Yo-yo dieting may trick the brain into thinking it is in the midst of famine, prompting the body to store fat and, ultimately, gain weight.
The study, published in the journal Evolution, Medicine and Public Health, was led by Prof. Andrew Higginson, from the University of Exeter, and Prof. John McNamara, of the University of Bristol, both in the United Kingdom.
Keeping weight in check is a health benefit; compared with people of a healthy weight, people who are obese are at increased risk for many diseases.
More than one-third of adults in the United States are obese, so keeping weight at a healthy level is a major priority from a public health perspective.
Although shedding holiday pounds may be a popular focus for many of us in January, the Centers for Disease Control and Prevention (CDC), say that people who lose weight gradually - about 1-2 pounds per week - are more successful at keeping the weight off.
'Weight gain for dieters greater than for non-dieters'
Previous studies have investigated the negative health effects of yo-yo dieting. One study recently presented by the American Heart Association suggested that yo-yo dieting increases the risk of heart disease death.
For the latest study on yo-yo dieting, the researchers utilized a mathematical model of animals - such as birds - that knows when food is in abundance or is scarce but does not know when the situation will change.
The researchers note that animals respond to food shortages by storing energy and gaining weight.
Their model demonstrates that when food is in short supply - much like during a phase of dieting - an efficient animal will gain excess weight between periods of food shortage.
"Surprisingly," says Prof. Higginson, "our model predicts that the average weight gain for dieters will actually be greater than those who never diet. This happens because non-dieters learn that the food supply is reliable so there is less need for the insurance of fat stores."
Prof. McNamara adds that their model "shows that weight gain does not mean people's physiology is malfunctioning or that they are being overwhelmed by unnaturally sweet tastes."
It could be that their brain is working normally, "but uncertainty about the food supply triggers the evolved response to gain weight," he adds.
'Best thing for weight loss is to take it steady'
The researchers say their model shows that the desire to eat increases as a diet continues, and this desire will not go away as weight is gained. This is because the brain thinks that further famines are likely.
The model may explain why many people get into a cycle of weight gain in the wake of increasingly restrictive diets; it only serves to communicate to the brain that it must store fat.
For those of us who over-indulge during the holiday season, however, what is the best way to lose weight?
"The best thing for weight loss is to take it steady. Our work suggests that eating only slightly less than you should, all the time, and doing physical exercise is much more likely to help you reach a healthy weight than going on low-calorie diets."
Prof. Andrew Higginson, University of Exeter
Once a healthy weight is achieved, the CDC say to rely on healthful eating and physical activity most days of the week to keep the weight off over the long term.