Refractory celiac disease is a type of celiac disease that is unresponsive to at least 12 months of a strict gluten-free diet.
Celiac disease is a common gastrointestinal disorder that most people manage with a gluten-free diet. However, people with refractory celiac disease who omit gluten do not see an improvement in their symptoms and continue to have the hallmark signs of damage to the gut.
This article explores refractory celiac disease and its symptoms and causes. Next, it explains how a doctor diagnoses the condition, potential complications, and treatments. Finally, it answers some frequently asked questions.
Celiac disease is a chronic autoimmune condition. When genetically predisposed people react to gluten, the body mounts an immune response, causing damage to cells in the gut and sometimes elsewhere in the body.
According to a
- intestinal, or classic
- extraintestinal, or nonclassic
- gluten-free diet nonresponsive
The review explains that refractory celiac disease causes persistent symptoms and damage to the cells lining the gut after at least 12 months of a strict gluten-free diet.
Additionally, it notes two subtypes of refractory celiac disease, type 1 and 2, whose genetics vary slightly. Type 2 predominantly occurs in adults aged
The 2019 review states the symptoms of refractory celiac disease in adults are:
Experts associate these symptoms with persistent villous atrophy — damage to the gut cells — after at least 1 year on a strict gluten-free diet.
Additionally, people may get symptoms of complications,
The exact causes of refractory celiac disease remain unclear. However, experts suggest the following elements of the body’s immune system are involved:
Lymphocytes are white blood cells and one of the body’s main types of immune cells. T lymphocytes (T cells) are one of the two main categories of lymphocytes.
Intraepithelial lymphocytes are T cells in the intestinal lining. Doctors refer to the protein on the surface of T cells as the T cell receptor (TCR).
In celiac disease, when the TCR recognizes gluten, the protein activates. With a gluten-free diet, these T cells become inactive, and the intestinal damage heals. However, in the case of refractory celiac disease, intestinal T cells activate without gluten, and intestinal damage persists despite removing gluten from the diet.
Cytokines are small proteins that help regulate communication among the cells of the immune system and other tissues.
Research suggests that people with refractory celiac disease have an increased number of proinflammatory cytokines called interleukin-15 (IL-15). These proteins support inflammation.
IL-15 stimulates another small protein known as interferon-gamma, which increases the toxicity of the T cells in the intestinal lining. As damage occurs to more and more cells in the lining of the intestine, symptoms of refractory celiac disease develop.
Celiac disease causes
People with celiac disease usually have variants of the genes DQ2 and DQ8. People who do not have these gene variants are very unlikely to develop celiac disease.
However, according to the NIDDK, even though around 30% of people have DQ2 or DQ8, only about 3% of these develop celiac disease. Researchers are studying the reasons for this and other genes that may be involved.
While experts estimate that about
According to the 2019 review, doctors have traditionally referred to persistent symptoms on a strict gluten-free diet as nonresponsive celiac disease cases.
However, the review notes that this terminology is confusing as the patient may have symptoms due to other associated conditions, such as small intestinal bacterial overgrowth or inflammatory bowel disease (IBD). Therefore, the authors suggest doctors differentiate ongoing active celiac disease and other gastrointestinal conditions.
The review states that refractory celiac disease represents about 10% of all ongoing active celiac disease cases.
Assessment and tests
Doctors diagnose the condition by assessing the symptoms and gut damage for at least a year after beginning a strict gluten-free diet. They confirm a diagnosis with a celiac disease antibody test and by checking for villous atrophy — damage to the cells lining the intestine. They may perform a biopsy to establish this.
Additionally, the review explains that doctors may diagnose either primary or secondary refractory celiac disease depending on whether a person’s symptoms have improved since the beginning of a gluten-free diet.
Furthermore, doctors must define whether a person has subtype 1 or 2, as this affects their outlook.
A doctor may perform various diagnostic tests, including:
The 2019 research review indicates that refractory celiac disease can lead to the following complications:
- Ulcerative jejunoileitis: This condition causes ulcers and scarring in parts of the intestines that doctors refer to as the jejunum and ileum.
- Collagenous sprue: This condition affects the mucosa in the small bowel, creating collagen deposits.
- Intestinal lymphoma: This is a type of stomach cancer.
The subtype of refractory celiac disease that someone has affects their long-term outlook.
The review suggests that subtype 2 has a 5-year mortality rate of 55% compared with 7% for subtype 1. The higher mortality rate for type 2 is mainly due to more people with this form developing intestinal lymphoma.
Currently, the only treatment for celiac disease is a lifelong, strictly gluten-free diet.
Doctors treat refractory celiac disease according to the subtype.
It is necessary for a person to speak to their doctor to obtain a diagnosis and treatment if they have symptoms of either type.
The following section answers some commonly asked questions about this condition.
What is the life expectancy for someone with refractory celiac disease?
Is refractory celiac disease the same as nonresponsive celiac disease?
The 2020 review indicates that nonresponsive celiac disease may occur due to refractory celiac disease. Still, it can also result from other causes, such as not adhering to a gluten-free diet or having another associated condition, such as irritable bowel syndrome (IBS) or IBD.
Refractory celiac disease is a type of celiac disease characterized by ongoing gut damage and symptoms even with a strict gluten-free diet. However, assessing someone’s gluten ingestion is challenging, and nonadherence may appear as refractory celiac disease. A doctor will also need to rule out other associated conditions, such as IBS or IBD, before making a diagnosis.
Doctors diagnose refractory celiac disease using symptoms, imaging tests, and biological samples. Refractory celiac disease may cause complications, and the outlook for a person with the condition depends on the subtype they have.