Creating a free account will enable you to subscribe to our daily and weekly email newsletters, as well as customize your reading experience to show only the categories most relevant to you.
Signing up only take a few minutes, so why not give it a try and see what you've been missing out on.
New imaging research from Western University (London, Canada) has demonstrated that a magnetic resonance imaging (MRI) approach called quantitative susceptibility mapping (QSM) can be an important tool for diagnosing and tracking the progression of Multiple Sclerosis (MS) and other neurological diseases. QSM provides a quantitative way to measure myelin content and iron deposition in the brain -important factors in the physiology of MS. The research led by Ravi Menon, PhD, a scientist at Western's Robarts Research Institute, is published in this week's Proceedings of the National Academy of Sciences (PNAS).
Menon and his associates including first author David Rudko, set out to determine whether QSM was indeed quantitative. Interpretation of QSM data requires the use of a model of the underlying tissue structure. The scientists found that the most common approach to creating QSM images was in fact insufficient to generate quantitative images - that is images in which myelin content and iron can be measured. They demonstrated this by exploring the orientation dependence of the MRI signal. This particular signal has generally thought to be a constant, but the team showed that it depends on tissue orientation in both cortical grey and white matter, but not in the deep brain structures such as the basal ganglia. All these areas are implicated in MS.
They demonstrated the discordance between the models for QSM using a device that rotated a rat's brain so that it could be scanned from 18 different angles, using a 9.4 T MRI. The brains were then sent to histology for comparison. They found the values depended on the microstructure of the brain such as myelin concentration and integrity, and iron deposition. The study also showed, for the first time, the correlation between MRI measurement and histology measurement when the correct model was used.
"With this methodology, we now have a quantitative way to interpret myelin and iron concentrations, and in particular, any changes to them over time," says Menon, who holds a Canada Research Chair in Functional Magnetic Resonance Imaging. "We've been doing these scans on MS patients for a while, but nobody knew if it was a valid approach or not. We now know how to interpret the data. It allows us to separate changes in white matter degeneration, from other changes such as iron deposition, which in conventional imaging all looks the same."
Menon says the next step is to use this new imaging approach to study the changes that occur in MS and to find out if it is predictive of disease progression.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our Multiple Sclerosis category page for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:
University of Western Ontario. "MRI method for measuring MS progression validated." Medical News Today. MediLexicon, Intl., 31 Dec. 2013. Web.
25 Apr. 2014. <http://www.medicalnewstoday.com/releases/270532>
University of Western Ontario. (2013, December 31). "MRI method for measuring MS progression validated." Medical News Today. Retrieved from
Please note: If no author information is provided, the source is cited instead.
If you write about specific medications, operations, or procedures please do not name healthcare professionals by name.
For any corrections of factual information, or to contact our editorial team, please use our feedback form. Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
This page was printed from: http://www.medicalnewstoday.com/releases/270532.php
Visit www.medicalnewstoday.com for medical news and health news headlines posted throughout the day, every day.
© 2004-2014 All rights reserved. MNT is the registered trade mark of MediLexicon International Limited.