The Tyrer-Cuzick score measures the likelihood of specific gene mutations relating to breast cancer. A doctor can place people into three categories: average, intermediate, and high risk.
The Tyrer-Cuzick score helps doctors estimate an individual’s level of risk of developing breast cancer, and may help when making recommendations about screening.
While the Tyrer-Cuzick score can be a useful tool, it is not flawless. Results do not automatically indicate if a person will develop breast cancer or not, as there are many individual risk factors involved.
This article will discuss the Tyrer-Cuzick model, how scoring works, and what the results suggest.
The Tyrer-Cuzick model, or international breast cancer intervention study tool, is a calculation to estimate the likelihood that a person will develop breast cancer within the next 10 years. It also estimates their risk over a lifetime.
The test and score can help identify people at higher-than-average risk of breast cancer. Doctors may then recommend additional screening or genetic testing to these individuals.
To calculate a person’s Tyrer-Cuzick score, the model considers their family health history and other potential risk factors.
Some factors that can influence an individual’s Tyrer-Cuzick score include:
- height and weight
- breast density
- history and results of breast biopsies
- personal history of breast or ovarian cancer
- family history of breast or ovarian cancer
- history of hormone use
- Ashkenazi Jewish heritage
- age when the person had their first menstrual period
- age when the person first gave birth, if applicable
- age at menopause, if applicable
- age of cancer diagnosis, if applicable
Based on their Tyrer-Cuzick score, a doctor will put a person’s risk of developing breast cancer into one of three categories:
Doctors generally consider a person with a Tyrer-Cuzick score of less than 15% at average risk of developing breast cancer. A score in this range indicates the person does not necessarily need additional tests outside those generally recommended.
A score of 15–19% indicates an intermediate risk of developing breast cancer. Doctors may recommend additional testing for some people at this risk level, such as those with dense breast tissue. Before proceeding, doctors will explain the issues that can arise from additional testing, such as false positives and other risks of mammogram tests.
Doctors typically consider a score over 20% high risk. They may recommend that people in the high risk group get additional screening tests every year, such as a breast MRI. Doctors may also have further recommendations for each individual, such as supplemental ultrasound testing for those with very dense breast tissue.
A 2016 article suggests the Tyrer-Cuzick model is the most comprehensive and sensitive model for detecting breast cancer risk, and the only model that accounts for both personal and extensive familial risk factors.
However, people should be aware that two of the authors of this study receive royalty payments for commercial use of the Tyrer-Cuzick model through Cancer Research UK.
The authors of a
An assessment of cancer risk is only a general estimate. People in average risk groups may still get breast cancer, and those in high risk groups may never develop the illness.
While the Tyrer-Cuzick model can be helpful, it may fail to take certain factors into account. For example, risk level varies by race and ethnicity, but a
Another 2018 article states that while the Tyrer-Cuzick model seems to be the most consistently accurate tool for predicting breast cancer risk, its use of breast density as a risk factor is not validated. Researchers are currently studying the determinants of breast cancer risk further, and their results will help improve the test.
For all these reasons, doctors will not rely on a Tyrer-Cuzick score as their only screening tool.
Online assessment tests may help an individual gauge their risk of developing breast cancer. However, they are not diagnostic tools. Anyone who would like to understand their risk for breast cancer should speak with a doctor about a full screening.
Healthcare professionals generally recommend people begin having annual mammograms around age
A doctor may recommend several other tools to help assess a person’s risk of breast cancer moving forward. As well as mammograms, a personalized screening plan may
- genetic testing
- imaging tests such as MRI and ultrasound
- monthly self-exams
- tests for breast density
Doctors may also recommend preventative measures, such as adjusting lifestyle factors where applicable. This may
A Tyrer-Cuzick score can give a general indication of a person’s risk of developing breast cancer over the next 10 years and throughout their lifetime. These scores are not definitive but provide guidelines for doctors to help make decisions about screening and additional testing in each case.
Doctors may recommend that a person with a high Tyrer-Cuzick score undergo additional annual screening, including MRI and ultrasound tests. Doctors will discuss the risks and benefits of any test with each person before making a recommendation.