti, or they may switch you to a different medication.

Restlessness and restless legs

It’s possible to feel restless while taking Rexulti. This feeling of restlessness can lead to symptoms such as restless legs and tremors.

In clinical studies of people with depression:

  • 2% to 14% of people taking Rexulti had restlessness (also called akathisia)
  • up to 2% of people taking a placebo (treatment with no active drug) had akathisia
  • 2% to 5% of people taking Rexulti had tremors
  • 2% of people taking a placebo had tremors

In clinical studies of people with schizophrenia:

  • 4% to 7% of people taking Rexulti had akathisia
  • 5% of people taking a placebo had akathisia
  • 2% to 3% of people taking Rexulti had tremors
  • 1% of people taking a placebo had tremors

If you have restlessness with Rexulti, talk with your doctor. They can recommend ways to help decrease this side effect.

Increased risk of death in certain older adults

Rexulti can increase the risk of death in older people (ages 65 years or older) with psychosis that’s related to dementia (memory loss). (With psychosis, you lose touch with reality and may hear or see things that aren’t really there.) Because of this risk, Rexulti shouldn’t be given to older people to treat psychosis that’s related to dementia.

In fact, Rexulti has a boxed warning for this risk. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about a drug’s effects that may be dangerous.

In clinical studies, older people with psychosis related to dementia were given certain antipsychotics, which is the type of drug that Rexulti is. In these studies, the risk of death was increased about 1.6 to 1.7 times in older people taking an antipsychotic than it was in older people taking a placebo. (A placebo is a treatment that contains no active drug.)

It’s not known why antipsychotics, such as Rexulti, can increase the risk of death in older people with psychosis that’s related to dementia. In the studies mentioned above, death was often caused by heart problems or infections.

However, because Rexulti may be dangerous for use in older people, the drug should be avoided by older people with psychosis that’s related to dementia.

Suicidal thoughts or behaviors

Rexulti may increase the risk of suicidal thoughts or behaviors in some people. Specifically, this risk is increased in people ages 24 years and younger who take Rexulti.

People with a higher risk of suicidal thoughts or behaviors are those with a history of depression or other mental disorders. These other mental disorders may include bipolar disorder, which can cause both depression and mania (periods of excitement or euphoria).

In fact, Rexulti has a boxed warning for the risk of suicidal thoughts or behaviors in people of this age group. Boxed warnings are the most serious warnings from the Food and Drug Administration (FDA). These warnings alert doctors and patients about a drug’s effects that may be dangerous.

Clinical studies

In clinical studies of Rexulti, no one attempted suicide. But this risk is possible with any drug that’s used to treat depression.

Other clinical studies looked at drugs other than Rexulti that are used to treat depression. (This included selective serotonin reuptake inhibitors [SSRIs] and other classes of antidepressant drugs. Classes of drugs describe groups of medications that work in the same way.)

In these studies, people younger than 24 years of age had suicidal thoughts and suicidal behaviors more often than did people older than 24 years of age. For example, compared with people taking a placebo (treatment with no active drug), for every 1,000 people in the study:

  • 14 more people younger than 18 years of age who took a drug for depression had suicidal thoughts or behaviors
  • 5 more people ages 18 to 24 years who took a drug for depression had suicidal thoughts or behaviors

In the studies, the trend seen in older adults was opposite of the one seen in younger adults. For example, people over 25 years of age who took a drug for depression had fewer suicidal thoughts and behaviors compared with those who took a placebo.

If you have thoughts of harming yourself or attempting suicide, call your doctor right away or call 911.

The Rexulti dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Rexulti to treat
  • your age
  • other medical conditions you may have
  • other medications you may take
  • your body’s ability to metabolize (break down) certain medications

Typically, your doctor will start you on a low dosage of Rexulti. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. Your dosage range for Rexulti will depend on the above factors and how well you respond to your medication.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Rexulti comes as tablets that are taken by mouth. It’s available in the following strengths: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg.

Dosage for depression

For depression, Rexulti is used only as an adjuvant treatment. This means that Rexulti is taken with other drugs used to treat depression. It’s not used alone for this condition.

Usually, for depression, your doctor will start you at a low daily dose of Rexulti. Examples of starting dosages of Rexulti for depression are:

  • 0.5 mg taken once daily
  • 1 mg taken once daily

After 1 to 2 weeks of therapy, your doctor will likely increase your Rexulti dosage to 2 mg daily. And they’ll see how well your condition responds to the drug.

If your doctor feels that you need a higher dosage of Rexulti, they may increase your dosage to 3 mg each day. This is the maximum dosage of Rexulti that’s approved for depression treatment. But if you felt better taking 1 mg instead of 2 mg daily, your doctor may decrease your dosage back to 1 mg each day.

Dosage for schizophrenia

For schizophrenia, the typical starting dosage of Rexulti is 1 mg taken once each day. This starting dosage is taken for the first 4 days of treatment.

Then on days 5 through 7 of therapy, your doctor will increase your dosage to 2 mg once daily. And on day 8 of treatment, your doctor will likely have you begin taking 4 mg of Rexulti daily. This is the maximum dosage of Rexulti that’s approved for schizophrenia treatment.

What if I miss a dose?

If you miss a dose of Rexulti, take the missed dose as soon as you remember. But if it’s almost time for your next scheduled dose, just skip the missed dose. Then take your next dose at the regular time. Don’t double-up on your dose of Rexulti by taking two doses at once.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Rexulti is meant to be used as a long-term treatment. If you and your doctor determine that Rexulti is safe and effective for you, you’ll likely take it long term.

Other drugs are available that can treat your condition. Some may be a better fit for you than others. If you’re interested in finding an alternative to Rexulti, talk with your doctor. They can tell you about other medications that may work well for you.

Note: Some of the drugs listed below are used off-label to treat these specific conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.

Alternatives for adjuvant treatment of depression

Examples of drugs other than Rexulti that may be used as adjuvant treatment* for depression include:

* An adjuvant treatment is one that’s used in addition to other drugs to treat a condition. As an adjuvant treatment for depression, Rexulti is used with other drugs. It isn’t used alone to treat depression.

Alternatives for schizophrenia

Examples of other drugs that may be used to treat schizophrenia include:

  • chlorpromazine
  • haloperidol (Haldol)
  • clozapine (Clozaril)
  • perphenazine
  • risperidone (Risperdal)
  • quetiapine (Seroquel)
  • ziprasidone (Geodon)
  • aripiprazole (Abilify)
  • paliperidone (Invega)
  • asenapine (Saphris)
  • iloperidone (Fanapt)
  • lurasidone (Latuda)

You may wonder how Rexulti compares with other medications that are prescribed for similar uses. Here we look at how Rexulti and Abilify are alike and different.

Ingredients

Rexulti contains the active drug brexpiprazole, while Abilify contains the active drug aripiprazole. Both of these medications belong to a class of drugs called atypical antipsychotics. (A class of drugs describes a group of medications that work in the same way.)

Uses

Both Rexulti and Ability are approved to treat the following conditions:

  • Major depressive disorder (MDD). This condition is often simply called depression. For this use, Rexulti and Abilify are given in combination with an antidepressant drug. Rexulti and Abilify aren’t used on their own to treat MDD.
  • Schizophrenia. For this use, Rexulti and Abilify may be used on their own or with other drugs.

In addition, Abilify is approved to treat the following conditions:

While Rexulti is only approved for use in adults, Abilify can be used in children and teenagers, as well as adults. However, the specific age ranges that Abilify is approved for use in varies based on the condition being treated.

Drug forms and administration

Rexulti comes as tablets that are taken by mouth. It should be taken once each day, either with or without food.

Abilify comes in the following forms:

  • tablets that are swallowed by mouth
  • tablets that dissolve in your mouth (orally disintegrating tablets)
  • liquid solution that’s swallowed by mouth
  • solution that’s given as an intramuscular injection (an injection into your muscle)

How often you’ll take Abilify depends on the form of the drug that your doctor prescribes for you.

Side effects and risks

Rexulti and Abilify are both atypical antipsychotics. Therefore, these medications can cause very similar side effects, but some different ones as well. Below are examples of these side effects.

Mild side effects

These lists contain up to 10 of the most common mild side effects that can occur with Rexulti, with Abilify, or with both drugs (when taken individually).

  • Can occur with Rexulti:
    • diarrhea
  • Can occur with Abilify:
    • nausea or vomiting
    • blurred vision
    • upper respiratory infection, such as the common cold
    • dizziness
  • Can occur with both Rexulti and Abilify:
    • constipation
    • headache
    • feeling restless
    • unusual dreams or insomnia (trouble sleeping)
    • fatigue (lack of energy)

Serious side effects

These lists contain examples of serious side effects that can occur with Rexulti, with Abilify, or with both drugs (when taken individually).

* Both Rexulti and Abilify have boxed warnings regarding these risks. A boxed warning is the strongest warning required by the Food and Drug Administration (FDA). Boxed warnings alert doctors and patients about drug effects that may be dangerous.

Effectiveness

Rexulti and Abilify have different approved uses, but they’re approved for use in the treatment for MDD. (For this use, Rexulti and Abilify are given as adjunct treatment with other medications for the condition.) And Rexulti and Abilify are also both used to treat schizophrenia.

These drugs haven’t been directly compared in clinical studies. But studies have found both Rexulti and Abilify to be effective for their approved uses.

Costs

According to estimates on GoodRx.com, Rexulti generally costs more than Abilify. The actual price you’ll pay for either drug depends on your insurance plan, your location, and the pharmacy you use.

Rexulti is a brand-name drug, and there currently isn’t a generic form of Rexulti available. However, there is a generic form of Abilify available that’s called aripiprazole. Generic medications usually cost less than brand-name medications do.

You may wonder how Rexulti compares with other medications that are prescribed for similar uses. Here we look at how Rexulti and Latuda are alike and different.

Ingredients

Rexulti contains the active drug brexpiprazole, while Latuda contains the active drug lurasidone hydrochloride. Both of these medications belong to a class of drugs called atypical antipsychotics. (A class of drugs describes a group of medications that work in the same way.)

Uses

Both Rexulti and Latuda are approved to treat schizophrenia. Rexulti can be prescribed for adults with this condition. But Latuda is approved for this use in both teenagers and adults. For schizophrenia, Rexulti and Abilify can be used on their own or with other drugs.

Rexulti is also approved for use in adults with major depressive disorder (MDD), which is also simply called depression. For this use, Rexulti is given with other medications used to treat depression. Rexulti isn’t approved for use on its own for this condition.

In addition to treating schizophrenia, Latuda is approved to treat bipolar depression. The drug can be prescribed for adults and teenagers with this condition. And it may be used either by itself or with other drugs.

Drug forms and administration

Rexulti comes as tablets that are taken by mouth. It should be taken once each day, either with or without food.

Latuda comes as tablets that are taken by mouth. It should be taken once each day with food that contains at least 350 calories.

Side effects and risks

Rexulti and Latuda both contain atypical antipsychotics. Therefore, these medications can cause very similar side effects, but some different ones as well. Below are examples of these side effects.

Mild side effects

These lists contain up to 10 of the most common mild side effects that can occur with Rexulti, with Latuda, or with both drugs (when taken individually).

  • Can occur with Rexulti:
    • diarrhea
    • constipation
    • headache
  • Can occur with Latuda:
    • feeling sleepy or drowsy
    • tremor
    • runny nose
    • vomiting
  • Can occur with both Rexulti and Latuda:
    • feeling restless
    • unusual dreams or insomnia (trouble sleeping)
    • fatigue (lack of energy)

Serious side effects

These lists contain examples of serious side effects that can occur with Rexulti, with Latuda, or with both drugs (when taken individually).

* Both Rexulti and Latuda have boxed warnings regarding these risks. A boxed warning is the strongest warning required by the Food and Drug Administration (FDA). Boxed warnings alert doctors and patients about drug effects that may be dangerous.

Effectiveness

Rexulti and Latuda have different approved uses, but they’re both used to treat schizophrenia in adults. Latuda is also approved to treat schizophrenia in teenagers.

These drugs haven’t been directly compared in clinical studies. But separate studies have found both Rexulti and Latuda to be effective for their approved uses.

Costs

According to estimates on GoodRx.com, Rexulti and Latuda generally cost about the same. The actual price you’ll pay for either drug depends on your insurance plan, your location, and the pharmacy you use.

Rexulti and Latuda are both brand-name drugs. There isn’t a generic form of Rexulti available. A generic form of Latuda, called lurasidone, has been approved for use. But it’s not yet available for purchase in pharmacies.

Generic drugs generally cost less than brand-name drugs do.

The Food and Drug Administration (FDA) approves prescription drugs such as Rexulti to treat certain conditions. Rexulti may also be used off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.

Rexulti for depression

Rexulti is approved as an adjuvant treatment for major depressive disorder (MDD), which is also simply called depression. As an adjuvant treatment, Rexulti is used with other medications for depression. It’s not used alone for this condition. Rexulti is approved for use in adults with MDD.

With depression, you may have intense feelings of sadness, loss, lack of caring, or anger. And your symptoms may interfere with your everyday life.

A variety of treatments for depression are available, including cognitive therapy and medications. But it’s important to note that only about 33% of people with depression have improvement in their symptoms by taking just one antidepressant. Because of this, doctors often prescribe several antidepressants, and sometimes other types of drugs, to help relieve depression symptoms.

Rexulti is an atypical antipsychotic. It’s not an antidepressant, but it can be used in combination with antidepressants to treat MDD.

Effectiveness for depression

Rexulti was studied in two clinical trials of people with depression. People included in this study weren’t having improvement in depression symptoms with their current antidepressant treatment. During the study, people continued taking their current antidepressant. About half of the people also took Rexulti, while about half of them also took a placebo (treatment with no active drug).

Researchers assessed people’s depression symptoms by giving them a test called the Montgomery-Asberg Depression Rating Scale (MADRS). This test asks questions about feelings of sadness and tension, sleep habits, and appetite. It also asks questions about concentration. A higher test score indicates worse depression than a lower score does.

In the study, after 6 weeks of treatment:

  • people who took Rexulti 1 mg daily had their MADRS test score lowered by 7.6 points
  • people who took Rexulti 2 mg daily had their MADRS test score lowered by 8.4 points
  • people who took Rexulti 3 mg daily had their MADRS test score lowered by 8.3 points
  • people who took a placebo had their MADRS score lowered by 5.2 to 6.3 points

Rexulti for schizophrenia

Rexulti is approved to treat schizophrenia in adults. This condition is a mental disorder that has an unknown cause. It usually starts to affect people during either their teenage years or early adulthood.

Symptoms of schizophrenia can be split into the following three categories:

  • Positive. These symptoms can often be described as losing touch with reality. They may include having intrusive thoughts or hallucinations (hearing or seeing things that aren’t there). Positive symptoms may also include having delusions (believing things that aren’t true).
  • Negative. These symptoms can often be described as changes in your normal behavior or emotions. They may include having an absence of emotions or not enjoying everyday pleasures. Negative symptoms may also include not speaking as often as usual.
  • Cognitive and emotional. These symptoms can often be described as changes in your memory or way of thinking. They may include having trouble focusing, paying attention, or remembering things. Symptoms may also include having difficulty understanding information.

It’s not known for sure what causes schizophrenia. But we do know that genetics, environment, and brain chemicals could play a role. It’s also not known exactly how Rexulti treats schizophrenia. But Rexulti, which is an antipsychotic, is thought to help regulate your mood.

Effectiveness for schizophrenia

Rexulti was studied in two clinical trials of people with schizophrenia. People in the studies took either Rexulti or a placebo (treatment with no active drug). The researchers assessed people’s schizophrenia symptoms by giving them a test called the Positive and Negative Syndrome Scale (PANSS).

Schizophrenia symptoms assessed on the PANSS include hallucinations, delusions, and being unable to feel pleasure. A higher PANSS score indicates more severe schizophrenia than a lower score indicates.

In both of these studies, after 6 weeks of treatment:

  • people who took Rexulti 2 mg daily had their PANSS score lowered by 16.6 to 20.7 points
  • people who took Rexulti 4 mg daily had their PANSS score lowered by 19.7 to 20 points
  • people who took a placebo had their PANSS score lowered by 12 to 13.5 points

Rexulti for other conditions

In addition to the uses listed above, Rexulti may be used off-label for other purposes. Off-label drug use is when a drug that’s approved for one use is used for a different one that’s not approved. And you may wonder if Rexulti is used for certain other conditions. Below is information on other possible uses for Rexulti.

Rexulti for depression with anxiety (off-label use)

Rexulti isn’t approved to treat anxiety. But sometimes it’s used off-label to treat depression in people who also have symptoms of anxiety.

One study looked at using Rexulti for depression in people with anxiety. For 6 weeks, people were given either Rexulti or a placebo (treatment with no active drug). Their depression and anxiety symptoms were measured using questionnaires and other tests. People who took Rexulti 2 mg or 3 mg daily had reduced symptoms of anxiety compared with those taking a placebo.

If you have questions about using Rexulti for depression with anxiety, talk with your doctor. They can recommend whether this drug is appropriate for you. And they can advise what dosage would work best for your treatment.

Rexulti for bipolar disorder (off-label use)

Rexulti isn’t approved to treat bipolar disorder. But sometimes the drug is used off-label for this condition.

One study looked at using Rexulti in adults with bipolar disorder during episodes of depression. The people’s symptoms of depression and mania were evaluated using tests and questionnaires. (Depression and mania are the two key symptoms of bipolar disorder.)

The study found that Rexulti was effective in reducing people’s depressive symptoms. But the drug didn’t have much of an effect on their manic symptoms.

If you have questions about using Rexulti for bipolar disorder, talk with your doctor. They can recommend whether this drug is a good treatment option for you.

Rexulti for autism (under study)

Rexulti isn’t approved to treat autism. But the drug is currently being studied as a possible treatment for irritability that’s related to autism. This study is being done in children and teenagers between the ages of 5 and 17 years.

In the study, some children are taking Rexulti, while other children are taking a placebo (treatment with no active drug). The study will track the children’s irritability over the course of 8 weeks.

Keep in mind that Rexulti is currently only approved for use in adults. It isn’t approved for use in children and teenagers. It’s not known whether the drug is safe or effective in people younger than 18 years of age.

In addition, Rexulti has a boxed warning that states it can increase the risk of suicidal thoughts or behaviors in people ages 24 years and younger. A boxed warning is the strongest warning required by the FDA. Boxed warnings alert doctors and patients about a drug’s effects that may be dangerous.

If you have questions about using Rexulti to treat autism, talk with your doctor. They can advise whether this drug is a good treatment option for you.

Rexulti for borderline personality disorder (under study)

Rexulti isn’t approved to treat borderline personality disorder. But the drug is currently being studied as a possible treatment for this condition.

One study is comparing Rexulti to that of a placebo (treatment with no active drug). This study is looking at adults with borderline personality disorder who have mood instability, impulsive behavior, and trouble with relationships. The study will track their symptoms over a period of 13 weeks.

If you have questions about using Rexulti for borderline personality disorder, talk with your doctor. They can recommend whether this is a good treatment option for you.

Rexulti and children

Rexulti isn’t FDA-approved for use in children or teenagers. It’s not known whether Rexulti is safe or effective for use in people younger than 18 years of age.

In addition, Rexulti has a boxed warning that states it can increase the risk of suicidal thoughts or behaviors in people ages 24 years and younger. A boxed warning is the strongest warning required by the FDA. Boxed warnings alert doctors and patients about a drug’s effects that may be dangerous.

When used to treat major depressive disorder (MDD), Rexulti is only approved for use in combination with an antidepressant drug. (MDD is also simply called depression.) But for schizophrenia treatment, which is Rexulti’s other approved use, Rexulti can be taken alone.

In clinical studies of people with depression, Rexulti had to be taken with an antidepressant drug. In fact, people had to take their antidepressant for at least 8 weeks before adding Rexulti to their treatment regimen.

Examples of other drugs that may be used along with Rexulti for depression include:

If you have questions about which other drugs you may need to use with Rexulti, talk with your doctor. They can recommend a treatment plan that’s right for you.

You shouldn’t stop taking Rexulti “cold turkey” (abruptly) without first talking with your doctor. If you would like to stop taking this drug, your doctor will recommend a plan for you to taper off of Rexulti. Tapering off of the drug is a safer way to stop using it than abruptly stopping.

If you stop Rexulti treatment abruptly, you could have discontinuation syndrome and withdrawal symptoms. In clinical studies, people taking Rexulti didn’t have withdrawal symptoms when they stopped taking the drug. However, there have been reports of withdrawal symptoms in people who took other atypical antipsychotics that are similar to Rexulti, such as aripiprazole (Abilify).

With certain drugs, your body may become dependent on the drugs. (With dependence, your body needs a drug in order to feel normal.) And if you abruptly stop taking a drug that your body is dependent upon, you may have withdrawal symptoms.

Symptoms that have happened in people who abruptly stopped taking atypical antipsychotics have included:

  • abnormal or uncontrollable movements in certain parts of your body
  • having trouble staying still
  • nausea and vomiting
  • headache
  • insomnia (trouble sleeping)
  • increased heart rate
  • anxiety
  • blurred vision
  • sudden return of psychosis

So, it’s possible that you could have withdrawal symptoms if you abruptly stop taking Rexulti. Because of this risk, you should avoid abruptly stopping Rexulti treatment.

If you want to stop taking Rexulti, talk with your doctor. They can recommend safe and effective ways to stop treatment that will reduce your risk of withdrawal symptoms.

Rexulti contains the active drug brexpiprazole. It belongs to a class of drugs called atypical antipsychotics. (A class of drugs describes a group of medications that work in the same way.)

Rexulti is approved to treat the following conditions:

  • Major depressive disorder (MDD). This condition is often simply called depression. For this use, Rexulti is given in combination with an antidepressant drug. Rexulti isn’t used on its own to treat MDD.
  • Schizophrenia. With schizophrenia, you may have delusions, hallucinations, or trouble thinking or speaking. For this use, Rexulti may be used on its own or with other drugs.

It’s not known exactly know how Rexulti works to treat these conditions. But it’s believed that the drug binds to certain receptors (attachment sites) in your brain. The receptors affected by Rexulti usually respond to the brain chemicals serotonin and dopamine.

Serotonin and dopamine are responsible for regulating your moods. These brain chemicals are thought to be unbalanced in people with disorders such as depression and schizophrenia.

By interacting with receptors in your brain for these chemicals, Rexulti is thought to help balance serotonin and dopamine levels. This may be how Rexulti treats depression and schizophrenia.

How long does it take for Rexulti to work?

The length of time it takes for Rexulti to work will vary from person to person. And it very much depends on the severity of the condition you’re using Rexulti to treat.

In clinical studies, people who took Rexulti for depression had some improvement in their symptoms in as little as 1 week after starting the drug. But Rexulti’s full effects weren’t seen until around 5 weeks of treatment.

How long does Rexulti stay in your system?

Rexulti may stay in your system for about 18 to 19 days, which is a little less than 3 weeks.

It’s not known whether it’s safe to consume alcohol while you’re taking Rexulti.

But keep in mind that excessive alcohol intake can cause liver damage. And in people with liver damage, Rexulti can build up and cause increased side effects.

If you’re taking Rexulti, talk with your doctor before drinking alcohol. They can recommend whether it’s safe for you do so.

Here are answers to some frequently asked questions about Rexulti.

Will Rexulti make me feel high?

No, Rexulti won’t make you feel high. While it’s not known exactly know how Rexulti works, it’s thought that the drug binds to certain receptors (attachment sites) in your brain. These receptors usually respond to the brain chemicals serotonin and dopamine.

Serotonin and dopamine are responsible for regulating your moods. But they’re thought to be unbalanced in people with certain disorders. These disorders include depression and schizophrenia, which Rexulti is approved to treat.

By affecting these brain receptors, Rexulti is thought to help balance serotonin and dopamine levels. This is how the drug may work to treat depression and schizophrenia. But Rexulti’s effect on your brain shouldn’t make you feel high.

Is Rexulti an SSRI?

No, Rexulti isn’t a selective serotonin reuptake inhibitor (SSRI). SSRIs are a class of antidepressants that are used for a variety of medical conditions, including depression. (A class of drugs describes a group of medications that work in the same way.)

Instead, Rexulti contains the drug brexpiprazole, which is an atypical antipsychotic. To learn how Rexulti works, see the section above called “How Rexulti works.”

Keep in mind that when used to treat depression, Rexulti is approved for use in combination with an antidepressant. It’s not used alone for this condition. In some cases, your doctor may recommend that you take an SSRI with Rexulti to treat your depression.

But when Rexulti is used to treat schizophrenia, its other approved use, the drug can be taken alone.

Which drug class does Rexulti belong to?

Rexulti contains the active drug brexpiprazole. It belongs to a class of drugs called atypical antipsychotics. (A class of drugs describes a group of medications that work in the same way.)

To learn how Rexulti works, see the section “How Rexulti works” above.

Is Rexulti used to treat ADHD?

No, Rexulti isn’t approved to treat attention deficit hyperactivity disorder (ADHD).

Instead, Rexulti is approved to treat major depressive disorder (MDD), which is also simply called depression. (For this condition, Rexulti is approved for use in combination with an antidepressant.) In addition, Rexulti is also approved to treat schizophrenia.

Rexulti contains the active drug brexpiprazole, which belongs to a class of drugs called atypical antipsychotics. (A class of drugs describes a group of medications that work in the same way.)

Other medications, called stimulants, are usually given to treat ADHD. Examples of stimulants that are approved to treat ADHD include:

  • amphetamine/dextroamphetamine (Adderall)
  • lisdexamfetamine dimesylate (Vyvanse)

If you have questions about treatment options for ADHD, talk with your doctor.

Do side effects of Rexulti go away?

Yes, some side effects of Rexulti may go away as you continue with treatment. Examples of these side effects include:

However, other side effects of Rexulti may last as long as you’re taking the drug. For example, weight gain and restlessness may continue long term while you’re using Rexulti.

For more information about the side effects that Rexulti may cause, see the section “Rexulti side effects” above.

Will I have sun sensitivity while I’m taking Rexulti?

No, Rexulti doesn’t increase your sensitivity to sunlight.

A 2009 study showed that some people reported having sun sensitivity when taking selective serotonin reuptake inhibitors (SSRIs) to treat depression. (SSRIs are a group of drugs used to treat depression. Rexulti belongs to a different group of drugs called atypical antipsychotics.) But sun sensitivity hasn’t been reported with Rexulti use.

However, Rexulti can make it more difficult for your body to regulate its temperature. This means that after you exercise or you’re exposed to heat from the sun, it may be more difficult than usual for your body to cool down. But Rexulti doesn’t increase your skin’s sensitivity to sunlight or your risk of sunburn or skin irritation.

If you’re concerned about sun sensitivity while you’re using Rexulti, talk with your doctor.

Don’t use more Rexulti than your doctor recommends. For some drugs, doing so may lead to unwanted side effects or overdose.

What to do in case you’ve taken too much Rexulti

If you think you’ve taken too much of this drug, call your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

You should take Rexulti according to your doctor’s or healthcare provider’s instructions.

Rexulti comes as tablets that are taken by mouth once each day.

When to take

The manufacturer of Rexulti hasn’t stated a time of day that’s best to take their drug. You can take Rexulti once daily at any time of the day. (Unless your doctor recommends otherwise.)

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Taking Rexulti with food

You can take Rexulti with food, or alone on an empty stomach.

Can Rexulti be crushed, split, or chewed?

Rexulti tablets should be swallowed whole. According to the manufacturer, they shouldn’t be cut in half, crushed, or chewed.

If you have trouble swallowing pills, talk with your doctor or pharmacist if there are ways to help make taking Rexulti easier for you.

Rexulti can interact with several other medications. It can also interact with certain supplements as well as certain foods.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Rexulti and other medications

Rexulti is broken down in your body by a set of enzymes (certain proteins) that also break down other medications. If you take Rexulti with certain other drugs, the enzymes may not be able to fully break down either Rexulti or the other drugs. And this can affect your levels of either Rexulti or the other drugs.

Below, we describe these possible interactions in more detail. But keep in mind that this isn’t a complete list of all the medications that can interact with Rexulti.

Before taking Rexulti, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Rexulti and drugs that increase the level of Rexulti in your body

Some drugs can increase the level of Rexulti in your body. If these drugs are taken with Rexulti, your doctor may lower your dosage of Rexulti. This helps to keep safe levels of Rexulti in your body.

Examples of drugs that may increase your Rexulti level include:

  • certain drugs used for mood disorders, such as:
  • certain drugs used to treat fungal infections, such as:
    • itraconazole (Sporanox)
  • certain drugs used to treat bacterial infections, such as:
    • clarithromycin (Biaxin)
    • telithromycin (Ketek)
  • certain drugs used to treat viral infections, such as:
    • indinavir (Crixivan)
    • ritonavir (Norvir)
    • saquinavir (Invirase)
  • quinidine, which is used to treat abnormal heart rhythms
  • cinacalcet (Sensipar), which is used to lower calcium levels

Rexulti and drugs that decrease the level of Rexulti in your body

Some drugs can decrease the level of Rexulti in your body. If these drugs are taken with Rexulti, your doctor may increase your dose of Rexulti so that it’s effective for your condition.

Examples of drugs that may decrease your Rexulti level include:

Rexulti and herbs and supplements

It’s possible that Rexulti may interact with certain herbs and supplements. Below, we describe one such interaction. But there may be others as well. Be sure to talk with your doctor about all the herbs and supplements you take before starting Rexulti.

Rexulti and St. John’s wort

The herbal supplement St. John’s wort is sometimes used by people with certain mood disorders, such as depression. However, St. John’s wort interacts with an enzyme (certain protein) in your body that’s used to break down some medications.

Because of this interaction, St. John’s wort may reduce the level of Rexulti in your body. And this could make Rexulti less effective for you.

If you’re taking St. John’s wort, talk with your doctor. They’ll recommend whether you should continue to take this herb. In some cases, your doctor may increase your dose of Rexulti while you’re taking St. John’s wort.

Rexulti and foods

There aren’t any foods that have been specifically reported to interact with Rexulti. If you have any questions about eating certain foods with Rexulti, talk with your doctor.

As with all medications, the cost of Rexulti can vary. To find current prices for Rexulti in your area, check out GoodRx.com.


The cost you find on GoodRx.com is what you may pay without insurance. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Before approving coverage for Injectafer, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered.

If you’re not sure if you’ll need to get prior authorization for Injectafer, contact your insurance company.

Financial and insurance assistance

If you need financial support to pay for Rexulti, or if you need help understanding your insurance coverage, help is available.

Otsuka America Pharmaceutical, Inc., the manufacturer of Rexulti, offers financial support for this medication. If you’d like to know whether your insurance plan may cover Rexulti, visit this program website. And if you’d like to learn about the savings card that’s available for Rexulti, visit this program website.

Generic version

Rexulti is not available in a generic form. (A generic drug is an exact copy of the active drug in a brand-name medication.) Generics tend to cost less than brand-name drugs.

It’s not known if Rexulti is safe to take during pregnancy. This is because there haven’t been any studies done in pregnant women taking the drug.

However, there have been some reports of pregnant women who took a drug that’s similar to Rexulti during their third trimester of pregnancy. The infants who were exposed to the drug during pregnancy had side effects or withdrawal symptoms after they were born.

Examples of side effects and withdrawal symptoms the infants had include:

  • agitation
  • tremors
  • sleepiness
  • trouble breathing
  • trouble feeding
  • problems with muscle movements

If you’re pregnant or thinking of becoming pregnant, talk with your doctor. They can recommend whether it’s safe for you to take Rexulti.

What to do if you take Rexulti during pregnancy

If your doctor recommends that you take Rexulti during pregnancy, there is a pregnancy registry that you’re encouraged to join.

A pregnancy registry collects information about pregnant women who take certain drugs during pregnancy and their infants who were exposed to the drugs. This information can be helpful for doctors and patients considering using these drugs in pregnancy.

You can also sign up for the registry if you think you were exposed to Rexulti while you were pregnant in the past.

For more information and to enroll in Rexulti’s pregnancy registry, visit the registry’s site.

It’s not known if Rexulti is safe to take during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re using Rexulti.

For more information about taking Rexulti during pregnancy, see the section “Rexulti and pregnancy” above.

It’s not known if Rexulti is safe to use while you’re breastfeeding. Animal studies have shown that brexpiprazole (the active drug in Rexulti) can pass into breast milk. But keep in mind that animal studies don’t always predict what will happen in people. In addition, it’s not known how Rexulti would affect a child who’s breastfed.

If you’re breastfeeding or planning to breastfeed, talk with your doctor. They can recommend whether it’s safe for you to take Rexulti.

This drug comes with several precautions.

FDA warnings

This drug has boxed warnings. These are the most serious warnings from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous.

  • Risk of death in certain older adults. Rexulti shouldn’t be used in older people (ages 65 years or older) to treat psychosis that’s related to dementia (memory loss). (With psychosis, you lose touch with reality and hear or see things that aren’t really there.) This is because Rexulti can increase the risk of death in older adults with this condition.
  • Risk of suicidal thoughts and behaviors in certain people. Rexulti, like other drugs used to treat depression, can increase the risk of suicidal thoughts and behaviors in people ages 24 years and younger. If you’re in this age group and you’re using Rexulti, your doctor will monitor you closely. They’ll do this especially at times when you’re starting a new treatment or when your medication dose is adjusted. If you have thoughts of suicide or you attempt to harm yourself, seek medical attention right away. In some cases, your doctor may recommend that you stop using Rexulti. It’s important to note that Rexulti hasn’t been studied for use in children or teenagers. It’s not known if the drug is safe or effective in these people. For this reason, Rexulti shouldn’t be used by people younger than 18 years of age.

Other precautions

Before taking Rexulti, talk with your doctor about your health history. Rexulti may not be right for you if you have certain medical conditions or other factors affecting your health. These include:

  • Allergic reaction. If you’ve had an allergic reaction to Rexulti or any of its ingredients, you shouldn’t take Rexulti. Ask your doctor what other medications are better options for you. And if you’re not sure about your medication allergies, talk with your doctor.
  • Liver damage. If you have a history of liver damage or other liver problems, talk with your doctor before taking Rexulti. Your doctor may adjust your dose of Rexulti to make sure it’s safe for you to take the drug.
  • Poor metabolizer of certain drugs. Because of genetics, some people’s bodies are poor metabolizers of certain drugs. This means the drugs don’t break down like usual, so they may build up and lead to potentially dangerous side effects. Talk with your doctor to find out if your body is a poor metabolizer of certain drugs. If so, your doctor may reduce your dose of Rexulti to help make sure the drug is safe for you to take.
  • Kidney damage. If you have a history of kidney damage or other kidney problems, talk with your doctor before taking Rexulti. Your doctor may adjust your dose of Rexulti to make sure it’s safe for you to take the drug.
  • Hyperlipidemia. If you have hyperlipidemia (high cholesterol or high triglyceride level), Rexulti can further increase your lipid levels. Talk with your doctor about your lipid levels before starting Rexulti.
  • History of compulsive behaviors, such as gambling. Rexulti may increase certain urges such as gambling, sexual desires, binge eating, and compulsive shopping. If you have a history of compulsive behavior or any addictions, talk with your doctor before starting Rexulti.
  • Epilepsy or other seizure disorders. Rexulti can increase your risk of seizures, especially if you have a history of epilepsy or have had seizures before. Make sure you talk with your doctor about any history of seizures before you start treatment with Rexulti.
  • Low blood pressure, high blood pressure, heart disease, or problems with your heart’s electrical pathways. Rexulti may lower your blood pressure when you stand up or sit up, which can cause dizziness or sometimes fainting. If you already have low blood pressure, or a problem with your heart’s electrical pathways, talk with your doctor before taking Rexulti. They can recommend ways to manage your blood pressure while you’re taking Rexulti.
  • Diabetes. Rexulti may increase blood sugar levels in some people. If you have diabetes and you take Rexulti, your blood sugar level may increase to a dangerous level. This can sometimes result in diabetic ketoacidosis (DKA),* diabetic coma, and in rare cases, death. If you have diabetes, talk with your doctor about how to monitor your blood sugar level while you’re taking Rexulti.
  • Pregnancy. It’s not known if Rexulti is safe to take during pregnancy. Some reports have shown that infants exposed to a similar drug during the third trimester of pregnancy have withdrawal symptoms after birth. For more information, please see the section “Rexulti and pregnancy” above.
  • Breastfeeding. It’s not known if Rexulti is safe to use while you’re breastfeeding. For more information, please see the section “Rexulti and breastfeeding” above.

Note: For more information about the potential negative effects of Rexulti, see the section “Rexulti side effects” above.

* DKA is a life threatening condition that’s related to diabetes.

When you get Rexulti from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically 1 year from the date they dispensed the medication.

The expiration date helps guarantee that the medication is effective during this time. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it.

Storage

How long a medication remains good can depend on many factors, including how and where you store the medication.

Rexulti tablets should be stored at room temperature between 68°F and 77°F (20°C and 25°C). They should be kept in a tightly sealed container away from light. Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms. For short periods of time, such as when you’re traveling, Rexulti tablets may be stored between 59°F and 86°F (15°C and 30°C).

Disposal

If you no longer need to take Rexulti and have leftover medication, it’s important to dispose of it safely. This helps prevent others, including children and pets, from taking the drug by accident. It also helps keep the drug from harming the environment.

This article provides several useful tips on medication disposal. You can also ask your pharmacist for information on how to dispose of your medication.

The following information is provided for clinicians and other healthcare professionals.

Indications

Rexulti is indicated as an adjunct treatment for major depressive disorder (MDD) in adults. It is also indicated for use in adults with schizophrenia.

Administration

Rexulti is taken orally as a tablet once per day. It can be administered with or without food.

Mechanism of action

The mechanism of action of Rexulti has not been fully elucidated; however, it is believed to be a partial agonist for serotonin 5-HT1A and dopamine D2 receptors. It is also believed to be an antagonist at serotonin 5-HT2A receptors.

Pharmacokinetics and metabolism

Peak plasma concentrations of Rexulti are achieved 4 hours after a single oral dose, with steady-state achieved after 10 to 12 doses.

Rexulti is highly protein bound to serum albumin in the plasma. It is metabolized by human cytochrome P450, mainly through CYP3A4 and CYP2D6. It is excreted through the urine and feces.

The terminal elimination half-life of brexpiprazole is approximately 91 hours at steady-state, and the terminal elimination half-life of its major metabolite is approximately 86 hours.

Contraindications

Rexulti is contraindicated in people who are allergic to Rexulti or any of the excipients found in the formulation.

Misuse, withdrawal, and dependence

Rexulti is not a controlled substance and has not been shown in studies to foster dependence. Rexulti can however result in withdrawal symptoms if discontinued abruptly.

Storage

Rexulti tablets should be stored at room temperature between 68°F and 77°F (20°C and 25°C). Temporarily, the drug can be stored between 59°F and 86°F (15°C and 30°C).

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.