Primary sclerosing cholangitis, also known as PSC, is a liver disease with no effective medical treatment. Liver transplantation is the only proven long-term treatment of PSC, although only a fraction of individuals with PSC will ultimately require it. The vast majority of patients with PSC also have inflammatory bowel disease (Crohn's disease or ulcerative colitis), possibly implying that the intestine plays a role in the origin of this PSC. Researchers from VIB, UZ Leuven and KU Leuven now describe for the first time how changes in the intestinal microbiota are specifically associated with this disease.
These novel insights are the result of a long-standing collaboration between the research groups of prof. Jeroen Raes (VIB/KU Leuven) and prof. Severine Vermeire (KU Leuven/UZ Leuven). Combining their expertise in metagenomics of the gut flora (Jeroen Raes lab) and clinical expertise in gastroenterology (Severine Vermeire lab), they make a successful alliance for unravelling the role of gut flora in the development of gastro-intestinal diseases. The first results of this collaboration are now published in the leading scientific journal Gut.
Prof. Jeroen Raes (VIB/KU Leuven): "Using massive DNA sequencing, we compared the gut bacteria in patients with PSC and in healthy people. Based on the differences found, we could develop a signature to diagnose PSC based on gut bacteria. Although very promising, our findings now need to be confirmed before they can be used in clinical practice."
The findings may not only lead to a novel diagnosis tool of PSC, they may also be the starting point for developing microbiota-based therapies. But there is still a long way to go. Prof. Severine Vermeire (KU Leuven/UZ Leuven): "In the future, gut bacteria may be used to help identify PSC patients with a more or less aggressive disease, or patients that may benefit from microbiota-based therapies, such as fecal microbiota transplantation or targeted pre- and probiotics."
Both teams are planning to further investigate the complex interactions between the immune system and the intestinal microbiota in PSC patients.
Article: Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD, João Sabino, Sara Vieira-Silva, Kathleen Machiels, Marie Joossens, Gwen Falony, Vera Ballet, Marc Ferrante, Gert Van Assche,Schalk Van der Merwe, Severine Vermeire, Jeroen Raes, Gut, doi:10.1136/gutjnl-2015-311004, published onlien 20 May 2016.