The Epstein-Barr virus does not cause leukemia, but scientists are investigating whether it plays a part in how the disease progresses.
In this article, we look at the evidence of a possible link between Epstein-Barr infection and CLL.
The causes of CLL are still unclear, and a potential link with the EBV is just one avenue of research.
One study from 2015 found strong evidence of an association between the infection and the disease. The research team tested 220 people with newly diagnosed CLL and found that
The researchers also found that the participants with higher quantities of EBV DNA had poorer outcomes and shorter overall survival rates.
However, they were quick to note that further research is needed to establish whether the virus is responsible for accelerating CLL progression — or if the infection is just a sign that the person’s immune system is already weakened due to the cancer.
Other studies seem to support the idea that high levels of EBV DNA can be used to predict the outcome of CLL.
They found that people with higher levels of EBV DNA needed medical treatment sooner than those with lower levels. Like the other team, they saw shorter overall survival rates among people with CLL and high levels of the viral DNA.
A further study by the same scientists in 2019 determined that the worse outcomes for people with CLL and the EBV could partially stem from a higher prevalence of specific proteins that increase the growth of the cancer.
High levels of these proteins interfere with the normal cell cycle, preventing cell death. The team found a positive correlation between high levels of these proteins and a high EBV DNA load.
This is known as Richter syndrome, and it occurs in
At the moment, there is no conclusive evidence, and research is ongoing.
A separate 2019 study suggests a possible link between EBV and the development of CLL. The researchers conclude that EBV plays a part in transforming B cells, also known as B lymphocytes.
B lymphocytes are a part of the immune system, and they make antibodies. They develop in bone marrow, and researchers have linked disturbances in the development of these cells with leukemia and other diseases.
Each study that investigates a possible link between the virus and CLL highlights the importance of further research, particularly into how EBV behaves in healthy people, as past efforts have limited their scope to the effects in people with specific diseases.
This virus is extremely common, and
Once a person contracts the infection, the virus stays in their body for life. For the
Sometimes, however, the virus reactivates, and people with weakened immune systems may experience symptoms of the infection.
Every year, EBV is associated with 200,000 cases of cancer worldwide. As yet, however, there is no way of knowing who will develop these cases.
Currently, health experts know that EBV
Cancers associated with EBV include:
- Hodgkin lymphoma
- Burkitt lymphoma
- diffuse large B cell lymphoma
- nasopharyngeal cancers
Research into the link between EBV and cancer, published in 2015, reports that scientists have written
So far, evidence suggests that high levels of the EBV may predict the speed at which the disease progresses. Findings such as this may help doctors identify people who are likely to need treatment sooner than others with CLL.