Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
Nasopharyngeal carcinoma (NPC) affects cells lining the nasopharynx. The majority of NPC cases can be cured by radiation therapy, however ~20% are resistant to radiation treatment.
In this issue of the Journal of Clinical Investigation, Yu-Sun Chang and colleagues at Chang Gung University sought to find a way to predict which individual cases of NPC would be sensitive to radiation therapy.
The authors compared the levels of various serum factors between NPC patients that responded to radiation therapy and patients that were resistant to therapy.
Patients that did not respond to radiation therapy had higher serum levels of the IL-6 family cytokine leukemia inhibitory factor (LIF), and that LIF levels were predictive of NPC patient response to radiation therapy.
The researchers further demonstrated that LIF itself promotes NPC.
In the companion commentary, Micah Luftig from the Duke University School of Medicine discusses the implications of LIF as a predictor of NPC resistance to radiation therapy.
ACCOMPANYING COMMENTARY TITLE: Heavy LIFting: tumor promotion and radioresistance in NPC
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Ear, Nose and Throat category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Journal of Clinical Investigation. "Nasopharyngeal carcinoma patient response to radiation therapy predicted." Medical News Today. MediLexicon, Intl., 27 Nov. 2013. Web.
9 Mar. 2014. <http://www.medicalnewstoday.com/releases/269328>
Journal of Clinical Investigation. (2013, November 27). "Nasopharyngeal carcinoma patient response to radiation therapy predicted." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/269328.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.