Among the treatments for obstructive sleep apnea, the effectiveness of a nighttime-breathing machine called a "CPAP" was backed by the strongest evidence, and a mouthpiece worn at night was also shown to be effective, according to a new report funded by HHS' Agency for Healthcare Research and Quality.

Sleep apnea is a disorder that disrupts sleep for an estimated 12 million Americans, with millions more likely undiagnosed. The report found that the continuous positive airway pressure (CPAP) machine, which pumps air through a mask while the patient is asleep, is highly effective in improving sleep and related symptoms of obstructive sleep apnea by improving airflow. Another treatment, a mouthpiece called a mandibular advancement device (MAD), can also be very effective, the report found.

Weight loss and surgery may also be effective, although the evidence behind these treatments is not as strong, according to the report, a comparative effectiveness review prepared by the Tufts Medical Center Evidence-based Practice Center for AHRQ's Effective Health Care Program. The report does note that all treatments have possible side effects.

To highlight the findings of the report, AHRQ also published guides for consumers and clinicians that summarize the latest evidence for treating obstructive sleep apnea, a disorder that can lead to heart disease, diabetes and multiple other health problems.

Source: Agency for Healthcare Research and Quality (AHRQ)