Computational protein design aims at the engineering of proteins with targeted functions by using modelling and high-throughput computing.

We will discuss the main challenges faced by this approach before it will become a standardised technique in synthetic biology.

We also describe its integration with experimental techniques such as directed evolution. We finalise by presenting future perspectives in the field

Journal of the Royal Society Interface

Journal of the Royal Society Interface is the Society's cross-disciplinary publication promoting research at the interface between the physical and life sciences. It offers rapidity, visibility and high-quality peer review and is ranked fifth in JCR's multidisciplinary category. The journal also incorporates Interface Focus, a peer-reviewed, themed supplement, each issue of which concentrates on a specific cross-disciplinary subject.

Journal of the Royal Society Interface