In 1995, President Ronald Reagan and First Lady Nancy Reagan joined forces with the Alzheimer?s Association to create the Ronald and Nancy Reagan Research Institute, a forward-looking initiative dedicated to accelerating progress in Alzheimer research.

The Alzheimer?s Association Reagan Research Institute is a portfolio of funded projects within our grants program that serves as a paradigm for one key principle of our entire research effort?a commitment to innovative basic science exploring the broadest possible spectrum of approaches to developing Alzheimer treatments.

The scope and creativity of the Alzheimer?s Association Reagan Research Institute research reflects a conviction strongly held by most experts?that successful treatments for Alzheimer?s, as for other complex diseases, will likely involve an array of strategies rather than a single ?magic bullet.?

Establishing the Alzheimer?s Association Reagan Research Institute marked an important developmental milestone in the maturation of our research program. When the Association first began awarding grants in 1982, most awards funded descriptive projects posing broad questions about the nature of Alzheimer?s and its effects.

Creation of the Reagan Institute, with its focus on cutting-edge, basic science, helped direct evolution of the biological segment of our program toward funding innovative explorations aimed at precise molecular targets.

Projects in the Institute are selected by senior science staff to highlight creative approaches to core areas of inquiry, including processing and pathology of amyloid and tau; other key cellular processes and pathways; genetics; animal models; inflammation and oxidative stress; and synergistic effects of vascular factors.

Selected projects also represent some degree of geographical balance and support scientists at every stage of their professional lives, including early-career investigators who earned their doctoral degrees less than 10 years ago.

In addition to funding individual projects, the Institute supports the activities of the Association?s Work Groups. These teams of thought leaders in Alzheimer research and care, led by members of the Association?s Medical and Scientific Advisory Council, provide authoritative guidance on issues in research, caregiving, public policy, and programs and services.