Doctors, pilots, air traffic controllers and bus drivers have at least one thing in common - if they're exhausted at work, they could be putting lives at risk. But the development of a new urine test, reported in the ACS journal Analytical Chemistry, could help monitor just how weary they are. The results could potentially reduce fatigue-related mistakes by allowing workers to recognize when they should take a break.
The effects of fatigue have long been recognized and studied as a problem in the transportation and healthcare industries. In the early 2000s, studies published in scientific journals reported that fatigue-related mistakes were linked to thousands of vehicular crashes every year, and were a major concern in patient safety. Weariness can cause anyone on or off the job to lose motivation and focus, and become drowsy. Although very common, these symptoms come with biochemical changes that are not well understood. Zhenling Chen, Xianfa Xu and colleagues set out to determine whether a urine test could detect these changes.
The researchers analyzed urine samples from dozens of air traffic controllers working in civil aviation before and after an 8-hour shift on the job. Out of the thousands of metabolites detected, the study identified three that could serve as indicators of fatigue. Further work is needed to validate what they found, the researchers say, but their initial results represent a new way to investigate and monitor fatigue - and help prevent worn-out workers from making potentially dangerous errors.
The authors acknowledge funding from the National Natural Science Foundation of China and the Civil Aviation Administration of China.
Article: Application of LC-MS-Based Global Metabolomic Profiling Methods to Human Mental Fatigue, Zhenling Chen, Xianfa Xu et al., Analytical Chemistry, doi: 10.1021/acs.analchem.6b03421, published 10 November 2016.