Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
A study has shown that a daily probiotic drink changed how cells lining the nasal passages of hay fever sufferers reacted to a single out-of-season challenge. However, it did not lead to significant changes in hay fever symptoms, although this challenge test may not have accurately represented natural allergen exposure.
Our immune system must distinguish between "friends" that can be beneficial to our health and "foes" that can have harmful effects. There is now a growing body of evidence that the gut microbiota, the trillions of bacteria that live in our gut, influences that recognition. When it fails an immune response occurs. This is the case with hay fever, or seasonal allergic rhinitis, when the immune system reacts to pollen or fungal spores.
Previously, a research team at the Institute of Food Research (IFR) found that taking a drink containing the probiotic bacterium Lactobacillus casei changed how our immune system responds to grass pollen, measured through changes in molecules produced by the immune system.
A new study, published in the journal PLOS ONE, shows for the first time how these probiotics can interact with cells in our gut to produce systematic changes in cells lining our nasal cavity.
Funded by Yakult and the Biotechnology and Biological Sciences Research Council (BBSRC), clinicians and scientists at IFR and the University of East Anglia (UEA) on the Norwich Research Park gave 60 hay fever sufferers daily drinks for 16 weeks, outside of the hay fever season. One group was given a drink containing Lactobacillus casei Shirota, and the other group received very similar drinks without the probiotic. The study was double-blinded and placebo controlled, so neither the volunteers nor the scientists knew which group was receiving the probiotic. Samples were taken from the volunteers' nasal cavities and blood, both before and after being challenged with pollen to trigger their allergy. This was then repeated at the end of the 16-week intervention. Clinical measurements of the symptoms of hay fever were also recorded.
Volunteers who received the probiotic drink saw changes in allergic inflammation in their nasal lining, as well as changes in their blood, that are associated with immune responses. This is strong evidence of how the gut microbiota can influence cells of the gut lining, and have a systematic influence on our bodies and distant cells, such as those lining our nasal passages. But despite this, the probiotic had no detectable effect on the symptoms of hay fever.
Hay fever is a complicated condition to assess, and mimic in a clinical setting. The researchers used a single allergy challenge, applied to the volunteers' nasal passage, to provide a standard, reproducible test to help ensure all the subsequent results are comparable. In the real world hay fever is usually triggered by longer term exposure to the allergen, variable in strength and timing over a period of days or weeks. The IFR researchers are now exploring the possibility of carrying out a seasonal study to investigate whether the changes in the nasal mucosa seen in this single challenge study relate to changes in hay fever symptoms triggered by a more realistic natural exposure to pollen.
Oral Delivery of a Probiotic Induced Changes at the Nasal Mucosa of Seasonal Allergic Rhinitis Subjects after Local Allergen Challenge: A Randomised Clinical Trial, PLOS ONE DOI: 10.1371/journal.pone.0078650
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Allergy category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
Institutes, Norwich BioScience. "How probiotics could affect hay fever." Medical News Today. MediLexicon, Intl., 30 Nov. 2013. Web.
11 Mar. 2014. <http://www.medicalnewstoday.com/releases/269437>
Institutes, N. (2013, November 30). "How probiotics could affect hay fever." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/269437.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT (logo) is the registered trade mark of MediLexicon International Limited.