Common Causes Of Schizophrenia And Bipolar Disorder
Schizophrenia and bipolar disorder (also known as manic-depressive illness) are the two most common psychotic disorders. For over a century, the two diseases have been treated as distinct by clinical practitioners and researchers as regards definitions and risk factors. However, such strict classification has met increasing scepticism over the years, partly owing to the results of modern genetic science, which has shown that certain genes seem to affect both disorders.
To study whether schizophrenia and bipolar disorder have the same genetic causes, Swedish scientists analysed the records of two million families, including 35,985 patients with schizophrenia, 40,487 patients with bipolar disorder, and the blood relatives of both.
Their results show that members of families in which someone has either schizophrenia or bipolar disorder run an increased risk of developing the same condition. The results also show that this is chiefly the result of genetic factors, and only slightly due to shared environmental factors. The scientists also found that patients with schizophrenia are also more prone to bipolar disorder, and that relatives of patients with one of the diseases are more likely to have relatives with the other.
According to the researchers, the results, taken as a whole, provide convincing proof that schizophrenia and bipolar disorder are very much hereditary diseases, and that they share, in part, a common genetic cause. They also argue that it is important for clinicians and researchers to take this common genetic background into account when studying and treating schizophrenia and bipolar disorder.
The study was funded by the Swedish Council for Working Life and Social Research and the Swedish Research Council.
"Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study"
Paul Lichtenstein, Benjamin H Yip, Camilla Björk, Yudi Pawitan, Tyrone D Cannon, Patrick F Sullivan, Christina M Hultman
The Lancet, 16 January 2009
Download images: http://ki.se/pressimages
Karolinska Institutet is one of the leading medical universities in Europe. Through research, education and information, Karolinska Institutet contributes to improving human health. Each year, the Nobel Assembly at Karolinska Institutet awards the Nobel Prize in Physiology or Medicine.
There are no references listed for this article.
Please use one of the following formats to cite this article in your essay, paper or report:
Institutet, Karolinska. "Common Causes Of Schizophrenia And Bipolar Disorder." Medical News Today. MediLexicon, Intl., 18 Jan. 2009. Web.
23 Jun. 2017. <http://www.medicalnewstoday.com/releases/135731.php>
Institutet, K. (2009, January 18). "Common Causes Of Schizophrenia And Bipolar Disorder." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
Contact our news editors
For any corrections of factual information, or to contact our editorial team, please see our contact page.
Copyright Medical News Today: Excluding email/sharing services explicitly offered on this website, material published on Medical News Today may not be reproduced, or distributed without the prior written permission of Medilexicon International Ltd. Please contact us for further details.